Abstract:Objectives: To investigate the clinicopathological features of anaplastic large-cell lymphoma (ALCL) and explore the optimal treatment strategies. Methods: Sixty-four primary systematic ALCL patients who were diagnosed and treated in our hospital were studied retrospectively. Results: Our data confirmed the male predominance, young age of onset and frequent presence of adverse factors such as B symptoms and involvement of extranodal sites in ALCL patients. However, patients with stage Ⅲ/Ⅳ disease and elevated LDH were less frequent in our study. Chemotherapy including CHOP and proMACE/cytaBOM was administrated in 46 and 9 patients, respectively. No significant difference can be seen in terms of response rate and survival between these two groups. Altogether, 16 patients received peripheral blood stem cell transplantation (PBSCT). Although significantly higher proportion of patients in transplantation group had state Ⅲ/Ⅳ disease, the long-term survival was comparable with that of patients received conventional chemotherapy. Anaplastic lymphoma kinase (ALK) was an independent prognostic factor, especially for adult ALCL patients, whose expression indicated significantly high long-term survival. Conclusions: CHOP is still the first-line chemotherapy regimen for ALCL patients due to its less toxicity and comparable efficacy with third-generation regimen. Patients with advanced disease may potentially benefit from PBSCT.

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	1. Clinicopathological features and optimal treatment strategies for ALCL patients
	He Xiaohui,Shi Yuan-kai,Li Bo
	Clinical Medicine 13 January 2009
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	Abstract:Objectives: To investigate the clinicopathological features of anaplastic large-cell lymphoma (ALCL) and explore the optimal treatment strategies. Methods: Sixty-four primary systematic ALCL patients who were diagnosed and treated in our hospital were studied retrospectively. Results: Our data confirmed the male predominance, young age of onset and frequent presence of adverse factors such as B symptoms and involvement of extranodal sites in ALCL patients. However, patients with stage Ⅲ/Ⅳ disease and elevated LDH were less frequent in our study. Chemotherapy including CHOP and proMACE/cytaBOM was administrated in 46 and 9 patients, respectively. No significant difference can be seen in terms of response rate and survival between these two groups. Altogether, 16 patients received peripheral blood stem cell transplantation (PBSCT). Although significantly higher proportion of patients in transplantation group had state Ⅲ/Ⅳ disease, the long-term survival was comparable with that of patients received conventional chemotherapy. Anaplastic lymphoma kinase (ALK) was an independent prognostic factor, especially for adult ALCL patients, whose expression indicated significantly high long-term survival. Conclusions: CHOP is still the first-line chemotherapy regimen for ALCL patients due to its less toxicity and comparable efficacy with third-generation regimen. Patients with advanced disease may potentially benefit from PBSCT.
	TO cite this article:He Xiaohui,Shi Yuan-kai,Li Bo. Clinicopathological features and optimal treatment strategies for ALCL patients[OL].[13 January 2009] http://en.paper.edu.cn/en_releasepaper/content/27710


	2. Regulation of Gonadotropin-Releasing Hormone Receptor-I (GnRHR-I) Expression in Pituitary and Ovary by GnRH agonist (GnRH-a) and GnRH antagonist (GnRH-ant)
	Ping Peng,Yaqin Mo,Ran Zhou,Dongzi Yang
	Clinical Medicine 09 January 2009
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	Abstract:
	TO cite this article:Ping Peng,Yaqin Mo,Ran Zhou, et al. Regulation of Gonadotropin-Releasing Hormone Receptor-I (GnRHR-I) Expression in Pituitary and Ovary by GnRH agonist (GnRH-a) and GnRH antagonist (GnRH-ant) [J].

