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1. Development of a LC-MS/MS Method for Determination of Triptolide in Mouse Plasma: Application to Potential Drug-drug Interaction | |||
ZHANG Junying,LIU Xiaoying,WU Chunyong | |||
Traditional Chinese Medicine and Pharmacology 12 May 2016 | |||
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Abstract:A simple, sensitive, and accurate LC-MS/MS method for determining triptolide in mouse plasma has been developed and validated to study the drug-drug interaction with curcumin. The quantification was performed with the transitions of [M+NH4]+→[M+H]+ for triptolide. The assay for triptolide in mouse plasma was linear over the range of 0.25 to 100 ng/mL and the Lower Limit of Quantification was 0.25 ng/ml. After a single oral administration of triptolide at 0.5 mg/kg, triptolide reached the maximum exposure at 11.64 ± 4.08 min, and declined rapidly with a mean elimination half-life of 38.52 min. Co-administration of 400 mg/kg curcumin significantly increased Cmax and AUC0-∞ by 1.8-fold and 1.5-fold respectively, demonstrating that curcumin increases the bioavailability of triptolide in mouse. | |||
TO cite this article:ZHANG Junying,LIU Xiaoying,WU Chunyong. Development of a LC-MS/MS Method for Determination of Triptolide in Mouse Plasma: Application to Potential Drug-drug Interaction[OL].[12 May 2016] http://en.paper.edu.cn/en_releasepaper/content/4689876 |
2. Preparation, hydrolysis and bioactivity evaluation of a natural polysaccharide from sclerotium of Poria cocos | |||
Chen Qi,Yang Jia,Xu Wenjin | |||
Traditional Chinese Medicine and Pharmacology 08 March 2016 | |||
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Abstract:Pachyman isolated from a natural polysaccharide is lack of bioactivity due to its water-insolubility. In this study, in order to improve its bioactivity, pachyman was enzymatically hydrolyzed to obtain water soluble pachyman (WSP). Moreover, in order to further evaluate the relationship between the structure and bioactivity of pachyman, carboxymethylated pachyman (CMP) with different degree of substitution (DS) and water-soluble pachyman with different molecular weight were also prepared and their antitumor activities against S180 cells were further evaluated. Our results showed that both enzymatic hydrolysis and chemical modification were effective for improving the antitumor activity of pachyman. However, our data also suggested that the molecular weight and the degree of substitution of the derivatives should be taken into account when developing polysaccharide-based drugs. | |||
TO cite this article:Chen Qi,Yang Jia,Xu Wenjin. Preparation, hydrolysis and bioactivity evaluation of a natural polysaccharide from sclerotium of Poria cocos[OL].[ 8 March 2016] http://en.paper.edu.cn/en_releasepaper/content/4679252 |
3. Effects of senkyunolide I on brain and plasma levels of four neurotransmitters in a rat model of migraine | |||
WANG Yihan,MA Qiang,FENG Yi,XU Desheng,WANG Yuan,LIANG Shuang | |||
Traditional Chinese Medicine and Pharmacology 14 January 2016 | |||
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Abstract:Senkyunolide I is one of the major anti-migraine agents from the rhizome of Ligusticum chuanxiong Hort (chuanxiong, Umbelliferae family). Its effects on levels of β-endorphin (β-EP), endothelin-1 (ET-1), calcitonin gene-related peptide (CGRP) and 5-hydroxytryptamine (5-HT) in brain tissue and plasma were evaluated in the nitroglycerin-induced migraine rat model. Oral senkyunolide I returned elevated levels of plasma β-EP, ET-1 and CGRP to approximately those of the control group. The concentration of 5-HT in the plasma of the migraine group decreased after 240 min. In contrast, the 5-HT concentration in the plasma of the senkyunolide I group increased. The present study suggests that senkyunolide I can alter the level of β-EP, ET-1 and CGRP and 5-HT in plasma and brain tissue. This result may help to explain why senkyunolide I can reduce the pain threshold and suggests that it may be a key effective component of L. chuanxiong, which is commonly used to treat migraine. | |||
TO cite this article:WANG Yihan,MA Qiang,FENG Yi, et al. Effects of senkyunolide I on brain and plasma levels of four neurotransmitters in a rat model of migraine[OL].[14 January 2016] http://en.paper.edu.cn/en_releasepaper/content/4676282 |
4. Research progress on Coryrlus heterophylla Fish.Leaf | |||
Jin zhexiong,Zhang yanping | |||
Traditional Chinese Medicine and Pharmacology 23 December 2015 | |||
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Abstract:Coryrlus heterophylla Fish.Leaf studies in the past 20 years were summarized. From CNKI database analysis, summarized 3 research hotspots: chemical composition, extraction and determination,feed development. It has the development and utilization prospects based on literature review in these 3 research hotspots. | |||
