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| There are 37 papers published in subject: since this site started. | |||
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| 1. Association of estrogen receptor alpha polymorphisms with severity and symptoms of autism spectrum disorders among Chinese Han children | |||
| WANG Xuelai,LIANG Shuang,Takashi X. Fujisawa,Shota Nishitani,Akemi Tomoda,ZOU Mingyang,LI Yang,WU Lijie,Kazuyuki Shinohara | |||
Preventive Medicine and Hygienics 30 September 2014
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| Abstract:Purpose: Autism spectrum disorders (ASD) are a group of neurodevelopment conditions with significant sex differences. Previous studies supported that fetal testosterone exposures might be a strong factor of ASD. As aromatization of testosterone, estrogens play a crucially important role in early nervous system development and sex differentiation through estrogen receptors in animal brain. Several reports have described that single nucleotide polymorphisms (SNPs) of estrogen receptor alpha (ESR1) are associated with psychiatric disorders such as depression and schizophrenia. However, the investigation of ESR1 effected in autism has been neglected. Therefore, we tested the hypothesis that ESR1 gene is involved in the pathogenesis of autism and clinical symptoms. Methods: Genotypes rs11155819 and rs2234693 were determined in 117 children with classic autism and 117 normal children from Chinese Han population. A case-control study was performed to explore the association between ESR1 gene variants and autism susceptibility. The Children Autism Rating Scale (CARS) and Neuropsychological development examination table for children aged 0-6 years old were used, respectively, to evaluate autism severity and the developmental level. Finally, we analyzed the association of these SNPs with specific clinical symptoms. Results: The distribution of genotypes and allele frequencies of rs11155819 and rs2234693 showed no significant differences between classic autism cases and normal healthy controls. However, individuals with rs11155819 T/T genotype showed a higher CARS score, a lower value for fine motor and adaptation ability in development quotient (DQ) (p = 0.033; p = 0.032; p = 0.045). Individuals with rs2234693 T/T genotype had lower values for social behavior in DQ (p = 0.012). Conclusion: Results suggest that ESR1 variants are relevant to autism severity and clinical symptoms in the Chinese Han population. | |||
| TO cite this article:WANG Xuelai,LIANG Shuang,Takashi X. Fujisawa, et al. Association of estrogen receptor alpha polymorphisms with severity and symptoms of autism spectrum disorders among Chinese Han children[OL].[30 September 2014] http://en.paper.edu.cn/en_releasepaper/content/4611980 | |||
| 2. The Association between Forced Sexual Intercourse and Health Risk Behaviours among Chinese Urban High School Students | |||
| SONG Yi,JI Chengye | |||
Preventive Medicine and Hygienics 02 May 2013
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| Abstract:Objective: To determine the association between Health Risk behaviours and a history of forced sexual intercourse among Chinese urban high school students. Methods: A cross-sectional study was performed among 109,754 high school students who participated in 2005 Chinese Youth Risk Behaviour Survey. Data were analyzed for 5215 students who had experienced sex behaviour (1,483 girls, 3732 boys). Multivariate logistic regression was used to determine the demographic variables and all independent relationships. Results: Of students who had sexual intercourse, 40.9% females and 29.6% males experienced forced sex (p<0.01). When analyses controlled for demographic characteristics, for the overall sample, suicidal attempt (OR, 2.3), physical abuse (OR, 1.7), verbal abuse (OR, 1.3), more frequent use of cigarette (OR, 0.5), seldom use of cigarette (OR, 0.7), heavy use of alcohol (OR, 1.6), getting drunk (OR, 0.7), and drug use (OR, 2.4) were correlated with a history of forced sex. It also found that patterns of risk behaviours differed among female and male students who had ever experienced forced sexual intercourse. Conclusions: These results suggest forced sex is associated with many health risk behaviours and approaches to reduce the harms associated with forced sex among students in school are needed. | |||
