Authentication email has already been sent, please check your email box: and activate it as soon as possible.
You can login to My Profile and manage your email alerts.
If you haven’t received the email, please:
|
|
There are 5 papers published in subject: since this site started. |
Results per page: |
Select Subject |
Select/Unselect all | For Selected Papers |
Saved Papers
Please enter a name for this paper to be shown in your personalized Saved Papers list
|
1. Reduning Injection Sensitization in Guinea pigs | |||
Wang Fang,Peng Guoping,Xiao Wei,Wang Zhenzhong,Zheng yunfeng,Li Cunyu,Zhu Huaxu | |||
Traditional Chinese Medicine and Pharmacology 25 July 2014 | |||
Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
Abstract:Reduning injection, a traditional Chinese medicine injection, has multiple functions such as clearing heat, dispelling wind, as well as detoxification. However, there are a few reports of severe anaphylaxis during the clinical application of reduning. The aim of this study is to determine the sensitization to reduning in guinea pigs and the underlying cause of the anaphylactic reaction. The compositions and Tween-80 in reduning were determined before and after ultrafiltration. Egg albumin, ultrafiltered reduning, unfiltered reduning, Tween-80 and nine compositions in reduning were selected to sensitize and stimulate the animals. Changes in the levels of plasma 5-hydroxytryptamine were used to analyze the effect of ultrafiltration on the sensitization effect of reduning injection. We detected a significant decrease in Tween-80 content but a less significant decrease in the other components of the injection following ultrafiltration. Unfiltered reduning injection, Tween-80, and chlorogenic acid caused remarkable sensitization on guinea pigs while the filtered reduning injection resulted in a significantly lower degree of sensitization. These results suggest that ultrafiltration significantly reduced the sensitizing effect of reduning injection, which is likely due to Tween-80 content. Additionally, the form of chlorogenic acid within the complex solution mixture may also affect the sensitizing effect of chlorogenic acid. | |||
TO cite this article:Wang Fang,Peng Guoping,Xiao Wei, et al. Reduning Injection Sensitization in Guinea pigs[OL].[25 July 2014] http://en.paper.edu.cn/en_releasepaper/content/4604851 |
2. Duhuo Jisheng Decoction promotes chondrocyte proliferation through accelerated G1/S transition in osteoarthritis | |||
WU Guangwen,CHEN Wenlie,ZHENG Chunsong,CHU Jianfeng,LIN Ruhui,YE Jinxia,XU Huifeng,LI Xihai,HUANG Yunmei,YE Hongzhi,LIU Xianxiang,WU Mingxia | |||
Traditional Chinese Medicine and Pharmacology 24 June 2013 | |||
Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
Abstract:Objective: To investigate the molecular mechanisms behind the therapeutic effects of Duhuo Jisheng Decoction (DHJSD) on osteoarthritis (OA). Methods: A total of 27 two-month-old male Sprague Dawley rats were randomly divided into three groups: the control group (no papain-induced OA; received an equivalent amount of saline only), the model group (papain-induced OA; received an equivalent amount of saline only) and the DHJSD group [papain-induced OA; received a clinical oral dose of DHJSD (9.3g/kg/day)]. After 8 consecutive weeks of treatment, the morphological changes in articular cartilage were observed under an optical microscopy and by transmission electron microscopy (TEM), and the mRNA and protein expression levels of Cyclin D1, CDK4, CDK6, Rb and p16 were measured by RT-PCR and immunohistochemistry, respectively. Results: Treatment with DHJSD significantly improved the arrangement of articular cartilage structure and collagen fibers and reduced cell degeneration compared with the model group. The mRNA and protein expression levels of Cyclin D1, CDK4, CDK6 and Rb in DHJSD-treated group were significantly increased compared to those in the model group, whereas p16 expression was significantly down-regulated. Conclusion: DHJSD treatment promotes chondrocyte proliferation by promoting the G1/S checkpoint transition in the cell cycle and by up-regulating the expression of Cyclin D1, CDK4, CDK6 and Rb and down-regulating the expression of p16 and this may, in part, explain its clinical efficacy in the treatment of osteoarthritis. | |||
TO cite this article:WU Guangwen,CHEN Wenlie,ZHENG Chunsong, et al. Duhuo Jisheng Decoction promotes chondrocyte proliferation through accelerated G1/S transition in osteoarthritis[OL].[24 June 2013] http://en.paper.edu.cn/en_releasepaper/content/4549063 |
3. squamosa seeds extract containing annonaceous acetogenin compounds | |||
CHEN Yong,XU Shasha,CHEN Jianwei,WANG Yu,XU Huiqing,FAN Naibing,LI Xiang | |||
Traditional Chinese Medicine and Pharmacology 15 May 2012 | |||
Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
