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	1. Accurate Simulations and Analysis of Xinfadi COVID-19 Epidemics in Beijing
	Min Lequan
	Preventive Medicine and Hygienics 19 December 2020
	Show/Hide Abstract \| Cite this paper︱Full-text: PDF (0 B)

	Abstract: To date, more than 71 millions on infected with COVID-19 have been identified worldwide. It causes more 1.6 millions deaths and affects more than 200 countries and regions. Establishing a mathematical model for epidemic infectious diseases has played an important role in the formulation, evaluation, and prevention of control strategies. The event of Xinfadi COVID-19 epidemic provides a successful example for prevent and control strategies and clinical treatments. This paper introduces a symptomatic-asymptomatic-recoverer differential equation model (SARDE). It gives the conditions of the stability on the disease-free equilibrium of SARDE. It proposes the necessary conditions of disease spreading. It determines the parameters of SARDE based on the reported data of Xinfadi COVID-19 epidemic and simulations. Numerical simulations of SARDE describe well the outcomes of current symptomatic individuals, current asymptomatic but infected individuals, recovered symptomatic infected individuals, and recovered asymptomatic but infected individuals. The numerical simulations suggest that both symptomatic and asymptomatic individuals cause lesser asymptomatic spread than symptomatic spread; blocking rate of 97% cannot prevent the spread of Xinfadi COVID19 epidemic; the strict prevention and control strategies implemented by Beijing government are not only very effective but also completely necessary. It is expected that the research results can provide new theoretical tools and ideas worthy of reference for better understanding and dominating of epidemic spreads, preventions and controls.
	TO cite this article:Min Lequan. Accurate Simulations and Analysis of Xinfadi COVID-19 Epidemics in Beijing[OL].[19 December 2020] http://en.paper.edu.cn/en_releasepaper/content/4753222


	2. 1α,25(OH)2D3 regulates the expression profile of lncRNAs in the ovarian cancer cell line SKOV-3
	XUE Yaqi,YE Mengxuan,WANG Songzhi,PEI Hailong,HU Wentao,JIANG Fei,ZHOU Guangming,LI Bingyan
	Preventive Medicine and Hygienics 10 February 2020
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	Abstract:Long non-coding RNAs (lncRNAs) have been reported to be involved in processes of tumor progression. 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3), the active form of vitamin D, has an anti-proliferative effect on tumor cells. Therefore, differentially expressed lncRNAs regulated by 1α,25(OH)2D3 may be associated with tumor progress. This study was aimed to investigate the lncRNAs profiling pattern regulated by 1α,25(OH)2D3 in ovarian cancer cell line SKOV-3 using microarray analysis. After 72 hours of 1α,25(OH)2D3 treatment, 139 lncRNAs and 105 mRNAs were significantly dysregulated. Five lncRNAs were validated by quantitative reverse transcription polymerase chain reaction (qRT-PCR). In functional analysis, dysregulated lncRNAs can participate in biological processes related to systemic lupus erythematosus, alcoholism, osteoclast differentiation and cancer signaling pathways, such as Wnt, TNF and TGF-β receptor signaling. The dysregulated lncRNAs were associated with their co-expressed genes and may be mainly regulated by these three transcription factors, TAF7, POU2F2 and KAT2A. Additionally, there were 17 lncRNAs co-expressed with genes VDR, CYP24A1 and CDH1, suggesting that these lncRNAs acted as the connection to associate vitamin D signaling with EMT. These data constitute the first report of lncRNA expression patterns regulated by 1α,25(OH)2D3 in human ovarian cancer cells, and will provide new evidence for the anti-tumor effect of 1α,25(OH)2D3 through lncRNAs.
	TO cite this article:XUE Yaqi,YE Mengxuan,WANG Songzhi, et al. 1α,25(OH)2D3 regulates the expression profile of lncRNAs in the ovarian cancer cell line SKOV-3[OL].[10 February 2020] http://en.paper.edu.cn/en_releasepaper/content/4750682


	3. Association of estrogen receptor alpha polymorphisms with severity and symptoms of autism spectrum disorders among Chinese Han children
	WANG Xuelai,LIANG Shuang,Takashi X. Fujisawa,Shota Nishitani,Akemi Tomoda,ZOU Mingyang,LI Yang,WU Lijie,Kazuyuki Shinohara
	Preventive Medicine and Hygienics 30 September 2014
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	Abstract:Purpose: Autism spectrum disorders (ASD) are a group of neurodevelopment conditions with significant sex differences. Previous studies supported that fetal testosterone exposures might be a strong factor of ASD. As aromatization of testosterone, estrogens play a crucially important role in early nervous system development and sex differentiation through estrogen receptors in animal brain. Several reports have described that single nucleotide polymorphisms (SNPs) of estrogen receptor alpha (ESR1) are associated with psychiatric disorders such as depression and schizophrenia. However, the investigation of ESR1 effected in autism has been neglected. Therefore, we tested the hypothesis that ESR1 gene is involved in the pathogenesis of autism and clinical symptoms. Methods: Genotypes rs11155819 and rs2234693 were determined in 117 children with classic autism and 117 normal children from Chinese Han population. A case-control study was performed to explore the association between ESR1 gene variants and autism susceptibility. The Children Autism Rating Scale (CARS) and Neuropsychological development examination table for children aged 0-6 years old were used, respectively, to evaluate autism severity and the developmental level. Finally, we analyzed the association of these SNPs with specific clinical symptoms. Results: The distribution of genotypes and allele frequencies of rs11155819 and rs2234693 showed no significant differences between classic autism cases and normal healthy controls. However, individuals with rs11155819 T/T genotype showed a higher CARS score, a lower value for fine motor and adaptation ability in development quotient (DQ) (p = 0.033; p = 0.032; p = 0.045). Individuals with rs2234693 T/T genotype had lower values for social behavior in DQ (p = 0.012). Conclusion: Results suggest that ESR1 variants are relevant to autism severity and clinical symptoms in the Chinese Han population.
	TO cite this article:WANG Xuelai,LIANG Shuang,Takashi X. Fujisawa, et al. Association of estrogen receptor alpha polymorphisms with severity and symptoms of autism spectrum disorders among Chinese Han children[OL].[30 September 2014] http://en.paper.edu.cn/en_releasepaper/content/4611980

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