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| There are 493 papers published in subject: since this site started. | |||
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| 1. A review: Inhibitors and activators for paraoxonase 1 | |||
| Li Yan,Tang Meiling,Chen Gang,Mu Xiaojing,Huang Haiming | |||
Biology 23 April 2020
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| Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
| Abstract:Paraoxonase 1 (PON1) is a calcium-dependent hydrolase with many physiological functions. The decrease of PON1 activity is related to many diseases. The research about PON1 is a hot topic, and its activators and inhibitors are expected to help in our diets and in choose of drugs. The papers about PON1 activators and inhibitors were collected and classified. The PON1 activators and inhibitors are grouped into four categories: in-vivo activators, in-vitro activators, in-vivo inhibitors and in-vitro inhibitors. For each activator or inhibitor, the activating effect or inhibiting effect along with the methods used was reviewed. Up to now, we found from literatures that there were 16 samples demonstrating activating effects on PON1 in-vivo and 5 compounds showed in-vitro activation. Of the 16 in-vivo activators there were 4 plant extracts and 12 pure components. Seven in-vivo inhibitors and 71 in-vitro inhibitors have been reported in publications. Additionally, smoking, drinking and treatment with exogenous gonadotropins induced decrease of PON1 activity. The summary of the activators and inhibitors are beneficial to reveal the structure-activity relationship, and also it provides convenience to look up the activating or inhibiting effects of the compounds on PON1 at a glance. | |||
| TO cite this article:Li Yan,Tang Meiling,Chen Gang, et al. A review: Inhibitors and activators for paraoxonase 1[OL].[23 April 2020] http://en.paper.edu.cn/en_releasepaper/content/4751765 | |||
| 2. A 69 nt segment in the 5'UTR regulates translation of FOXO3a under stress conditions | |||
| Zhang Xuyan,Zhou Kantian,Zhu Ruiyu | |||
Biology 31 March 2020
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| Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
| Abstract:Fork head box O3 (FOXO3a) is a transcription factor that mediates various fundamental cellular processes, including cell cycle progression, proliferation, DNA damage and apoptosis. This study showed that the 5\' untranslated region (5\'UTR) of FOXO3a mRNA contains an internal ribosome entry site (IRES). After mapping the 5\'UTR of FOXO3a mRNA, we found that a 69 nt sequence located between 175-243 was the key segment for the overall IRES activity. Further, we generated a knockout cell line of this 69 nt segment using CRISPR technology. During serum-starvation and ADM drug stress, the deletion of this 69 nt segment could inhibit the expression of FOXO3a to some extent in the knockout cells. These results strongly suggested that the 69 nt segment is essential for self-regulation of FOXO3a under stress conditions, and could be a potential target for the regulation of FOXO3a. | |||
| TO cite this article:Zhang Xuyan,Zhou Kantian,Zhu Ruiyu. A 69 nt segment in the 5'UTR regulates translation of FOXO3a under stress conditions[OL].[31 March 2020] http://en.paper.edu.cn/en_releasepaper/content/4751435 | |||
| 3. TH upstream-inhibited UBR5 subnetwork for learning in human left hemisphere|Prostate via nucleus to cytoplasm protein binding | |||
| Wang Yuanzhen,WANG Lin,HUANG Juxiang | |||
| Biology 27 December 2019 | |||
| Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