| TO cite this article:SONG Yi,JI Chengye. The Association between Forced Sexual Intercourse and Health Risk Behaviours among Chinese Urban High School Students[OL].[ 2 May 2013] http://en.paper.edu.cn/en_releasepaper/content/4541083 | |||
| 3. A functional variant in MTRR intron-1 significantly increases risk of congenital heart disease in Han Chinese population | |||
| ZHAO Jianyuan,YANG Xueyan,GU Zhuoya,WANG Jue,DUAN Wenyuan,YE Zhizhou,SHEN Hongbing,SHI Kaihu,HOU Jia,HUANG Guoying,JIN Li,QIAO Bing,WANG Hongyan | |||
| Preventive Medicine and Hygienics 14 January 2013 | |||
| Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
| Abstract:Homocysteine is known to be an independent risk factor for congenital heart disease (CHD). Methionine synthase reductase (MTRR) is essential for adequate remethylation of homocysteine, which is the exclusively dominant pathway for homocysteine removal in earlier embryo development. Here we report the variant c.56+781 A>C (rs326119) in the intron-1 of MTRR significantly increases the CHD risk in Han Chinese population. In three independent case-control studies with a total of 2,340 CHD patients and 2,270 healthy control participants from different geographic areas, we observed that children carrying heterozygote AC and homozygote CC genotype have 1.40 fold (OR=1.40, 95% CI=1.23-1.59, P=2.32×10-7) and 1.84 fold (OR=1.84, 95% CI=1.54-2.20, P=2.3×10-11) increased risk for CHD than those carrying wild-type AA genotype, respectively. Both in vivo quantitative real-time PCR analysis of MTRR mRNA in cardiac tissue samples of CHD and in vitro luciferase assay in transfected cells showed that the c.56+781 C allele remarkably deceases MTRR transcription. Additionally, healthy individuals with homozygous CC genotype have significantly elevated plasma homocysteine level compared with the wild-type AA carriers. Thus, we demonstrated that MTRR c.56+781 A>C variant is an important genetic marker for the increased CHD risk through its down-regulation function on MTRR expression in the transcription stage. Our results accentuate the significance of functional SNP in non-coding region of homocysteine/folate metabolism pathway core genes for their potential contribution to the etiology of CHD. | |||
| TO cite this article:ZHAO Jianyuan,YANG Xueyan,GU Zhuoya, et al. A functional variant in MTRR intron-1 significantly increases risk of congenital heart disease in Han Chinese population[J]. | |||
| 4. A Functional Variant in the Cystathionine b-Synthase Gene Promoter Significantly Reduces Congenital Heart Disease Susceptibility in a Han Chinese Population | |||
| ZHAO Jianyuan,YANG Xueyan,SHI Kaihu,SUN Shuna,HOU Jia,WANG Jue,YE Zhizhou,DUAN Wenyuan,CHEN Yijiang,SHEN Hongbing,QIAO Bin,HUANG Guoying,JIN Li,WANG Hongyan | |||
| Preventive Medicine and Hygienics 10 January 2013 | |||
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| Abstract:Homocysteine is an independent risk factor for various cardiovascular diseases. There are two ways to remove homocysteine from embryonic cardiac cells: remethylation to form methionine or transsulfuration to form cysteine. Cystathionine β-synthase (CBS) catalyzes the first step of homocysteine transsulfuration as a rate-limiting enzyme. In this study, we identified a functional variant -4673C>G (rs2850144) in the CBS gene promoter region that significantly reduces the susceptibility to congenital heart disease (CHD) in a Han Chinese population consisting of 2,340 CHD patients and 2,270 controls. Individuals carrying the heterozygous CG and homozygous GG genotype had a 15% (OR=0.85, 95%CI=0.75-0.96, P=0.011) and 40% (OR=0.60, 95% CI=0.49-0.73, P=1.78×10-7) reduced risk to develop CHD than the wild-type CC genotype carriers in the combined samples, respectively. Additional stratified analyses demonstrated that CBS -4673C>G is significantly related to septation defects and conotruncal defects. In vivo detection of CBS mRNA levels in human cardiac tissues and in vitro luciferase assays consistently showed that the minor G allele significantly increased CBS transcription. A functional analysis revealed that both the attenuated transcription suppressor SP1 binding affinity and the CBS promoter hypomethylation specifically linked with the minor G allele contributed to the remarkably up-regulated CBS expression. Consequently, the carriers with genetically increased CBS expression would benefit from the protection due to the low homocysteine levels maintained by CBS in certain cells during the critical heart development stages. These results shed light on unexpected role of CBS and highlight the importance of homocysteine removal in cardiac development. | |||
