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There are 93 papers published in subject: since this site started. |
Results per page: | 93 Total, 10 Pages | << First < Previous 7 8 9 10 |
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1. Synthesis and NO Scavenging Activity of 2-Substitute-nitronyl Nitroxides | |||
Zheng Li,Ming Zhao,Chao Wang | |||
Pharmacy 18 January 2005 | |||
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Abstract:2-Alkyl-, 2-heterocyclic and 2-phenyl-nitronyl nitroxides were prepared. Their free radical property was confirmed by ESR spectra. The in vitro NO scavenging activity was evaluated by the aortic strip experiments. Among the investigation of three kinds of structural nitronyl nitroxides, the 2-phenylsubstituted nitronyl nitroxides are chemically stable and biologically potent. | |||
TO cite this article:Zheng Li,Ming Zhao,Chao Wang. Synthesis and NO Scavenging Activity of 2-Substitute-nitronyl Nitroxides[OL].[18 January 2005] http://en.paper.edu.cn/en_releasepaper/content/1472 |
2. In vitro and in vivo stabilities of doxorubicin aggregates with various salts inside liposomes | |||
Zhang,Lei,Pan,Hong,Liu,Min | |||
Pharmacy 05 January 2005 | |||
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Abstract:iposomes containing different doxorubicin (DOX)-salt aggregates were prepared and the influence of aggregates on the stability of liposomal DOX in vitro and in vivo was investigated. Liposomes were prepared by the film method and hydrated with various buffer, such as, glycine buffer, citric buffer or ammonium sulfate solution. Then DOX was loaded into the liposomes via transmembrane gradient method. Characterizations of liposome were studied and DOX loading efficiency was determined spectrophotometrically. The binding constants (K) of the DOX-salt aggregates were calculated. In vitro leakage of doxorubicin from different aggregates inside liposomes was studied. When liposomal DOX was administered into rats at a dose of 5 mg/kg intravenously, the concentrations of DOX in blood were measured at different time after injection. Results showed the order of the K value of the aggregates was DOX-sulfate aggregates > DOX-citric aggregates > DOX-glycine aggregates. Transmission electron photom | |||
TO cite this article:Zhang,Lei,Pan,Hong,Liu,Min. In vitro and in vivo stabilities of doxorubicin aggregates with various salts inside liposomes[OL].[ 5 January 2005] http://en.paper.edu.cn/en_releasepaper/content/1419 |
3. Design, synthesis and 3D-QSAR evaluation of pyrrolidine derivatives as MMP-2,9 Inhibitors | |||
Wenfang Xu,Wengang Yin,Yalin Li | |||
Pharmacy 06 December 2004 | |||
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Abstract:igand interacting with matrix metalloproteinase (MMP) in catalytic domain was understood by investigating the crystallogram of catalytic domain of MMP-2 complexed with sc-74020, then mimicing these interactions, using 4-hydroxyproline as the basic scaffold to improve selectivity of MMPIs targeted MMP-2 with considering that 4-hydroxyproline is the special amino acid existing in collagen which is the natural substrate for the collagenase. Two series of 43 novel 4-hydroxyproline derivatives as a human collagenase type Ⅳ (MMP-2 and MMP-9) inhibitors were designed, synthesized, and investigated by 3D-QSAR(CoMFA). All tested compounds were orally administered at a dose of 50 or 100mg/kg, 6 days/week for two weeks. The test results demonstrated that most of these compounds showed significant anti-cancer activities (inhibitory rate > 35%) and were devoid of toxic effects in vitro and in vivo. Compound 47 showed a good inhibiting ability against the gelatinase in vitro and the best anticancer | |||
TO cite this article:Wenfang Xu,Wengang Yin,Yalin Li. Design, synthesis and 3D-QSAR evaluation of pyrrolidine derivatives as MMP-2,9 Inhibitors[OL].[ 6 December 2004] http://en.paper.edu.cn/en_releasepaper/content/1327 |
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