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1. Comparison of Sequence and Structure of Loop Regions in Lipases: Discovery of a Novel Mutable Domain | |||
Xu Yun,Shen Kunlong,Hu Suyuan,Wu Hongyi,Zhou Zhiliang,You Yuanming,Zhao Yi-Lei | |||
Biology 03 March 2014 | |||
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Abstract:Lipases (EC 3.1.1.3) possess two critical conformations, "open" and "close", during their catalytic process. The conformational changes, caused by the flexible loop regions in the enzymes, determine selectivity, regioselectivity and stereoselectivity of substrates in the enzymatic reactions. However, the principles beneath the phenomenon have not been clearly understood thoroughly yet, in terms of mutability on these loop regions. This paper employed both sequence and structure bioinformatical methods to study lipases available in database, especially for loop regions such as the 'lid' domain that was widely reported to connect substrate selectivity. Unsurprisingly, the 'lid' domain is quite mutable in a group of lipases which are in a moderate similarity for sequence and structure. However, we have found a more mutable, even the most mutable, domain among these loop regions. Loop 9, a very close to C terminus, is ranked top 1. The new discovery may rationalize the coupling effect from colipase. | |||
TO cite this article:Xu Yun,Shen Kunlong,Hu Suyuan, et al. Comparison of Sequence and Structure of Loop Regions in Lipases: Discovery of a Novel Mutable Domain[OL].[ 3 March 2014] http://en.paper.edu.cn/en_releasepaper/content/4587910 |
2. The conservative gene regulatory network in HK97 and λ phages | |||
Ai Duiyuan,Qi Yanjiao | |||
Biology 08 June 2009 | |||
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Abstract:Some conservative gene regulatory elements are found in Enterobacteria phage HK97 through sequences alignment, which are very similar to λ phage. Meanwhile, the regulated genes such as c1-gene, cro-gene, Q-gene, also show homology with λ phage. All of these results suggest hk97’s gene regulatory network is as same as λ phage. It implies this regulatory network is crucial and universal to lambda group. | |||
TO cite this article:Ai Duiyuan,Qi Yanjiao. The conservative gene regulatory network in HK97 and λ phages[OL].[ 8 June 2009] http://en.paper.edu.cn/en_releasepaper/content/32942 |
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