| TO cite this article:ZHAO Jianyuan,YANG Xueyan,SHI Kaihu, et al. A Functional Variant in the Cystathionine b-Synthase Gene Promoter Significantly Reduces Congenital Heart Disease Susceptibility in a Han Chinese Population[OL].[10 January 2013] http://en.paper.edu.cn/en_releasepaper/content/4512567 | |||
| 5. The serum pepsinogen II level is a better diagnostic marker in gastric cancer: a cross-sectional study in the Chinese population | |||
| CAO Xueyuan,JIA Zhifang,JIN Meishan,JIANG Jing | |||
| Preventive Medicine and Hygienics 19 December 2012 | |||
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| Abstract:AIM: To investigate screening makers for gastric cancer, we assessed association between gastric cancer with serum pepsinogens in the study.( 19 words) METHODS: From 2008 to 2010, the subjects comprised of 450 patients with gastric cancer, 111 individuals with gastric atrophy, and 961 healthy controls were investigated in a cross section study in the Chinese population. Serum anti-Helicobacter pylori (H.pylori) IgG, pepsinogen (PG)I and PG II were detected by enzyme-linked immunosorbent assay methods (Biohit ELISA kit, Biohit, Helsinki, Finland). Gastric atrophy and gastric cancer were diagnosed by endoscopy and histopatholgical examinations. Odds ratio (ORs) and 95% confidence intervals (CIs) were calculated using a multivariate logistic regression. (82 words) RESULTS: Prevalence rate of H.pylori infection remains high in the Northeastern area of China. Rates of H.pylori IgG positive were greater in the gastric cancer and gastric atrophy groups compared to the control group (69.1%, 75.7% vs 49.7%, P<0.001). Higher level of PG II (15.9, 13.9 vs 11.5, P <0.001) and lower PGI /PGII ratio (5.4, 4.6 vs 8.4, P<0.001) were found in patients with either gastric cancer or gastric atrophy compared to healthy controls, whereas no correlation was found between the plasma PGI concentration and risk of gastric cancer (P=0.537). In addition, multivariate logistic analysis indicates that H.pylori infection and atrophic gastritis were independent risk factors for gastric cancer. Lower plasma PG I: II ratio is associated with higher risks of atrophy and gastric cancer. Furthermore, plasma PG II level significantly correlated with H. pylori-infected gastric cancer. (137 words) CONCLUSION: The serum PG II concentration and PGI/PGII ratio are potential biomarkers for H.pylori-infected gastric disease screening. PG II is independently associated with risk of gastric cancer. | |||
| TO cite this article:CAO Xueyuan,JIA Zhifang,JIN Meishan, et al. The serum pepsinogen II level is a better diagnostic marker in gastric cancer: a cross-sectional study in the Chinese population[OL].[19 December 2012] http://en.paper.edu.cn/en_releasepaper/content/4505640 | |||
| 6. Factors Influencing the Association between CYP17 T34C Polymorphism and the Risk of Breast Cancer: Meta-regression and Subgroup Analysis | |||
| Chen Yun,Pei Jianpin | |||
| Preventive Medicine and Hygienics 17 December 2012
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| Abstract:A number of studies have investigated the association between CYP17 T34C polymorphism and the risk of breast cancer; the results of these studies are inconsistent, however. This fact implies that the effect of CYP17 T34C polymorphism on susceptibility to breast cancer may be modified by other risk factors. To provide a more definitive conclusion, a full meta-analysis combining and summarizing 24 studies was first performed. Both traditional method and Bayesian approach were applied. Odds ratio was estimated using a dominant mode of inheritance after a biological justification