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	3. Cloning and Transcriptional Activity of a Novel Ovarian- Specific Promoter from Rat Retrovirus-like Elements
	Chunhua Tu,Yaqin Mo,Weipeng Liu,Lili Huang,Dongzi Yang
	Clinical Medicine 09 January 2009
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	Abstract:Tissue-specific promoters were genomic DNA sequences which controlled gene expression in a tissue-dependent manner and/or according to the developmental stage of the organism. The genes driven by these types of promoters would only be expressed in tissues where the gene products were desired, leaving the rest of tissues unmodified. Several promoters have been reported that could specifically control gene expression in an ovarian manner. However, most of them had shortage in research and clinical application. Recently, a family of ovarian-specific transcription units (OSTUs), which was specifically expressed in rat ovary, was identified with a probe generated from the long terminal repeat (LTR) of Moloney murine leukemia virus (MoMLV). In this study, we extracted a retrovirus-like sequence using RT-PCR according to the nucleotide sequences of these transcripts and proved it to be a novel ovarian-specific promoter by SYBR green real-time RT-PCR and transfecting reconstructed vectors, in which enhanced green fluorescence protein gene was under the control of this specific promoter, into ovarian and non-ovarian cell lines.
	TO cite this article:Chunhua Tu,Yaqin Mo,Weipeng Liu, et al. Cloning and Transcriptional Activity of a Novel Ovarian- Specific Promoter from Rat Retrovirus-like Elements [OL].[ 9 January 2009] http://en.paper.edu.cn/en_releasepaper/content/27568


	4. Synchronization of vascularization and neurotization may refine tissue-engineered bone
	Yan xiangzhen,Yang pishan
	Clinical Medicine 03 December 2008
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	Abstract:Although the field of bone tissue engineering has progressed significantly in recent years, the development of structurally ordered tissues has not been accomplished. The major drawbacks of current tissue-engineered bones are disorganized matrix, defective mineralization, low clinical union rate as well as bone healing rate, weak mechanical stability and a reduced osteoblast population and activity. Available studies suggest that angiogenesis is closely associated with bone resorption and bone formation. Moreover, patients with neurological disorders exhibit localized osteopenia, bone fragility and increased fracture rate. It is obvious that the phenomena present in patients with neurological disorders almost coincide with those of tissue-engineered bone. And ongoing research in angiogenesis and neurogenesis has revealed many commonalities between these processes. Therefore, we hypothesize that there is a mutual promotion process between neurogenesis and angiogenesis, and the synchronization of vascularization and neurotization will provide a necessary solution to critical problems in bone tissue engineering. From a clinical standpoint, this hypothesis may throw new light in the treatment of patients with large segmental bone defects, numerous angiogenesis-dependent diseases as well as neurodegenerative diseases.
	TO cite this article:Yan xiangzhen,Yang pishan. Synchronization of vascularization and neurotization may refine tissue-engineered bone[OL].[ 3 December 2008] http://en.paper.edu.cn/en_releasepaper/content/26289


	5. The Association of the Neuronal Protective Effect of Cerebral Ischemic Preconditioning with Concentrations of Extracellular Amino Acids in Rats
	Min Zhang,Wenbin Li,Heshan Mei ,Yong-Li Wang,Li Li
	Clinical Medicine 30 October 2008
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	Abstract:The present study was undertaken to observe changes in concentrations of glutamate, aspartate and γ-aminobutyric acid (GABA) in the CA1 hippocampus during the acquirement of brain ischemic tolerance induced by cerebral ischemic preconditioning (CIP) using cerebral microdialysis and high performance liquid chromatography techniques in rats. An initial, moderate and synchronous increase in glutamate, aspartate and GABA was first evoked by the lethal ischemic insult for 8 min which was verified to induce delayed neuronal death (DND) in the CA1 hippocampus. GABA quickly recovered to and kept at control level after reperfusion, but both glutamate and aspartate levels increased secondly in more magnitudes within the early stage of reperfusion. When the animals were pretreated 2 days before the lethal ischemic insult with a CIP for 3 min which protected the pyramidal neurons against DND normally induced by the lethal brain ischemia, the second peaks of glutamate and aspartate was prevented completely. The results suggested first in vivo that the protective effect of the CIP against DND of pyramidal neurons in the CA1 hippocampus normally induced by lethal brain ischemia might be associated with suppressing the increase in extracellular concentrations of both glutamate and aspartate.
	TO cite this article:Min Zhang,Wenbin Li,Heshan Mei , et al. The Association of the Neuronal Protective Effect of Cerebral Ischemic Preconditioning with Concentrations of Extracellular Amino Acids in Rats[OL].[30 October 2008] http://en.paper.edu.cn/en_releasepaper/content/25259