| Abstract:High tyrosine hydroxylase (TH) upstream-inhibited ubiquitin protein ligase E3 component n-recognin 5 (UBR5) molecular subnetwork was constructed, including feedback sulfotransferase family 1A member 2 (SULT1A2); downstream chromosome 10 open reading frame 10 (C10orf10), heterogeneous nuclear ribonucleoprotein H3 (HNRPH3), UPF3 regulator of nonsense transcripts homolog A (yeast) (UPF3A) reported relation with learning in human left hemisphere. The common biology process of TH upstream-inhibited UBR5 subnetwork was identified by DAVID, containing feedback SULT1A2, downstream HNRPH3, downstream UPF3A, second-core UBR5, first-core TH as protein binding; downstream HNRPH3, downstream UPF3A, second-core UBR5 as RNA binding; feedback SULT1A2, first-core TH as small molecule metabolic process; downstream HNRPH3, downstream UPF3A as nucleotide binding; The common cellular component of downstream HNRPH3, downstream UPF3A, second-core UBR5, first-core TH as nucleus; feedback SULT1A2, downstream UPF3A, first-core TH as cytosol; downstream HNRPH3, downstream UPF3A, second-core UBR5 as nucleoplasm; downstream UPF3A, second-core UBR5, first-core TH as cytoplasm; downstream C10orf10, first-core TH as mitochondrion; The common tissue distributions as Prostate_3rd maybe exist the same pattern with human left hemisphere. We propose and mutual positively verify tyrosine hydroxylase (TH) upstream-inhibited ubiquitin protein ligase E3 component n-recognin 5 (UBR5) subnetwork for learning in human left hemisphere|Prostate via nucleus to cytoplasm protein binding. | |||
| TO cite this article:Wang Yuanzhen,WANG Lin,HUANG Juxiang. TH upstream-inhibited UBR5 subnetwork for learning in human left hemisphere|Prostate via nucleus to cytoplasm protein binding[OL].[27 December 2019] http://en.paper.edu.cn/en_releasepaper/content/4750367 | |||
| 4. TH upstream-inhibited DCI subnetwork for learning in human left hemisphere|Tonsil via nucleo to cytoplasm poly(A) RNA binding | |||
| YANG Kaitong,WANG Lin,HUANG Juxiang | |||
| Biology 24 December 2019
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| Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
| Abstract:High tyrosine hydroxylase (TH) upstream-inhibited enoyl-CoA delta isomerase 1 (DCI) molecular subnetwork was constructed, including upstream NCK adaptor protein 2 (NCK2), retinoblastoma binding protein 6 (RBBP6), sulfotransferase family 1A member 2 (SULT1A2); downstream chromosome 10 open reading frame 10 (C10orf10), forkhead box N3 (FOXN3_2), poly (rC) binding protein 2 (PCBP2_2) reported relation with learning in human left hemisphere. The common biology process of TH upstream-inhibited DCI subnetwork was identified by DAVID, containing upstream NCK2, upstream RBBP6, upstream SULT1A2, downstream FOXN3_2, downstream PCBP2_2, first-core TH as protein binding; upstream SULT1A2, second-core DCI, first-core TH as small molecule metabolic process; upstream RBBP6, downstream PCBP2_2 as poly(A) RNA binding; downstream PCBP2_2, first-core TH as enzyme binding; The common cellular component of upstream NCK2, upstream RBBP6, downstream PCBP2_2, first-core TH as cytoplasm; upstream NCK2, upstream SULT1A2, downstream PCBP2_2, first-core TH as cytosol; downstream C10orf10, second-core DCI, first-core TH as mitochondrion; downstream FOXN3_2, downstream PCBP2_2, first-core TH as nucleus; upstream RBBP6, downstream PCBP2_2 as nucleoplasm; downstream PCBP2_2, second-core DCI as extracellular exosome; The common tissue distributions as Tonsil_3rd maybe exist the same pattern with human left hemisphere. We propose and mutual positively verify tyrosine hydroxylase (TH) upstream-inhibited enoyl-CoA delta isomerase 1 (DCI) subnetwork for learning in human left hemisphere|Tonsil via nucleo to cytoplasm poly(A) RNA binding. | |||
| TO cite this article:YANG Kaitong,WANG Lin,HUANG Juxiang. TH upstream-inhibited DCI subnetwork for learning in human left hemisphere|Tonsil via nucleo to cytoplasm poly(A) RNA binding[OL].[24 December 2019] http://en.paper.edu.cn/en_releasepaper/content/4750327 | |||
| 5. TH upstream-inhibited CYFIP2 subnetwork for learning via cytoplasm to nucleus small GTPase mediated signal transduction | |||
| ZHANG Weijian,HUANG Juxiang,WANG Lin | |||
Biology 23 December 2019
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| Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
