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	1. Extraction and Separation of Deguelin from the Roots of Derris trifoliate Lour and Its HPLC Analysis
	Guan Yongguang,Gan Chunji
	Pharmacy 09 November 2007
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	Abstract:Three methods were applied to extract deguelin from Derris trifoliate roots. Different solvents were used to separate rotenoids, such as deguelin, rotenone and elliptone. The weight of total extract and the relative deguelin extraction efficiency were determined. The total amount of the extracted substance assisted by using ultrasound was lower than the Sohxlet or vibrating extraction method. However, deguelin extraction rate by using the ultrasound-assisted extraction was the highest. Furthermore, with respect of rotenoids separation, the solvent mixture of petroleum ether:chloroform:acetone at the ratio of 6:1:1 was found to be most effective. The maximum optical absorption of deguelin occurred at 271.6 nm. It suggested that the deguelin and rotenone content could be determined at 280 nm.
	TO cite this article:Guan Yongguang,Gan Chunji. Extraction and Separation of Deguelin from the Roots of Derris trifoliate Lour and Its HPLC Analysis[OL].[ 9 November 2007] http://en.paper.edu.cn/en_releasepaper/content/16252


	2. Synthesis of novel ADPR analogues: substitution of pyrophosphate linkage by dipeptide
	Chao Zhang,Zhenjun Yang,Liangren Zhang,Lihe Zhang
	Pharmacy 12 October 2007
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	Abstract:For investigating the biological function of ADPR, four novel analogues (compound 2-5) in which the pyrophosphate linkage was replaced by the aspartic acid dipeptide have been synthesized in this study. 5’-Amino adenosine or its analogues was used as the starting material, liquid phase peptide synthesis strategy was used to construct these ADPR analogues. The structures were characterized by 1H-NMR and HRMS spectra. This study provides a versatile synthsis of peptide modified ADPR analogues and helps to understand the structure-activity relationship of ADPR.
	TO cite this article:Chao Zhang,Zhenjun Yang,Liangren Zhang, et al. Synthesis of novel ADPR analogues: substitution of pyrophosphate linkage by dipeptide[OL].[12 October 2007] http://en.paper.edu.cn/en_releasepaper/content/15635


	3. PLATELET BINDING, ELECTROPHORESIS AND BIOASSAY BASED IDENTIFICATION OF THE BAOACTIVE COMPONENT IN SNAKE VENOM
	Yang Jian,Zhao Ming
	Pharmacy 24 October 2006
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	Abstract:Crude Venom of Agkistrodon halys palls (f0) were separated by use of sepadex-100 column and 6 fractions (f1-6) were obtained. In the bioassay, for instance anti-thrombosis assay, anti-aggregation assay, mice bleeding time test, bovine fibrin plate assay of the main fractions (f1-4), f4 exhibited the highest potency in the anti-thrombosis related experiments and f3 exhibited the highest potency in the thrombolysis related experiments. The results from the fixed platelet binding experiment and the electrophoresis indicated that there were two strips (approximate molecular weight 20000 and 28000) in f4 should be specifically responsible for its excellent anti-thrombosis related activities. The results from the euglobulin clot lysis experiment and the electrophoresis indicated that there were also two strips (approximate molecular weight 48000 and 52000) in f3 should be specifically responsible for its good thrombolysis related activities.
	TO cite this article:Yang Jian,Zhao Ming. PLATELET BINDING, ELECTROPHORESIS AND BIOASSAY BASED IDENTIFICATION OF THE BAOACTIVE COMPONENT IN SNAKE VENOM[OL].[24 October 2006] http://en.paper.edu.cn/en_releasepaper/content/8956


	4. Synthesis and Antitumor Activities of Emodin Derivatives
	Wang Xingpo,Xu Wenfang
	Pharmacy 22 August 2005
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	Abstract:A series of novel Emodin derivatives were designed and synthesized as potential antitumor agents by the regioselective substitution and ring-opening reaction starting from the natural product Emodin. The structures of the compounds were identified by NMR, ESI-MS and elemental analysis. Their antitumor activities against KLE cell line were tested by MTT assay. Some of them were found to exhibit a cytotoxicity profile more potent than Emodin on KLE cell line. The derivatives of Emodin are hope to be promising antitumor agents and it is worthy of being investigated continually.
	TO cite this article:Wang Xingpo,Xu Wenfang. Synthesis and Antitumor Activities of Emodin Derivatives[OL].[22 August 2005] http://en.paper.edu.cn/en_releasepaper/content/2714


	5. Synthesis and NO Scavenging Activity of 2-Substitute-nitronyl Nitroxides
	Zheng Li,Ming Zhao,Chao Wang
	Pharmacy 18 January 2005
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	Abstract:2-Alkyl-, 2-heterocyclic and 2-phenyl-nitronyl nitroxides were prepared. Their free radical property was confirmed by ESR spectra. The in vitro NO scavenging activity was evaluated by the aortic strip experiments. Among the investigation of three kinds of structural nitronyl nitroxides, the 2-phenylsubstituted nitronyl nitroxides are chemically stable and biologically potent.
	TO cite this article:Zheng Li,Ming Zhao,Chao Wang. Synthesis and NO Scavenging Activity of 2-Substitute-nitronyl Nitroxides[OL].[18 January 2005] http://en.paper.edu.cn/en_releasepaper/content/1472

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