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1. Value and long-term effect of salvage liver transplantation met Hangzhou criteria. :a report of 51 cases | |||
ZHANG Tong,FU Binsheng,LI Hua,XU Chi,YI Shuhong,Wang Genshu,ZHANG Jian,JIANG Nan,YANG Yang,CHEN Guihua | |||
Clinical Medicine 24 December 2013 | |||
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Abstract:Objective To evaluate clinical application and the long-term effect of salvage liver transplantation(SLT)met Hangzhou criteria. Methods The clinical data of 71 patients who underwent SLT by cadaveric grafts treating for hepatocellular carcinoma met Hangzhou criteria from October 2003 to July 2012 were analyzed retrospectively. Among them, 51 patients (intrahepatic recurrence 46;hepatic failure 5) underwent SLT met the Hangzhou criteria, and 40 patients(intrahepatic recurrence 36;hepatic failure 4) met the Milan criteria . Perioperative factors and survival were compared between two groups. Results All patients were followed up. The follow-up time was from 0 to 101 months (median 38.7 months). During follow-up time,there were 12 patients(24%)with tumor recurrence. Though the chance of tumor recurrence increases 8.3%,the number of recipient increases 27.5% by the use of Hangzhou criteria. There was no statistical difference in terms of anhepatic phase, overall ischaemic time, operative time, blood loss, packed red blood cell transfusion, fresh frozen plasma transfused, complication of transplanted liver, retransplantation rate, perioperative mortality(30-day)rate , perioperative mortality(30-day)rate , tumors recurrence rate between SLT groups met Milan criteria and SLT group met Hangzhou criteria (P>0.05). 1-year,3-year,5-year overall and disease-free survivals were not significantly different (100%、86%、73% versus 98%、82%、72%,χ2=0.05,P=0.82; 97.2%、77.1%、74.1% versus 96%、75%、72%,χ2=0.08,P=0.78, respectively) between the SLT group met Milan criteria and SLT group met Hangzhou criteria . Conclusions Milan criteria is the most appropriate indications for SLT. Hangzhou criteria increases the number of recipient, but it did not significantly increase the chance of tumor recurrence. | |||
TO cite this article:ZHANG Tong,FU Binsheng,LI Hua, et al. Value and long-term effect of salvage liver transplantation met Hangzhou criteria. :a report of 51 cases[OL].[24 December 2013] http://en.paper.edu.cn/en_releasepaper/content/4576908 |
2. Steroid receptor coactivator-3 promotes osteosarcoma progression through upregulation of FoxM1 | |||
GENG Shuo,WANG Xiaoyu,XU Xiaoyan,ZHANG Hepeng,MA Yan,ZHANG Yunqi,LI Baoxin,BI Zhenggang,YANG Chenglin | |||
Clinical Medicine 18 December 2013 | |||
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Abstract:In this Increasing evidence suggest that the three homologous members of steroid receptor coactivator (SRC) family (SRC-1, SRC-2 and SRC-3) play key roles in enhancing cell proliferation in various human cancers, such as breast, prostate and hepatocellular carcinoma. However, the function of SRC-3 in osteosarcoma remains largely unexplored. In the current study, we found that SRC-3, but not SRC-1 and SRC-2, was dramatically up-regulated in human osteosarcoma tissues, compared with adjacent normal tissues. To explore the functions of SRC-3 in osteosarcoma, in vitro studies were performed in MG63 and U2OS cells. SRC-3 overexpression promoted osteosarcoma cells proliferation whereas knockdown of SRC-3 inhibits its proliferation. In support of these findings, we further demonstrated that SRC-3 up-regulated FoxM1 expression through co-activation of C/EBP. Together, our results show that SRC-3 drives osteosarcoma progression and imply it as a therapeutic target to abrogate osteosarcoma. | |||
TO cite this article:GENG Shuo,WANG Xiaoyu,XU Xiaoyan, et al. Steroid receptor coactivator-3 promotes osteosarcoma progression through upregulation of FoxM1[OL].[18 December 2013] http://en.paper.edu.cn/en_releasepaper/content/4571958 |
3. The clinical impact of SYT-SSX fusion gene and other prognostic factors in synovial sarcoma | |||
Ren Tingting,Lu Qunshan,Guo Wei | |||
Clinical Medicine 17 December 2013 | |||
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Abstract:Background The aim of this study is to evaluate distribution and clinical impact of the SS18-SSX fusion gene in patients with synovial sarcoma in China. Methods We collected and analyzed the clinical data of 88 patients using univariate and multivariate survival analysis. HEK 293T and NIH 3T3 cell lines were transfected with the SS18-SSX1 or SS18-SSX2 gene to determine the respective involvement of these fusion genes in cell proliferation and invasiveness. Results Overall survival was significantly better among SS18-SSX2 cases (P=0.001), FNCLCC grade 2 cases (P<0.001), and UICC stage 1 or 2 (P<0.001) by univariate and multivariate survival analysis. SS18-SSX1-positive cells were more proliferative and invasive than SS18-SSX2-positive cells. Conclusion SS18-SSX fusion type is a significant prognostic factor for patients with synovial sarcoma | |||