| Abstract:High tyrosine hydroxylase (TH) upstream-inhibited cytoplasmic FMR1 interacting protein 2 (CYFIP2) molecular subnetwork was constructed, including feedback SMAD family member 1 (SMAD1_2); downstream Rho GTPase activating protein 12 (ARHGAP12), forkhead box N3 (FOXN3_2) reported relation with learning in human left hemisphere. The common biology process of TH upstream-inhibited CYFIP2 subnetwork was identified by DAVID, containing feedback SMAD1_2, downstream FOXN3_2, second-core CYFIP2, first-core TH as protein binding; feedback SMAD1_2, downstream FOXN3_2 as transcription factor activity sequence specific DNA binding; downstream ARHGAP12, second-core CYFIP2 as small GTPase mediated signal transduction; The common cellular component of feedback SMAD1_2, downstream FOXN3_2, second-core CYFIP2, first-core TH as nucleus; feedback SMAD1_2, downstream ARHGAP12, second-core CYFIP2, first-core TH as cytosol; feedback SMAD1_2, second-core CYFIP2, first-core TH as cytoplasm; second-core CYFIP2, first-core TH as neuron projection; The common tissue distributions as ADIPOCYTE_3rd, CD8+T cells_3rd, PLACENTA_3rd, salivarygland_3rd maybe exist the same pattern with human left hemisphere. We propose and mutual positively verify tyrosine hydroxylase (TH) upstream-inhibited cytoplasmic FMR1 interacting protein 2 (CYFIP2) subnetwork for learning in human left hemisphere|ADIPOCYTE|CD8+T cells|PLACENTA|salivarygland via cytoplasm to nucleus small GTPase mediated signal transduction. | |||
| TO cite this article:ZHANG Weijian,HUANG Juxiang,WANG Lin. TH upstream-inhibited CYFIP2 subnetwork for learning via cytoplasm to nucleus small GTPase mediated signal transduction[OL].[23 December 2019] http://en.paper.edu.cn/en_releasepaper/content/4750249 | |||
| 6. TH upstream-inhibited ARHGAP12 subnetwork for learning in human left hemisphere|CD8+T cells|PLACENTA via cytosol positive regulation of transcription | |||
| CUI Xuelei,WANG Lin,HUANG Juxiang | |||
| Biology 21 December 2019 | |||
| Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
| Abstract:High tyrosine hydroxylase (TH) upstream-inhibited Rho GTPase activating protein 12 (ARHGAP12) molecular subnetwork was constructed, including upstream cytoplasmic FMR1 interacting protein 2 (CYFIP2), NCK adaptor protein 2 (NCK2), retinoblastoma binding protein 6 (RBBP6); downstream forkhead box N3 (FOXN3_2), SMAD family member 1 (SMAD1_2), sulfotransferase family 1A member 2 (SULT1A2) reported relation with learning in human left hemisphere. The common biology process of TH upstream-inhibited ARHGAP12 subnetwork was identified by DAVID, containing upstream CYFIP2, upstream NCK2, upstream RBBP6, downstream FOXN3_2, downstream SMAD1_2, downstream SULT1A2, first-core TH as protein binding; upstream CYFIP2, second-core ARHGAP12 as small GTPase mediated signal transduction; upstream CYFIP2, upstream NCK2 as vascular endothelial growth factor receptor signaling pathway; upstream NCK2, downstream SMAD1_2 as signal transduction, negative regulation of cell proliferation, positive regulation of transcription from RNA polymerase II promoter; upstream NCK2, second-core ARHGAP12 as positive regulation of GTPase activity; downstream FOXN3_2, downstream SMAD1_2 as transcription factor activity sequence specific DNA binding; downstream SULT1A2, first-core TH as small molecule metabolic process; The corresponding common cellular component of upstream CYFIP2, upstream NCK2, downstream SMAD1_2, downstream SULT1A2, second-core ARHGAP12, first-core TH as cytosol; upstream CYFIP2, upstream NCK2, upstream RBBP6, downstream SMAD1_2, first-core TH as cytoplasm. The corresponding common tissue distributions as CD8+T cells_3rd, PLACENTA_3rd maybe exist the same pattern with human left hemisphere. We propose and mutual positively verify tyrosine hydroxylase (TH) upstream-inhibited Rho GTPase activating protein 12 (ARHGAP12) subnetwork for learning in human left hemisphere|CD8+T cells|PLACENTA via cytosol positive regulation of transcription. | |||