Abstract:Seeds of Annona squamosa L. have been used in the south of China as a folk remedy to treat "malignant sores" (cancer). To investigate the chemical constituents and the anti-tumor activity of the standardized A. squamosa seeds extract in vitro and in vivo. Annonaceous acetogenin profiles of the standardized extract were determined by using Fourier transform infrared (FT-IR) and high performance liquid chromatography (HPLC) techniques. The anti-tumor activity of the extract was tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) cytotoxicity in vitro and H22 hepatoma cells transplantation tumor model in vivo. The FT-IR spectroscopy showed the presence of annonaceous acetogenin compounds in the extract. Two major annonaceous acetogenins: 12, 15-cis-squamostatin-A and bullatacin were identified and quantified by HPLC. The seed extract showed significant anti-tumor activity against four human tumor cell lines, especially for MCF-7 (IC50. 0.25 μg/ml) and Hep G2 (IC50. 0.36 μg/ml) cells in vitro. The extract inhibited the growth of H22 tumor cells in mice with a maximum inhibitory rate of 69.55% by oral administration. A. squamosa seed extract showed significant anti-tumor activities against human hepatoma cells in vitro and in vivo, indicating a potential for developing the extract as a novel anti-liver cancer drug. | |||
TO cite this article:CHEN Yong,XU Shasha,CHEN Jianwei, et al. squamosa seeds extract containing annonaceous acetogenin compounds[OL].[15 May 2012] http://en.paper.edu.cn/en_releasepaper/content/4478623 |
4. Monodisperse core-shell microstructured molecular imprinting silica for highly selective enrichment of isoflavonoid glycosides from Radix Puerariae | |||
Jing Luo,Qing Zhang,Liying Zhang,Jiawei Zhao,Shuhu Du | |||
Traditional Chinese Medicine and Pharmacology 20 April 2012 | |||
Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
Abstract:This paper reports the preparation of puerarin (PR) imprinted layer-coated silica microparticles toward selective recognition of PR and fast affinity-enrichment of the main isoflavonoid glycosides from the crude extract of Radix puerariae. Before the preparation, quantum mechanics (QM) method was applied to identify three kinds of common functional monomers capable of interaction with PR and then predict optimal functional monomer (acrylamide, AA) and the relative molar ratio of template to functional monomer (PR/AA, 1 : 4). The obtained PR-imprinted silica microparticles were evaluated by transmission electron microscope (TEM) and rebinding experiments, exhibiting good morphology and high binding affinity to PR. Meanwhile, the rebinding amount of the imprinted microparticles to PR was nearly 2.1-folds that of non-imprinted microparticles. When the PR-imprinted microspheres were used as packing materials for solid-phase extraction, the recovery yields of PR, daidzin (DD) and genistin (GS) were simultaneously up to 90% by one-step extraction from the crude extract of Radix puerariae. Additionally, the PR-imprinted microparticles could be re-used for at least 5 times without losing any extraction efficiency. These results indicate that the PR-imprinted microparticles have highly selective adsorption capabilities to PR, DD and GS from the crude extract of Radix puerariae. The method of molecularly imprinted polymers (MIPs) coupled with solid-phase extraction (SPE) provides a good solution of the enrichment and separation of active extracts from complicated traditional Chinese medicine (TCM) with certain structures. | |||
TO cite this article:Jing Luo,Qing Zhang,Liying Zhang, et al. Monodisperse core-shell microstructured molecular imprinting silica for highly selective enrichment of isoflavonoid glycosides from Radix Puerariae[OL].[20 April 2012] http://en.paper.edu.cn/en_releasepaper/content/4476028 |
5. Traditional Chinese Surgical Treatment “suture dragging combined with pad compression” for anal fistulae with secondary tracks and abscess | |||
Lu Jingen,Wang Chen | |||
Traditional Chinese Medicine and Pharmacology 31 December 2011 | |||
Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
Abstract:Purpose This study aimed to evaluate the efficacy and safety of traditional Chinese surgical treatment "suture dragging combined with pad compression" vs fistulotomy for anal fistulae with secondary tracks and abscess. Methods From January 2008 to March 2009, 60 patients with intersphincteric or transsphincteric anal fistulas with secondary tracks and abscess were randomly divided into study group (suture dragging combined with pad compression, SDPC) and control group (fistulotomy, F). The time of healing, recurrence rate, postoperative pain (VAS), patient satisfaction,incontinence evaluation and anorectal manometry before and after treatment were all examined. Results The time of healing (SDPC 24.33d vs F 31.57d; p<0.01) was significantly shorter and patient satisfaction score (SDPC 4.07 vs F 3.37; p<0.05) was significantly higher in the SDPC group. There were no significant differences between both groups regarding age, gender, fistulae type, mean postoperative pain scores, recurrence rate, incontinence evaluation and anorectal manometry (including maximal anal squeeze pressure and anal resting pressure) before and after treatment. Conclusions Traditional Chinese surgical treatment "suture dragging combined with pad compression" for anal fistulae with secondary tracks and abscess is less invasive, safe and effective. | |||
TO cite this article:Lu Jingen,Wang Chen. Traditional Chinese Surgical Treatment “suture dragging combined with pad compression” for anal fistulae with secondary tracks and abscess[OL].[31 December 2011] http://en.paper.edu.cn/en_releasepaper/content/4458139 |
Select/Unselect all | For Selected Papers |
Saved Papers
Please enter a name for this paper to be shown in your personalized Saved Papers list
|
|
Results per page: |
About Sciencepaper Online | Privacy Policy | Terms & Conditions | Contact Us
© 2003-2012 Sciencepaper Online. unless otherwise stated