	6. Dynamic process of phagocytosis and fates of macrophages after their ingestion of apoptotic neutrophils
	Wang Jiong,Huang Wei-Lin,Wang Cheng,Liu Rong-Yu
	Clinical Medicine 07 April 2008
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	Abstract:Clearance of apoptotic neutrophils by macrophages is important for the successful resolution of acute inflammation and homeostasis. In this study, the dynamic process of phagocytosis of apoptotic neutrophils was measured in real time and special attention was paid to the fates of macrophages after their phagocytosis in vitro, we staged the recognition and tethering, internalization, digestion and exocytosis stages of phagocytosis of apoptotic neutrophils. Furthermore we found that some macrophages underwent cell death after their ingestion of apoptotic cells. The dead macrophages consisted of autophagy, apoptosis and oncosis as revealed by transmission electron microscopy and confocal microscopy combined with specific dyes. These results demonstrated that after ingestion of apoptotic neutrophils, macrophages might undergo autophagy and apoptosis. Autophagy of macrophage after ingestion of apoptotic cells may be one of the new mechanisms in immune response.
	TO cite this article:Wang Jiong,Huang Wei-Lin,Wang Cheng, et al. Dynamic process of phagocytosis and fates of macrophages after their ingestion of apoptotic neutrophils[OL].[ 7 April 2008] http://en.paper.edu.cn/en_releasepaper/content/20167


	7. Different expression of cytokine in spleen tissue and macrophage in cirrhotic patients with hypersplenism
	Li Zongfang,Li Aimin,Ma Shangyu,Su Qinghua,Zhang Shu,Liu Xiaogong
	Clinical Medicine 31 March 2008
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	Abstract:Purpose: Hepatitis B virus re-infection is a difficult problem to manage after liver transplantation (LT) in patients with cirrhosis. Whether performing a splenectomy at the time of LT would be beneficial or not remains controversial. This study was designed to investigate the functional changes of splenic macrophages in cirrhotic patients with hypersplenism in order to provide additional evidences by which to assess the value of splenectomy. Methods: Fourteen cirrhotic patients with hypersplenism and six controls were enrolled in the study. Serum lipopolysaccharide (LPS) was detected with a limulus assay. The differential expression of cytokines by splenic tissue and splenic macrophages between the cirrhosis and control groups was compared with cytokine arrays. Furthermore, splenic macrophages were cultured and stimulated with LPS, after which tumor necrosis factor (TNF)-α and interleukin (IL)-12 levels in the supernatant were determined. Results: In cirrhotic patients, serum LPS levels increased significantly. Interferon (IFN)-γ, TNF-β, and transforming growth factor (TGF)-β upregulated, whereas IL-4 and IL-5 levels didn’t change in splenic tissue. TNF-α upregulated significantly, while IL-4 and IL-5 levels had no significant changes in splenic macrophages. The IL-12 levels in culture media of splenic macrophages from cirrhotic patients were significantly lower than in controls after LPS stimulation. Conclusion: Endotoxemia and predominant Th1 inflammation in splenic tissue caused splenic macrophage M1 activation in cirrhotic patients with hypersplenism, but the immune functions of splenic macrophages were impaired.
	TO cite this article:Li Zongfang,Li Aimin,Ma Shangyu, et al. Different expression of cytokine in spleen tissue and macrophage in cirrhotic patients with hypersplenism[OL].[31 March 2008] http://en.paper.edu.cn/en_releasepaper/content/19890