| TO cite this article:CUI Xuelei,WANG Lin,HUANG Juxiang. TH upstream-inhibited ARHGAP12 subnetwork for learning in human left hemisphere|CD8+T cells|PLACENTA via cytosol positive regulation of transcription[OL].[21 December 2019] http://en.paper.edu.cn/en_releasepaper/content/4750284 | |||
| 7. Comparing gene co-expression networks and modules across 52 tissues | |||
| Tian Yingxiang,海南师范大学，数学与统计学院，海口，570100,Liao Bo | |||
| Biology 05 May 2019 | |||
| Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
| Abstract:The genotype-tissue expression project collects and analyzes a variety of human tissues from donors of the same dense genotype. The Weighted Gene Co-Expression Network (WGCNA) method can construct networks based on the similarity of gene expression data between the two genes to discover inter-gene relationships. This study aims to discover inter-organizational relationships by building the networks of tissues based on weighted gene co-expression network methods and the tissue gene expression profiles provided by GETX. In the experiment, the network was constructed for each tissue, and the hypothesis test was used to analyze the intern-organizational correlation. Combined with some gene ontology function enrichment analysis, the common functional characteristics among all the tissues and some immune function enrichment situation was found. After that, correlation analysis is performed on the modules generated by the tissue network, the maximum group analysis of the module network is performed, and the modules which highly enriched immune functions are analyzed. | |||
| TO cite this article:Tian Yingxiang,海南师范大学，数学与统计学院，海口，570100,Liao Bo. Comparing gene co-expression networks and modules across 52 tissues[OL].[ 5 May 2019] http://en.paper.edu.cn/en_releasepaper/content/4748667 | |||
| 8. Research progress of peptide durgs discovery | |||
| Yin Xinong,Wu Lei | |||
| Biology 18 November 2018
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| Abstract:Peptides are a kind of active substances composed of amino acids, which play an important role in various progress of life activities, including immune defense, cell proliferation/differentiation, tumor pathological changes and so on. Since the first synthetic bioactive peptide was born in 1953, more than 80 polypeptide drugs have been listed in the global market, including some "blockbuster" drugs with sales of more than $1 billion. A large number of peptide drugs have entered the clinical trial or declaring stage. There are many unique advantages of peptide drugs: remarkable effectivity and specificity, less toxicity, low probability to accumulate in the body tissues and a handful of interaction with other drugs. Thus, more and more peptide drugs are widely used in the prevention, diagnosis and treatment of diabetes, tumors, cardiovascular diseases and hepatitis. This article reviewed the current research progress of peptide drugs, and prospects the great development of peptide drugs in the future. | |||
| TO cite this article:Yin Xinong,Wu Lei. Research progress of peptide durgs discovery[OL].[18 November 2018] http://en.paper.edu.cn/en_releasepaper/content/4746489 | |||
| 9. Environmental and spatial effects on the Qinghai-Tibet plateau plant community species composition | |||
| Jia Peng,Jia Peng,Ma Yanqi,Du Guozhen | |||
| Biology 08 November 2018
