Select Subject

All (8828)

Agronomy (158)

Animal Husbandry,... (64)

Aquatic Science (16)

Astronomy (36)

Aviation (22)

Basic Medicine (184)

Biology (504)

Chemical Engineering (103)

Chemistry (635)

Civil and Archite... (105)

Clinical Medicine (236)

Computer Science ... (924)

Dynamic and Elect... (121)

Earth Science (119)

Economics (67)

Education (31)

Electrics, Commun... (927)

Energy Science an... (67)

Engineering and T... (15)

Environmental Sci... (140)

Food Science and ... (63)

Forestry (36)

Hydraulic Enginee... (40)

Mechanics (240)

Metallurgical Eng... (32)

Mine Engineering ... (38)

Nuclear Science a... (21)

Pharmacy (98)

Physics (920)

Preventive Medici... (37)

Psychology (20)

Security Science ... (17)

Sports Science (6)

Surveying and Map... (15)

Textile Science a... (16)

Traditional Chine... (56)

Transportation En... (57)

Select/Unselect all

For Selected Papers

Saved Papers

Please enter a name for this paper to be shown in your personalized Saved Papers list


	1. Ultrastructure of mouse thin limbs of Henle's loops based on serials sections and 3D reconstuction
	WEN Yu,ZHAI Xiaoyue
	Basic Medicine 03 March 2014
	Show/Hide Abstract \| Cite this paper︱Full-text: PDF (0 B)

	Abstract:Thin limbs of the long looped nephrons (LLN) are of heterogenic ultrastructure and transportation, which is important for formation of the gradient osmolarity in renal medulla and therefore the concentrated urine. Here presented a detailed description of the epithelia, including ultra-structure and length and location of the epithelial types and subtypes of the descending thin limbs (DTL), as well as ascending thin limbs (ATL), of the LLN. Three adult C57/BL/6J mice were used for kidney tissue serial sections and computer assisted 3D reconstruction of nephrons. Based on tubular tracing, sections representing different epithelial types of DTL and ATL of the LLN were selected and re-embedded in Epon for the ultrastructural analysis. Three epithelial types, type-2, -3, and -4 in sequence are of their own ultrastructural features, running courses, and the spatial locations in renal medulla. Type-2 epithelium constituted the upper part of the DTL for a various distance, about (53.51±5.05)%, located in the outer two thirds of the inner stripe of the outer medulla (ISOM); while type 3 epithelium lined the middle part (38.47±3.06)% of the DTL, started at the border of the outer two thirds and inner one third of the ISOM, ended at the lower 1/5 to 1/4 of the whole length of the DTL, at the various levels of the inner medulla (IM); and type-4 lined the last part of the DTL for various distances, and constituted the pre-bend part of the DTL and the whole length of the ATL. For the individual nephrons, the location of the transition between type-2 and -3 was almost consistent, while the transition of the type-3 and -4 was at the various levels of the IM. According to the ultrastructure, traditional type-2 epithelium was subdivided into type-2a, -2b, and -2c. Type-2a constituted initial part of the DTL of LLN with highly complex ultrastructure and tortuous course for various distances, whereas type-2b and -2c were structurally less complex with less tortuous course, compared with type-2a, and gradually transferred into type-3 around the border of outer and inner medulla (check). In conclusion, different epithelial types and subtypes along DTL and ATL were arranged in a regular sequence, but of various lengths and locations, suggesting regional or segmental transportation properties.
	TO cite this article:WEN Yu,ZHAI Xiaoyue. Ultrastructure of mouse thin limbs of Henle's loops based on serials sections and 3D reconstuction[OL].[ 3 March 2014] http://en.paper.edu.cn/en_releasepaper/content/4588604


	2. Effect of consumption of olestra or regular triglyceride cake on gastrointestinal symptoms
	DOU Yujing,LIU Jing,ZHU Jing,LIU Yuanfa,WANG Xingguo
	Basic Medicine 05 December 2012
	Show/Hide Abstract \| Cite this paper︱Full-text: PDF (0 B)