	8. Current perspective on respiratory syncytial virus caused bronchiolitis
	Chang-Chong Li
	Clinical Medicine 13 March 2008
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	Abstract:Bronchiolitis caused by respiratory syncytial virus (RSV) is a common lower respiratory tract infectious disease of young children. In recent years, studies on the link with bronchiolitis and asthma are payed more attention increasingly, especially on those with atopy.This review focus on the epidemiology, immunopathogenesis and development of asthma after bronchiolitis, treatmant and prevention of bronchiolitis may be involved.
	TO cite this article:Chang-Chong Li. Current perspective on respiratory syncytial virus caused bronchiolitis[OL].[13 March 2008] http://en.paper.edu.cn/en_releasepaper/content/19262


	9. Study on coherence alterations in Gamma-band EEG during rest and cognitive task in MCI and AD
	Tao Hua-ying,TianXin
	Clinical Medicine 09 January 2008
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	Abstract:The aim of this study was to investigate whether EEG coherence technique can facilitate the detection of early cognitive decline in elderly; and to determine the brain regions involved. The EEGs during both rest and performance of cognitive tasks in 3 groups of participants were recorded. The 3 groups were Mild Cognitive Impairment (MCI) group, Alzheimer’s disease (AD) group, and the healthy control group. In rest state, coherence value of EEG for AD group was lower than those in the other two groups in channel pairs of Fp2-T4, F4-C4 (P<0.01) and F3-C3, Fp1-T3, P3-O1 (P<0.05). There was no significant difference between the MCI and control groups. In cognitive performing state (counting the target number), coherence of EEGs in all channel connections for AD group were lower compared with MCI and control group. Furthermore, in Fp2-T4 (prefrontal-temporal) and F4-C4 (frontal-central) pairs, MCI group showed significantly lower coherence than that in the control group. The conclusion of this study was that the coherence of EEG seemed to be a useful and sensitive indicator for different stages of cognitive impairment, especially in MCI diagnosis. The early Alzheimer’s disease EEG changes began in frontal lobes.
	TO cite this article:Tao Hua-ying,TianXin. Study on coherence alterations in Gamma-band EEG during rest and cognitive task in MCI and AD[OL].[ 9 January 2008] http://en.paper.edu.cn/en_releasepaper/content/17922


	10. A new PCR- Ligase Detection Reaction (LDR) system for forensic SNP analysis
	weibo liang,lvmeili,liao miao,zhuo wang,yanyun wang,lin zhang
	Clinical Medicine 03 January 2008
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	Abstract:Forensic DNA analysis is routinely performed using polymorphic short tandem repeat (STR) markers. Nevertheless, for degraded or minute DNA samples, analysis of autosomal single nucleotide polymorphisms (SNPs) in short fragments might be more successful. Furthermore Y-chromosomal SNPs analysis is a more useful tool in forensic investigations. Recently most methods of SNPs typing are based on the principle of minisequencing. Here we developed a new SNPs detection system for limited forensic materials based on the Ligase Detection Reaction (LDR) assay. A set of 8 Y-SNPs have been typed in 232 individuals of two different Chinese populations via multiplexed Ligase Detection Reaction assay through the Applied Biosystem 310 after the multiplexed PCR. Three probes for each Y-SNP were designed including one common fluorescence labeled probe and two allele specific probes different in size. All the amplicons are less than 100 bps for easy detection degraded or minute DNA samples. Even though the number of markers in the current system is limited, it can easily be extended to yield a greater power of discrimination. When fully developed, the PCR-LDR analysis provides a promising system for efficient sensitive SNP analysis of forensic samples in the future.
	TO cite this article:weibo liang,lvmeili,liao miao, et al. A new PCR- Ligase Detection Reaction (LDR) system for forensic SNP analysis[OL].[ 3 January 2008] http://en.paper.edu.cn/en_releasepaper/content/17712

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