TO cite this article:Jin zhexiong,Zhang yanping. Research progress on Coryrlus heterophylla Fish.Leaf[OL].[23 December 2015] http://en.paper.edu.cn/en_releasepaper/content/4673292 |
5. Research on pharmacological effects of lycorine from Amaryllidaceae | |||
ZHANG Xiujuan,YU Miao,JIA Weiling,JI Yubin,ZOU Xiang,GAO Shiyong,XIN Guosong | |||
Traditional Chinese Medicine and Pharmacology 03 December 2015 | |||
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Abstract:This paper described some pharmacological effects of lycorine from Amaryllidaceae plants. Lycorine contains a variety of unique biological activity and the pharmacological activity. New researches showed that they primarily have anti-tumor, anti-inflammatory, anti-bacterial and anti-viral as well as pharmacological activity on the central nervous system. In this paper, the pharmacological of lycorine could provide a reference for the further development and utilization of the plants in family Amarylidacae. | |||
TO cite this article:ZHANG Xiujuan,YU Miao,JIA Weiling, et al. Research on pharmacological effects of lycorine from Amaryllidaceae[OL].[ 3 December 2015] http://en.paper.edu.cn/en_releasepaper/content/4665614 |
6. The Toxic Actions and Pharmacological Activities of Veratramine | |||
LYU Chunming,ZHANG Ning | |||
Traditional Chinese Medicine and Pharmacology 05 November 2015 | |||
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Abstract:The steroidal alkaloid veratramine shows a variety of toxic actions and pharmacological activities. It is believed that veratramine has cardiac activity, antitumor activity and central action. Veratramine has also been recognized as a 5-HT agonist. The mechanisms of these toxic actions and pharmacological activities were investigated. In previous reports, microbial biotransformation of veratramine was carried out with two types of fungi (Nocardia species ATCC 21145 and Cunninghamella echinulata). Rings A and B of veratramine were transformed and seven new metabolites were identified. The toxic actions and pharmacological activities of veratramine, the corresponding mechanisms together with the microbial biotransformation of veratramine are reviewed in this paper. | |||
TO cite this article:LYU Chunming,ZHANG Ning. The Toxic Actions and Pharmacological Activities of Veratramine[OL].[ 5 November 2015] http://en.paper.edu.cn/en_releasepaper/content/4660115 |
7. Marsdenia tenacissima extract enhances gefitinib efficacy in non-small cell lung cancer xenogratfs | |||
Han Shuyan,Zhao Wei,Hong Sun,An Guo,Li Pingping | |||
Traditional Chinese Medicine and Pharmacology 25 December 2014 | |||
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Abstract:The stem of Marsdenia tenacissima (Roxb.) Wight et Arn. has long been used as a medicine to treat cancer in China. Our previous results showed that Marsdenia tenacissima extract (MTE) overcomes gefitinib resistance in NSCLC cells. The present study investigated in vivo anti-tumor activity of MTE combined with gefitinib. H460 (K-ras mutation) or H1975 cells (T790M mutation) was subcutaneously inoculated into nude mice. Tumor volume and body weight were measured during the experiment. The resected tumors were weighed after animals were sacrificed. Cellular proliferation and apoptosis in xenografts tumor tissue were assessed. EGFR downstream pathways and c-Met expression was evaluated by western blotting. In accordance with the previous in vitro study, MTE at low dose (5 g/kg) was chosen to assess whether it can restore gefitinib sensitivity in vivo. Interestingly, MTE prominently enhanced gefitinib efficacy in the resistant H460 and H1975 xenografts. This combination significantly inhibited tumor proliferation and induced cell apoptosis in both resistant NSCLC xenografts. Constitutive activation of PI3K/Akt and MEK/ERK pathway is related to EGFR-TKI resistance. Accordingly, phosphorylation of PI3K/Akt/mTOR and ERK1/2 was suppressed after the combined treatment. Simultaneously, the cross-talked c-Met and EGFR was also prominently lowered in the presence of MTE combined with gefitinib. This study provides in vivo evidence to demonstrate that MTE enhancing gefitinib efficacy in the resistant NSCLC xenografts, and suggests the combination of MTE and gefitinib as a promising approach against NSCLC. | |||
TO cite this article:Han Shuyan,Zhao Wei,Hong Sun, et al. Marsdenia tenacissima extract enhances gefitinib efficacy in non-small cell lung cancer xenogratfs[OL].[25 December 2014] http://en.paper.edu.cn/en_releasepaper/content/4625452 |
8. Reduning Injection Sensitization in Guinea pigs | |||
Wang Fang,Peng Guoping,Xiao Wei,Wang Zhenzhong,Zheng yunfeng,Li Cunyu,Zhu Huaxu | |||
Traditional Chinese Medicine and Pharmacology 25 July 2014 | |||