for the choice of genetic model. The results of homogeneity analysis (H = 1.16, I2 = 25.4% and p = 0.127) suggested the presence of heterogeneity across the studies. Thus random effects models simulated by the DerSimonian-Laird method were employed. The capability of a Bayesian approach was highlighted in the estimation of a pooled odds ratio and 95% confidence interval. The results of meta-analysis (OR =1.001, CI=0.832-1.208) suggest no significant association in the combined populations. Furthermore, Bayesian meta-regression and subgroup analysis were conducted to investigate the sources of heterogeneity. The risk factors evaluated in the study were menopausal status, ethnicity, age at menarche, age at first birth, parity, use of oral contraceptives, body mass index (BMI) and use of hormone repair therapy (HRT). After these population stratifications, there was evidence indicating a possible impact of menopausal status, age at menarche and BMI on the association between CYP17 T34C polymorphism and the risk of breast cancer. | |||
| TO cite this article:Chen Yun,Pei Jianpin. Factors Influencing the Association between CYP17 T34C Polymorphism and the Risk of Breast Cancer: Meta-regression and Subgroup Analysis[OL].[17 December 2012] http://en.paper.edu.cn/en_releasepaper/content/4500293 | |||
| 7. Effect of Monobutyl phthalate on the expression of GPR30 gene in Sertoli cells | |||
| HU Yang,LU Yuqiu,LI Dongmei,HAN Xiaodong | |||
| Preventive Medicine and Hygienics 26 December 2011
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| Abstract:Recent studies indicated that the rapid and nongenomic action of xenoestrogen may be mediated through the membrane estrogen receptor-G protein-coupled receptor (GPR30). In this study we aimed to explore whether GPR30 is expressed in rat testicular Sertoli cells and the possible effect of monobutyl phthalate (MBP) on the expression of GPR30 in Sertoli cells. By using Rt-PCR, Western-Blot and immunocytochemistry, we assessed the expression of GPR30 in both gene and protein level. Then we examined the change of gene level of GPR30 in Sertoli cells exposed to MBP (0.01-1mM) for24h. The results indicated that GPR30 was expressed in rat testicular Sertoli cells and increased in gene level in Sertoli cells following administration with MBP even at a relative low concentration. We suppose that change of GPR30 expression may play an important role in effect of xenoestrogen MBP on Sertoli cells. | |||
| TO cite this article:HU Yang,LU Yuqiu,LI Dongmei, et al. Effect of Monobutyl phthalate on the expression of GPR30 gene in Sertoli cells[OL].[26 December 2011] http://en.paper.edu.cn/en_releasepaper/content/4457665 | |||
| 8. Potential role of IL-9 in the pathogenesis of systemic lupus erythematosus | |||
| Leng Ruixue,Pan Haifeng,Tao Jinhui,Ye Dongqing | |||
| Preventive Medicine and Hygienics 18 February 2011
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| Abstract:It has been identified that Th cells and their cytokines play a pleiotropic role in the pathogenesis of systemic lupus erythematosus (SLE). Recently, a new effector T cell subset, Th9 cells, which preferentially secrete IL-9, has been identified. Apart from Th9, there is evidence that IL-9 can be produced by several other T cell subsets like Th17. At the same time, IL-9 affecting function of Th cells and mast cell. However, there are no unambiguous conclusions that IL-9 make a contribution for phenotype of SLE. Recently, IL-9 exerts profound anti-inflammatory effects in several cells or experimental autoimmune models. In particular, IL-9 production seems important in mast cell recruitment, defect IL-9/IL-9R axis exhibit a more severe course of EAE and have a defect in the suppressive activity of Tregs, which are implicated a potect role for SLE. In contrast, IL-9 may contribute the proliferation of several CD4+ T cells, suggesting that IL-9 may be therapeutically relevant in SLE. In this article, we briefly discuss the biological features of IL-9 and summarize recent advances focus on the role of IL-9 in the pathogenesis and treatment of SLE. | |||
| TO cite this article:Leng Ruixue,Pan Haifeng,Tao Jinhui, et al. Potential role of IL-9 in the pathogenesis of systemic lupus erythematosus[OL].[18 February 2011] http://en.paper.edu.cn/en_releasepaper/content/4410755 | |||
