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There are 12 papers published in subject: > since this site started. |
Results per page: | 12 Total, 2 Pages | << First < Previous 1 2 |
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1. Establishing a Standard Animal Model of Traumatic Optic Neuropathy with FPI | |||
Yu Jinguo,Yu Rongguo,Shen Zhansheng,Wang Xing,Zhang Wei,Lu Yingjuan,Yan Hua | |||
Clinical Medicine 26 February 2013 | |||
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Abstract:Objective: To establish an animal model of traumatic optic neuropathy (TON) using fluid percussion injury (FPI) that resembles the clinical state with or without lens injury, and observe the different progress of repair using flash visual evoked potential (F-VEP). Methods: Chinese white rabbits were used as the animal research subjects. Sixty-four healthy Chinese white rabbits (128 eyes) were divided into two groups according to right and left eyes. The right eyes were selected as the experimental group (optic nerve injury and lens injury) and the left eyes were used as the control group (optic nerve injury). The traumatic optic neuropathy was made in both eyes using FPI, meanwhile penetrating lens injury was performed by acupuncture needle. According to different observing times, every group was divided into 8 sub-groups. The function of optic nerve was evaluated using F-VEP, and the results were compared between groups and observing times. Results: At one day post injury, the latencies of P100 in both groups were longer, and the amplitudes of P100 in both group were lower than before injury (P<0.05). The duration of longer latency in experimental group was shorter than in the control group (P<0.05). The latency in experimental group restored more quickly than the control group. Conclusions:This animal model is made with high success rate. Macrophage accumulates in retina and optic tissue because of lens injury. There is a good correlation between F-VEP and pathophysiology. | |||
TO cite this article:Yu Jinguo,Yu Rongguo,Shen Zhansheng, et al. Establishing a Standard Animal Model of Traumatic Optic Neuropathy with FPI[OL].[26 February 2013] http://en.paper.edu.cn/en_releasepaper/content/4523593 |
2. Cataract Surgery in Keratoconic Eyes with High Myopia | |||
Sun Chuanbin,Yao Ke | |||
Clinical Medicine 05 March 2012 | |||
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Abstract:Objective: To evaluate the safety, efficacy of cataract surgery, and the predictability of intraocular lens (IOL) power calculation in eyes with mild to moderate keratoconus and high myopia. METHODS: 5 eyes with mild to moderate keratoconus and high myopia underwent phacoemulsification with IOL implantation. Pre- and postoperative evaluation included best corrected visual acuity (BCVA), corneal topography, corneal endothelial cell density, slit-lamp examination, and fundoscopy. The IOL power was calculated by using topographic keratometry in SRK/T fomula. Predictability was measured as aquired spherical equivalent (SE) versus desired refraction (DR) and as the percentage of eyes within ±1.0 D, ± 2.0 D, and ± 3.0 D of defocus equivalent (DE). RESULTS: The mean axial lenth was 31.18 ± 3.08 mm; mean follow-up time was 12.2 ± 5.0 months. All eyes got improved BCVA postoperatively. At the last follow-up, postoperative mean SE was–1.16 ± 0.68 D, while DR was –3.48 ± 1.98 D; the difference between SE and DR was statistically significant (P = 0.036); 3 eyes (60%) were within ±3 D of DE, 1 eye (20%) was within ±2 D, and no eyes were within ±1D. Pre- and postoperative mean keratometric cylinder was – 4.25 ± 1.01 D and –3.58 ± 1.69 D respectively, the difference was not statistically significant (P = 0.346). Corneal endothelial cell loss was 5.3% during follow-up. CONCLUSIONS: Cataract surgery is safe and effective in eyes with mild to moderate keratoconus and high myopia, while the predictability of IOL power calculation needs improvement. | |||
TO cite this article:Sun Chuanbin,Yao Ke. Cataract Surgery in Keratoconic Eyes with High Myopia[OL].[ 5 March 2012] http://en.paper.edu.cn/en_releasepaper/content/4469664 |
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