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Abstract:Reduning injection, a traditional Chinese medicine injection, has multiple functions such as clearing heat, dispelling wind, as well as detoxification. However, there are a few reports of severe anaphylaxis during the clinical application of reduning. The aim of this study is to determine the sensitization to reduning in guinea pigs and the underlying cause of the anaphylactic reaction. The compositions and Tween-80 in reduning were determined before and after ultrafiltration. Egg albumin, ultrafiltered reduning, unfiltered reduning, Tween-80 and nine compositions in reduning were selected to sensitize and stimulate the animals. Changes in the levels of plasma 5-hydroxytryptamine were used to analyze the effect of ultrafiltration on the sensitization effect of reduning injection. We detected a significant decrease in Tween-80 content but a less significant decrease in the other components of the injection following ultrafiltration. Unfiltered reduning injection, Tween-80, and chlorogenic acid caused remarkable sensitization on guinea pigs while the filtered reduning injection resulted in a significantly lower degree of sensitization. These results suggest that ultrafiltration significantly reduced the sensitizing effect of reduning injection, which is likely due to Tween-80 content. Additionally, the form of chlorogenic acid within the complex solution mixture may also affect the sensitizing effect of chlorogenic acid. | |||
TO cite this article:Wang Fang,Peng Guoping,Xiao Wei, et al. Reduning Injection Sensitization in Guinea pigs[OL].[25 July 2014] http://en.paper.edu.cn/en_releasepaper/content/4604851 |
9. Protective effect of total glycoside from Ligustrum lucidum on concanavalin A-induced liver injury in mice | |||
YANG Nianyun,GUO Jianming,YU Li | |||
Traditional Chinese Medicine and Pharmacology 15 January 2014 | |||
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Abstract:Objective: To investigate the protective effect of total glycoside extract (TGE) from Ligustrum lucidum on concanavalin A-induced liver injury in mice. Methods: Con A injection into the tail vein caused hepatitis mice model via an intragastric feeding and TGE was meanwhile intervened, while the mice in control group were fed normal diet. At the end of experiments, all the mice were sacrificed to analyze serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), tumor necrosis factor-a (TNF-a) and interleukin-6 (IL-6) levels. Pathological changes of hepatic tissues were observed under microscope. Results: Compared to model group, serum ALT, AST, TNF-a and IL-6 levels exhibited an obvious reduction in TGE intervened mice (P<0.05). Conclusion: TGE has a significant preventive effect on Con A-induced hepatitis in mice, which can inhibit pro-inflammatory cytokines, relieve the peroxidation injury and improve liver function. | |||
TO cite this article:YANG Nianyun,GUO Jianming,YU Li. Protective effect of total glycoside from Ligustrum lucidum on concanavalin A-induced liver injury in mice[OL].[15 January 2014] http://en.paper.edu.cn/en_releasepaper/content/4582559 |
10. Antiplatelet Profiles of Six Water Extracts from Medicinal Herbs for Activating Blood and Resolving Stasis | |||
TAO Li,ZHANG Lei,RUAN Junshan,YAN Linggeng,LU Yin | |||
Traditional Chinese Medicine and Pharmacology 05 December 2013 | |||
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Abstract:Traditional Chinese medicine (TCM) for activating blood and resolving stasis (Huoxuehuayu) has been widely applied in treatment of various platelet-related diseases. The present study was to explore the antiplatelet activity of the water extracts from six kinds of Huoxuehuayu herbs commonly used in clinical context, which fall into three categories, namely Hexue, Huoxue, and Poxue. We also investigated the differences in the antiplatelet activity of the water extracts from three categories. To this end, human platelet aggregation assay induced by ADP and thrombin was used to evaluate the antiplatelet activity, and flow cytometry assay for detecting the effects on the expression of CD41 and CD62P, two activated platelet surface markers. Results showed that all the water extracts (1 mg/ml) could significantly suppress human platelet aggregation in vitro (P<0.01), but extracts from three categories exhibited different inhibitory effects on expression of CD41 and CD62P respectively, suggesting the different properties for Huoxuehuayu. We concluded that combined use of Huoxuehuayu herbs may have potent therapeutic effects against platelet-related diseases in clinical contexts. | |||
TO cite this article:TAO Li,ZHANG Lei,RUAN Junshan, et al. Antiplatelet Profiles of Six Water Extracts from Medicinal Herbs for Activating Blood and Resolving Stasis[OL].[ 5 December 2013] http://en.paper.edu.cn/en_releasepaper/content/4573339 |
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