TO cite this article:Ren Tingting,Lu Qunshan,Guo Wei. The clinical impact of SYT-SSX fusion gene and other prognostic factors in synovial sarcoma[OL].[17 December 2013] http://en.paper.edu.cn/en_releasepaper/content/4575580 |
4. The combined treatment of neurocysticercosis involving both brain and spinal cord :Case report and literature review | |||
ZHANG huaqiu,LIU shengwen,SHU kai,LEI Ting | |||
Clinical Medicine 03 December 2013 | |||
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Abstract:BACKGROUND: Neurocysticercosis involving both brain and spinal cord is quite rare. Until now there are not many experience or standard treatments for that. CASE DESCRIPTION: A 23-year-old male patient presented the symptom of progressive numbness and weakness in the right lower limb. Magnetic resonance imaging (MRI) scans revealed the lesions involving both the spinal cord and the cerebral ventricle system. He underwent L3-5 laminectomy and the excision of extramedullary lesion. A postoperative course of albendazole was given for one month. Histopathological examination confirmed the cysticercosis. His symptom was completely released after operation. MRI showed lesions in the brain and spinal cord disappeared at the follow-up. CONCLUSIONS: Neurocysticercosis involving both the brain and spinal cord are rare and complicate. The combination of surgical and medical therapy could be the better choice for patients to achieve ideal outcome. | |||
TO cite this article:ZHANG huaqiu,LIU shengwen,SHU kai, et al. The combined treatment of neurocysticercosis involving both brain and spinal cord :Case report and literature review[OL].[ 3 December 2013] http://en.paper.edu.cn/en_releasepaper/content/4572201 |
5. Proteomic analysis of human donor liver tissues subjected to ischemia/reperfusion injury during liver transplantation | |||
WU Bin,WU Hongli,CHEN Jianning,HUA Xuefeng,LI Ning,LU Minqiang | |||
Clinical Medicine 20 March 2013 | |||
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Abstract:Purpose: to explore the specific alterations in protein profiles that took place during ischemia/reperfusion injury (I/RI) and find novel therapeutic strategies to reduce I/RI during orthotopic liver transplantation (OLT). Method: we used the comparative proteomic approach of two-dimensional electrophoresis (2-DE) and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) to compare the proteomic profiles of the same donor liver at three different time points: T1, immediately after cardiac arrest of donors (normal control). T2, before portal vein was recirculated (ischemia). T3, two hours after the anastomosis of the hepatic artery (reperfusion). Result: we identified 34 proteins that were significantly altered during I/RI. These differentially expressed proteins were functionally classified into seven categories: metabolic enzyme, molecular chaperone, antioxidant enzyme, cytoskeleton protein, signal transduction protein, cyclin, and binding protein. Among the 34 proteins, nine proteins changed only during ischemia (from T1 to T2) period, eleven proteins changed only during reperfusion (from T2 to T3) period, others changed during both ischemia and reperfusion (from T1 to T3) periods. Conclusion: ischemia and reperfusion during LT may lead to different modifications of the liver proteins. Most metabolic enzymes and antioxidant enzymes were up-regulated during ischemia period, indicated that lipidic metabolic disorder and oxidative stress were closely related to the development of ischemia injury. ER chaperones may play a vital role in mediating I/RI and prevention of ER stress caused by I/RI may be used as a key therapeutic target to improve the outcome of LT. | |||
TO cite this article:WU Bin,WU Hongli,CHEN Jianning, et al. Proteomic analysis of human donor liver tissues subjected to ischemia/reperfusion injury during liver transplantation[OL].[20 March 2013] http://en.paper.edu.cn/en_releasepaper/content/4531303 |
6. Squatting or Sitting, which is better for defecation?A research of healthy volunteers | |||
Wang Chen,Cao yongqing | |||
Clinical Medicine 01 March 2013 | |||