	Abstract:Background: olestra is a new type of fat substitutes. Because it is not absorbed, it may cause gastrointestinal Symptoms when consumed in large amounts. Objective: The aim was using cake as the carrier of olestra to compare the effect of gastrointestinal symptoms in people when consumed in different amounts. Methods: A randomized, double-blind, placebo-controlled trial compared the effects of olestra cake (11g/day or 22g/day in cake) with those of regular butter cake on gastrointestinal symptoms. The study lasted 9 days: 3days baseline and 6 days treatment. The gastrointestinal symptoms and their impact on daily activities were collected by telephone interviewers and recorded in a daily record. Results: Gastrointestinal symptoms, such as diarrhea, abdominal pain, flatulence, nausea, loose stools, more frequent bowel movement and so on, were observed in our study. The incidence of diarrhea (liquid/watery stools, bowel movement frequency ＞ 3/day) which people and researchers paid more attention to was only 0.79% when one participant consumed 11g olestra. Of 63 evaluable subjects in the olestra cake group (22g/day) or in the butter cake group, incidence of GI adverse events was 1.6% lower than the incidence consumed 11g/day (6.4%). There was not significant difference between different intake doses in the incidence of gastrointestinal adverse events by chi-square (p=0.371>0.05). The incidence of gastrointestinal function change had a growing trend with the increase of olestra intake. But it is not significant by chi-square (p=0.541>0.05). Gastrointestinal symptoms, such as diarrhea, abdominal pain, flatulence, nausea, loose stools, mainly occurred in the first day after eating up cake, while more frequent bowel movement mainly occurred in the first and second day. The effect of sex and age on the incidence of gastrointestinal symptoms was not significant. Conclusions: This study demonstrates that consumption of olestra is not associated with increased incidence or severity of gastrointestinal symptoms. So it is safe and acceptable that olestra, as fat replacer, is applied in food.
	TO cite this article:DOU Yujing,LIU Jing,ZHU Jing, et al. Effect of consumption of olestra or regular triglyceride cake on gastrointestinal symptoms[OL].[ 5 December 2012] http://en.paper.edu.cn/en_releasepaper/content/4499614


	3. The expression and significance of androgen receptor in HBV-associated chronic liver diseases
	Zhu Rong,Gu Dong-Hua
	Basic Medicine 20 January 2011
	Show/Hide Abstract \| Cite this paper︱Full-text: PDF (0 B)

	Abstract:Purpose:To explore the AR and HBx expression in both mRNA levels and protein levels, and to find the relationship among them and clinical characteristics. Compared with the negative controls, we tried to find the role of AR in HBV-associated hepatocarcinogenesis. Methods: Eighty-three cases of surgically resected HBV-associated HCC and 14 cases of the HBV-negative HCC were selected. Meanwhile, 13 peritumoral liver tissues from hemangioma served as benign control. One hundred and eighty-nine liver biopsy samples of chronic hepatitis B and 75 cases whose diagnosis as "No pathological diagnostic abnormal" were also selected. The expressions at mRNA levels were detected by fluorescence quantitative real-time RT-PCR. Western blot and En Vision immunohistochemical stain investigated the protein expressions. Results: In 83 HBV-associated HCC cases, in both peritumoral tissues (P=0.000) and tumors (P=0.000), AR mRNA levels correlated positively with HBx; The expression of AR (P=0.011) and HBx (P=0.000) was significantly higher in peritumoral tissues than in tumors; HBV-associated HCC cases had significantly higher AR mRNA than HBV-negative HCC in both peritumoral tissues (P=0.027) and tumors (P=0.021). The results from western blot analysis and Immunohistochemical stain were consistent with those of mRNA levels.In chronic hepatitis B patients, the expression of AR correlated with the grade of Scheuer scores (P=0.034). Conclusions: To clarified the expression of AR in HBV-associated HCC and chronic hepatitis B cases. AR plays a role in HBV-associated hepatocarcinogenesis. HBx-induce AR expression may be a mechanism of hepatocarcinogenesis. AR had stronger expression in peritumoral tissues than in tumors implied that the expression of AR increases during preneoplastic stages and that progression towards cancer development can suppress maintain AR expression levels. It is therefore proposed that androgen therapy may be ineffective after establishment of tumor. In chronic hepatitis B, AR pathway may be related with inflammation.
	TO cite this article:Zhu Rong,Gu Dong-Hua. The expression and significance of androgen receptor in HBV-associated chronic liver diseases[OL].[20 January 2011] http://en.paper.edu.cn/en_releasepaper/content/4408010


	4. The dose distribution detection design of fragments for heavy ions therapy
	Xinjian Tan
	Basic Medicine 24 March 2008
	Show/Hide Abstract \| Cite this paper︱Full-text: PDF (0 B)

