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1. Xylocarpin H, a component of Xylocarpus granatum, produces antidepressant-like activities in mice | |||
YIN Xi,LI Xin,HAO Yaoguang,ZHAO Yiwen,ZHOU Jinghong,SHI Haishui | |||
Basic Medicine 26 November 2014 | |||
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Abstract:Major depression is a common psychiatric disorder worldwide that imposes a substantial health burden on society. Currently available antidepressants do not meet the clinical needs. Here, we report that Xylocarpin H, an active component of Xylocarpus granatum, has antidepressant-like effects in mouse models of depression. In mouse forced swimming- and tail suspension tests, two validated models of depression, oral administration of Xylocarpin H resulted in a dose-dependent decreased immobility duration within the dose range of 15-50 mg/kg. In addition, Xylocarpin H dose-dependently increased the time in the central zone at doses of 5-50 mg/kg in the locomotion activity test. The antidepressant-like activities of Xylocarpin H were associated with its inhibitory effects on hypothalamic-pituitary-adrenal (HPA) axis' hyperactivity in response to acute stress. Interestingly, these effective doses of Xylocarpin H did not affect locomotor- and HPA axis activities in the absence of stress. In summary, the present study, for the first time, demonstrated that Xylocarpin H exerts antidepressant-like effects in mouse behavioral models of depression, likely by inhibiting HPA axis systems. These data provide a strong basis for developing Xylocarpin H as a novel antidepressant agent for the treatment of major depression disorders. | |||
TO cite this article:YIN Xi,LI Xin,HAO Yaoguang, et al. Xylocarpin H, a component of Xylocarpus granatum, produces antidepressant-like activities in mice[OL].[26 November 2014] http://en.paper.edu.cn/en_releasepaper/content/4620567 |
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