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Abstract:Aim Squatting and sitting are the most common positions for defecation, however the mechanisms underlying the effects of different positions on defecation is unclear. This study aimed to observe the general defecation status of healthy volunteers, and compare their manometric profiles and sensory volume with gas or liquid in different positions. Method Ten healthy volunteers with normal bowel and anal function enrolled in the study. A general defecation status form and anorectal manometry was assessed in the squatting, sitting and left lateral position. Results Coordination between the routine and favorite defecation position affected the subject's assessment of difficulty in defecation. The rectal resting pressure was significantly higher in the squatting position (squatting vs sitting, p=0.072 and squatting vs left lateral, p<0.001) and the rectal defecation pressure was significantly lower in the left lateral position (left lateral vs squatting, p=0.001 and left lateral vs sitting, p<0.001). There were no significant differences among the three positions regarding sphincter length, anal resting pressure, maximum voluntary squeeze pressure, anal canal longest contraction time, rectoanal inhibitory reflex present volume and the sensory volume with gas or liquid. The desire to defecate volume (p=0.011) and maximum tolerable volume (p=0.033) were significantly different when the three defecation positions were compared. Conclusion The general defecation status was verified from one individual to another. The rectal resting pressure was higher, and the desire to defecate sensory volume and maximum tolerable volume were lower in the squatting posture. Therefore squatting is more convenient for defecation. In this paper | |||
TO cite this article:Wang Chen,Cao yongqing. Squatting or Sitting, which is better for defecation?A research of healthy volunteers[OL].[ 1 March 2013] http://en.paper.edu.cn/en_releasepaper/content/4525543 |
7. Aesthetic and sensate reconstruction of the fingertip defect with pivot flaps | |||
Ni Feng,Chen Bo,Wang Bin | |||
Clinical Medicine 26 February 2013 | |||
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Abstract:Purpose Sensate reconstruction with glabrous skin is critical for resurfacing the fingertip or pulp defects. Based on the segmental blood supply from the digital artery to the palmar skin and subcutaneous tissue of the digit with accompanied proper digital innervation, the pivot flap was advocated to reconstruct the fingertip defect. Methods From Feb. 2007, 21 patients with fingertip or pulp defects were repaired by pivot flaps in our department. The flap size ranged from 1.8×1.5cm to 2.6×2.2cm. The range of motion of the injured digits was measured. Semmes-Weinstein monofilament test, static and moving 2-point discrimination test was also performed to evaluate the sensory of the flap. Michigan Hand Outcomes Questionnaire (MHQ) was used to investigate the Patients' satisfaction with the appearance of the hand, pain, cold intolerance and percussion tenderness of the repaired fingertip was also examined.Results All flaps survived completely. Full motion was maintained at the distal and proximal interphalangeal joints. The mean values of Semmes-Weinstein score was 3.92 g. The mean values of moving and static 2-point discrimination were 3.9 mm and 4.7 mm, respectively. All patients were satisfied with appearance of the fingertips. No painful tips could be found. All flaps have mild cold intolerance and only 1 of the patients complained of mild tenderness with percussion of the fingertip.Conclusions The pivot flap can provide sensate, glabrous skin and is useful for resurfacing fingertip and pulp defects with an aesthetic and functional outcomes. | |||
TO cite this article:Ni Feng,Chen Bo,Wang Bin. Aesthetic and sensate reconstruction of the fingertip defect with pivot flaps[OL].[26 February 2013] http://en.paper.edu.cn/en_releasepaper/content/4523638 |
8. Prognostic value of circulating DNA in HCC patients underwent liver transplantation | |||
Hu Jie,Wang Zheng,Fan Jia,Zhou Jian | |||
Clinical Medicine 20 February 2013 | |||
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Abstract:Genetic variations play an important role in tumor development and metastasis. Oligonucleotide microarrays were used to evaluate the genetic characteristics of tumor DNA in 30 HCC patients who were underwent LT. Recurrence-related single-nucleotide polymorphism were selected, and their prognostic value was assessed and validated in two independent cohorts of HCC patients, using pretransplant plasma circulating DNA. Prognostic significance was assessed by Kaplan-Meier survival estimates and log-rank tests. rs894151 and rs12438080 were significantly associated with recurrence (P=.003 and P=.004, respectively). Multivariate analyses demonstrated that the co-index of the 2 SNPs was an independent prognostic factor for recurrence (P=.040). Similar results were obtained in the third cohort (N=77). Furthermore, for HCC patients exceeding Milan criteria, the co-index was a prognostic factor for recurrence and survival (P<.001 and P=.002, respectively). Our study demonstrated first that genetic variations of rs894151 and rs12438080 in pretransplant plasma circulating DNA are promising prognostic markers for tumor recurrence in HCC patients undergoing LT. | |||