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| Abstract:Community structure is the focus of community ecology. Comparing the relative contribution of environmental and spatial variables on species composition is essential to understand the process of community assembly. In this study, we explored that the effects of regional spatial scale, local spatial scale and environmental variables on the species composition of meadow and steppe on the Qinghai-Tibet plateau. The results showed that environmental, regional and local spatial scale variables had significant effects on meadows and their functional groups, and the explanation of local spatial variables was relatively high. And the regional spatial scale variable had a significant effect on the species composition of the steppes and their functional groups. In addition, the total explanation of environmental and spatial variables accounted the highest for the legume groups species composition at the sample sites. And the sum of the explanation of impact factors on meadow functional groups was not equal to the effect on meadow species composition, and the same phenomenon in the steppe. The results demonstrated that environmental and spatial variables and the division of functional groups could fully detect and explain the species composition of community on the Qinghai-Tibetan Plateau. | |||
| TO cite this article:Jia Peng,Jia Peng,Ma Yanqi, et al. Environmental and spatial effects on the Qinghai-Tibet plateau plant community species composition[OL].[ 8 November 2018] http://en.paper.edu.cn/en_releasepaper/content/4746329 | |||
| 10. DDX3Y Computational Catalytic Network Construction and Analysis between Left Brain of Chimpanzee and Human | |||
| LIU Xiaoxiao,HUANG Juxiang,WANG Lin | |||
| Biology 07 November 2018
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| Abstract:DDX3Y computational catalytic network construction and analysis of human left brain is very useful to identify novel markers and potential targets for the understanding of brain mechanism. By integration of gene regulatory network infer (GRNInfer) and the database for annotation, visualization and integrated discovery (DAVID 2010 version) we identified and constructed significant molecule DDX3Y catalytic network from 15 chimpanzee and 14 human left brain samples in the same GEO Dataset GDS2678. Our result verified DDX3Y catalytic module only in the downstream of chimpanzee left brain (AGL, PDIA2, PPID, RBBP6 activation; ENOSF1, GSTM3, RECQL, RPP14 inhibition) and downstream (DDX19A, ENPP2, RPP14, SPTLC1activation; AGL, ENOSF1, GSTM3, RECQL, HERC2P2, HERC2P3, PCSK6, PDE8A, PDIA2, PPID, RBBP6 inhibition), whereas in the upstream of human left brain (GSTM3, HSD17B6, PCSK6 activation; EGFR, ENOSF1 inhibition) and downstream (AGL, DDX19A, EGFR, HSD17B6 activation; ABCC10, ENPP2, GSTM3, HERC2P3, PCSK6, PDE8A, PDIA2, PPID, RECQL, SPTLC1 inhibition). Importantly, we datamined that DDX3Y catalytic cluster of human left brain is involved in nervous system development, ubl conjugation, response to chemical stimulus, neurogenesis, cell development and cognition, regulation of apoptosis, anatomical structure development, ATPase activity, coupled, endoplasmic reticulum, polysaccharide binding, pyrophosphatase activity, cellular localization, transport and calcium ion binding (only in human left brain terms) without Isomerase and zinc ion binding (only in chimpanzee left brain terms), the condition is vital to central nervous system development and cognition of human left brain. Our result demonstrated that common terms in both chimpanzee and human left brain include phosphoprotein, hydrolase, organelle, metabolic process, nucleic acid binding, metal-binding, acetylation, DNA binding, Golgi apparatus, identical protein binding, homeostatic process, signal transducer activity, membrane, developmental process, glycoprotein, cytoskeletal protein binding, regulation of cellular process and biosynthetic process, and these terms are more relative to development and cognition, therefore we deduced the stronger DDX3Y catalytic network in human left brain consistent with our number computation. It would be necessary of the stronger DDX3Y catalytic function to development and cognition of human left brain. | |||
| TO cite this article:LIU Xiaoxiao,HUANG Juxiang,WANG Lin. DDX3Y Computational Catalytic Network Construction and Analysis between Left Brain of Chimpanzee and Human[OL].[ 7 November 2018] http://en.paper.edu.cn/en_releasepaper/content/4746419 | |||
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