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1. Glutamine Supplementation Protects against Experimental Antibiotic-associated Diarrhea | |||
Mao Jinyan,Li Haitao | |||
Food Science and Technology 05 March 2019 | |||
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Abstract:Diarrhea is a major adverse effect of antibiotic use; however, no known medical regimen is available yet. Glutamine has a pivotal role in intestinal homeostasis, but its implication in antibiotic-associated diarrhea (AAD) remains unclear. Herein we explored the potential of glutamine supplementation in AAD management by using a preclinical mouse model. Data clearly showed that upon clindamycin exposure glutamine store was depleted in colonic mucosa, whereas glutamine supplementation improved several symptoms of experimental AAD. Mechanistically, clindamycin treatment substantially confounded gut microbiota especially in butyrate-producing strains, thereby leads to fecal butyrate deficiency, and in turn increases the body\'s demand for glutamine. Protective effect of glutamine supplementation on AAD may, at least in part, be explained by restoring the intestinal mucosal barrier and facilitating antimicrobial host defense. Taken together, our findings in this study provided a valuable rationale for guiding the clinical uses of glutamine in AAD management. | |||
TO cite this article:Mao Jinyan,Li Haitao. Glutamine Supplementation Protects against Experimental Antibiotic-associated Diarrhea[OL].[ 5 March 2019] http://en.paper.edu.cn/en_releasepaper/content/4747583 |
2. Immunomodulatory effects of Lactobacillus casei Zhang in a murine model of peanut allergy | |||
Mengsha Hu,Qiuxiang Zhang,Xiaoming Liu,Gang Wang,Hao Zhang,Wei Chen | |||
Food Science and Technology 14 March 2013 | |||
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Abstract:Probiotics can modulate systemic and mucosal immune systems, as well as induce immune tolerance in allergic diseases. The aim of this study was to evaluate the immunomodulatory potential of Lactobacillus casei Zhang on prophylactic and therapeutic effects in a mouse model of peanut allergy. Intragastrical administration with L. casei Zhang, prior or after allergic sensitization, led to increased levels of serum allergen-specific IgG2a and mucosal IgA antibodies. Additionally, systemic anaphylactic symptoms and Th2 responses (IgE antibody, histamine release and IL-4 production) were attenuated. L. casei Zhang had less influence on the serum IgG1 antibody and other cytokines (IL-10, IL-12 and IFN-γ). Successful immunomodulation by pre and post-treatment were further demonstrated by an augment of the IFN-γ/IL-4 ratio in vitro and enrichment of CD4+ Foxp3+ Tregs in spleen and mesenteric lymph nodes. These results suggested that L.casei Zhang may play a role in preventing and treating peanut allergy. | |||
TO cite this article:Mengsha Hu,Qiuxiang Zhang,Xiaoming Liu, et al. Immunomodulatory effects of Lactobacillus casei Zhang in a murine model of peanut allergy[OL].[14 March 2013] http://en.paper.edu.cn/en_releasepaper/content/4530123 |
3. In vitro screening of lactobacilli with antagonistic activity against Campylobacter jejuni growth and infection in human intestinal epithelial cells | |||
Yu Zhao,Fengwei Tian,Haiqin Chen,Xiaoming Liu,Gang Wang,Qiuxiang Zhang,Jianxin Zhao,Hao Zhang,Wei Chen | |||
Food Science and Technology 19 March 2012 | |||
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Abstract:Campylobacter jejuni is identified as the leading bacterial pathogen causing enterocolitis in human, usually leading to watery or bloody diarrhea, abdominal pain. Previous studies reported that some lactic acid bacteria have inhibitory effects on pathogenic bacteria, however the protective effects of lactobacilli strains on infection with C.jejuni have not been extensively studied. In this study, seventy-eight lactobacilli strains were screened for anti-C.jejuni activity using well diffusion agar assays and the ability of adhesion to human intestinal epithelial (HT-29) cell were also assessed. Four lactobacilli strains, i.e, strain N8, N9, ZL4 and ZL5, showed obvious potential anti-C.jejuni growth in vitro as well as their significant ability of adhesion to the HT-29 cell. Furthermore, these four lactobacilli strains showed significant potential for reducing adhesion and invasion of C.jejuni to HT-29 cell in exclusion, competition and displacement assays, respectively. All the four strains also performanced a desired resistance to the simulated gastrointestinal conditions. Taken together, this study suggests that lactobacilli strains, N8, N9, ZL4 and ZL5 could be used as potential probiotics for prevention infection with C.jejuni . | |||
TO cite this article:Yu Zhao,Fengwei Tian,Haiqin Chen, et al. In vitro screening of lactobacilli with antagonistic activity against Campylobacter jejuni growth and infection in human intestinal epithelial cells[OL].[19 March 2012] http://en.paper.edu.cn/en_releasepaper/content/4472323 |
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