TO cite this article:Hu Jie,Wang Zheng,Fan Jia, et al. Prognostic value of circulating DNA in HCC patients underwent liver transplantation[OL].[20 February 2013] http://en.paper.edu.cn/en_releasepaper/content/4521474 |
9. Posterior interosseous nerve entrapment after Monteggia fracture-dislocation in children | |||
Li Hai | |||
Clinical Medicine 22 January 2013 | |||
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Abstract:Object Although most of nerve injuries associated with Monteggia fracture-dislocation in children are neurapraxias and will recover spontaneously after conservative treatment, surgical exploration of the involved nerve is always required in the cases with the entrapment of posterior interosseous nerve (PIN). However, the necessity and time frame for surgical intervention for specific patterns of nerve dysfunction remains controversial. Methods Eight cases, six boys and two girls, with Monteggia fracture-dislocation complicated by PIN injury, managed operatively at the authors' hospital from 2007 to 2008 were retrospectively reviewed. All the patients underwent the attempted closed reduction, before they received exploration of PIN, with open reduction and internal fixation or successful closed reduction. Results The PIN was found to be trapped acutely posterior to the radiocapitellar joint in 4 out of 5 Type III Bado's Monteggia fractures. In the remaining cases, since there were longer time intervals from injury to operation, chronic compressive changes and epineural fibrosis of radial nerve were visualized. After a microsurgical neurolysis performed, the complete recovery in the nerve function was obtained in all the cases during the follow-up.Conclusion The findings from this study suggest that every case of type III Monteggia fracture-dislocation with decreased or absent function of muscles innervated by the PIN and an irreducible radial head in child should be viewed as an indication for immediate surgical exploration of the involved nerve to exclude a potential PIN entrapment. | |||
TO cite this article:Li Hai. Posterior interosseous nerve entrapment after Monteggia fracture-dislocation in children[OL].[22 January 2013] http://en.paper.edu.cn/en_releasepaper/content/4516904 |
10. Discovery and identification of serum biomarkers of wilms tumor using proteomics technology | |||
JIA Zhankui,WANG Jiaxiang,YANG Jinjian,XUE Rui,ZHANG Da,WANG Guannan,MA Shengli,DUAN Zhenfeng | |||
Clinical Medicine 13 March 2012 | |||
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Abstract:Background: Wilms tumor (WT, nephroblastoma) is a cancer of the kidneys that typically occurs in children, rarely in adults. Early diagnosis of the disease is very important for its treatment and prognosis, and the aim of our study is to discover and identify potential noninvasive and convenient biomarkers for the diagnosis of this tumor. Methods: Nude mice were used to construct WT model by injecting nephroblastoma cells in their bilateral abdomen. We collected ninety four(94) serum samples from the mice for our study, including 45 WT and 49 controls. Serum proteomic profiles were analyzed using SELDI-TOF-MS. Candidate biomarkers were purified by HPLC, identified by LC-MS/MS and validated using ProteinChip immunoassays. Results: We finally retrieved two differential proteins (m/z 4509.2, 6207.9), which were identified as apolipoprotein A-II and polyubiquitin respectively. Expression of apolipoprotein A-II was higher in the WT group compared with the control group (P<0.01). In contrast, the expression of polyubiquitin was lower in the WT than in the control group. Conclusion: Apolipoprotein A-II and polyubiquitin may be used as potential biomarkers for nephroblastoma in children, and analysis of them may help us in diagnosing and treating this tumor. | |||
TO cite this article:JIA Zhankui,WANG Jiaxiang,YANG Jinjian, et al. Discovery and identification of serum biomarkers of wilms tumor using proteomics technology[OL].[13 March 2012] http://en.paper.edu.cn/en_releasepaper/content/4470377 |
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