	Abstract:The charged ions have been used in tumor therapy instead of conventional radiation therapy since 1970’s mainly as its favorable depth profile of the relative biological effectiveness (RBE). However, the projectiles fragments produced inside patient’s body reach a region beyond the range of the primary particles, and cause needless exposure, known as ‘fragment tail’, which spoil the therapy effect seriously. The production of fragments is one of the most crucial, but not yet perfectly understood, problems to be considered when planning for the utilization of heavy ions therapy, and there is no detailed experimental description about the dose distribution it caused until now. In this paper, we introduce a method of detecting the light fragments briefly with the aim of giving a feasible way to measure the spatial dose distribution behind the Bragg peak or Spread out Bragg peak (SOBP) using the CR-39 solid state nuclear track detector, the HSP-1000 microscope system and the PitFit track measurement analysis software.
	TO cite this article:Xinjian Tan. The dose distribution detection design of fragments for heavy ions therapy[OL].[24 March 2008] http://en.paper.edu.cn/en_releasepaper/content/19622


	5. Intragastric Administration of Evodiamine Reduces NPY and AGRP Gene Expression in The Hypothalamus and Decreases Food Intake in Rats
	Jinghong Shi,Jianqun Yan,Qi Lei,Junjie Zhao,Ke Chen,Dejun Yang,Xiaolin Zhao
	Basic Medicine 28 January 2008
	Show/Hide Abstract \| Cite this paper︱Full-text: PDF (0 B)

	Abstract:Evodiamine (Evo), an alkaloidal component extracted from the fruit of Evodiae fructus (Evodia rutaecarpa Benth., Rutaceae), decreases the body weight of rats through a poorly defined mechanism. The hypothalamus is responsible for controlling food intake and energy expenditure. We postulate that Evo mediates this activity by modulating feeding-related peptides in the hypothalamus. We investigated the effects of Evo on food intake, body weight and the mRNA expression of hypothalamic NPY, AGRP, Pmch, POMC, CART, and MC4R, in male rats. Evo (40 mg/kg or 4 mg/kg) was intragastrically administrated for 25 days, and the food intake and body weight of rats were recorded daily. Blood samples were collected for leptin radioimmunoassay (RIA). Real-Time PCR was used to analyze the mRNA expression. Our results show that intragastric administration of Evo (40 mg/kg) inhibits food intake, decreases body weight and reduces the mRNA expression of NPY and AGRP in the hypothalamus, while it increases the circulating level of leptin. Our results indicate that Evo decreases food intake, and therefore body weight, partly by down-regulating NPY and AGRP mRNA expression in the hypothalamus.
	TO cite this article:Jinghong Shi,Jianqun Yan,Qi Lei, et al. Intragastric Administration of Evodiamine Reduces NPY and AGRP Gene Expression in The Hypothalamus and Decreases Food Intake in Rats[OL].[28 January 2008] http://en.paper.edu.cn/en_releasepaper/content/18417

Select/Unselect all

For Selected Papers

Saved Papers

Please enter a name for this paper to be shown in your personalized Saved Papers list

Second-level Subject

Biomedical Engineering(43)
Human Anatomy(4)
Human Histology and Embry...(7)
Human Immunology(11)
Human Physiology(11)
Medical Biochemistry(13)
Medical Cell Biology(18)
Medical Genetics(5)
Medical Laboratorial Zoology(2)
Medical Microbiology(11)
Medical Parasitology(1)
Medical Statistics(2)
Other Subjects of Basic M...(3)
Pathology(29)
Pharmacology(22)
Radioactive Medicine(1)

Rank

Alert Name:
Alerting to:
Authentication email will be sent to your email address in 24 hours
Frequency:
Email Message Format:	Plain text Graphical(HTML)

Complete the form below and we will recommend the selected titles to your friends on your behalf. * Indicates a required field.
Your name*:
Your email address*:
Recipient's name*:
Recipient's email address*:
(multiple recipient's names and email addresses should be separated with semicolons)
Your comments:	I thought you would find the page(s) useful.

Your name:
Your email address:
Recipient's name:
Recipient's email address:
(multiple recipient's names and email addresses should be separated with semicolons)
Your comments:	I thought you would find this page useful.

Disclaimer: This message was sent to your friend using the "Send it to a friend" facility on the Sciencepaper Online’ WWW site, http://www.paper.edu.cn/en. The Sciencepaper Online is not responsible for the content of this email, and anything said in this email does not necessarily reflect the Sciencepaper Online's views.

	Check out RSS, or use RSS reader to subscribe this item