| 9. Aberrant mRNA and serum expression of TWEAK in patients with systemic lupus erythematosus | |||
| Wang Chao,Chen Lili,Pan Haifeng,Leng Ruixue,Qin Weizi,Ye Dongqing | |||
| Preventive Medicine and Hygienics 18 February 2011
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| Abstract:The aim of this study was to compare the mRNA and serum expression of Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) in patients with systemic lupus erythematosus (SLE) and healthy controls. 62 patients and 15 healthy controls were recruited in the study. TWEAK messenger RNA (mRNA) expression in PBMC from 33 of 62 patients was detected by relative quantitation RT-PCR. TWEAK concentrations in serum of all 62 patients were measured by ELISA. TWEAK mRNA expressions in PBMC were decreased in SLE patients compared with healthy controls. Lower TWEAK mRNA expression was also found in the active SLE patients when compared to inactive counterparties. However, there is no significant difference between LN patients and non-LN SLE patients. The serum level of TWEAK (sTWEAK) in SLE patients was increased when compared to healthy controls. In addition, the sTWEAK level was higher in SLE patients with vasculitis than that in SLE patients without vasculitis, the same was true in comparison between patients with and without headache. Nevertheless, no significant differences were found between active SLE patients and inactive patients, as well as between LN patients and non-LN SLE patients. In our study, SLE patients express reduced TWEAK mRNA but elevated level of sTWEAK, in addition, sTWEAK level was associated with several clinical manifestations of SLE, indicating that TWEAK may play a complex role in SLE. | |||
| TO cite this article:Wang Chao,Chen Lili,Pan Haifeng, et al. Aberrant mRNA and serum expression of TWEAK in patients with systemic lupus erythematosus[OL].[18 February 2011] http://en.paper.edu.cn/en_releasepaper/content/4410696 | |||
| 10. Effect of habitat fragmentation on survival and reproducibility of schistosome-transmitting snail Oncomelania hupensis in Anhui province, China | |||
| Zhou Yibiao,Chen Gengxin,Han Shimin ,He Zonggui,Li Yuanpei,Zhang Zhijie,Wei Jianguo,Zhao Genming ,Jiang Qingwu | |||
| Preventive Medicine and Hygienics 19 January 2011 | |||
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| Abstract:Oncomelania hupensis is of great medical importance as the sole intermediate host of human blood fluke Schistosoma japonicum. Snail habitats in China are becoming increasingly fragmentation as a result of intensive environmental management. Two administrative villages, Anhui province, China were selected to assess the effects of habitat fragmentation on snail survival and reproducibility of snails. The snail habitats of Cao village were fragmented in 2002, and then the fragmentation degree of this village is higher that of Tangxi village. The proportion of qudrats with live snails in Cao village decreased from 87.7% in 2001 to 24.7% in 2010, and reducing by 71.8%, while the proportion of qudrats with live snails in Tangxi village increased from 16.8% in 2002 to 31.7% in 2010, and increased by 88.7%. The mean snail density of Cao village decreased from 5.60 snails / 0.11m2 in 2001 to 0.95 snails / 0.11 m2 in 2010, and reduced by 83.0%, while the mean snail densities of Tangxi village increased from 0.63 snails / 0.11m2 in 2001 to 2.85 snails / 0.11m2 in 2010. The mortality of snails in Cao village was always higher than that in Tangxi village, and the mean live egg density of snails in Cao village was always less than that in Tangxi village in 2009 and 2010. The snail habitats in the study area have exhibited visible fragmentation. Habitat fragmentation could reduce the snail population size and increase the mortality of snails. | |||
| TO cite this article:Zhou Yibiao,Chen Gengxin,Han Shimin , et al. Effect of habitat fragmentation on survival and reproducibility of schistosome-transmitting snail Oncomelania hupensis in Anhui province, China[OL].[19 January 2011] http://en.paper.edu.cn/en_releasepaper/content/4407821 | |||
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