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	1. The antidepressant-like effect of Cynanchum otophyllum
	YANG Qiongxiong,HUANG Xiao-yan
	Traditional Chinese Medicine and Pharmacology 17 August 2011
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	Abstract:In the course of screening for antidepressant from medicinal plants by the despair mice models, the total glycosides from Cynanchum otophyllum (TGCO) showed potent antidepressant effect by using fluoxetine as positive control. The mice were administered intragastrically with TGCO once a day for 5 days at doses of 10 mg/kg, 20mg/kg, 40mg/kg and 80mg/kg. Treating with TGCO significantly decreased the mice immobility time in tail suspension test (40, 80mg/kg, p<0.01) and in forced swim test (80mg/kg, p<0.01). Compared with blank control group, the treatment with TGCO decreased the traveled distance during test without statistical signi?cantly in the locomotor activity test. Treating mice with TGCO at the doses of 40 and 80 mg/kg significantly antagonized reserpine-induced ptosis and hypothermia, suggesting that the antidepressant effect of TGCO may be mediated via central monoaminergic neurotransmitter system.
	TO cite this article:YANG Qiongxiong,HUANG Xiao-yan. The antidepressant-like effect of Cynanchum otophyllum[OL].[17 August 2011] http://en.paper.edu.cn/en_releasepaper/content/4439358


	2. In-vitro Inhibitory Effect of Methanol Extracts of Chinese Herbal Drugs on Supercoiling Activity of Bacterial DNA Gyrase
	XU Hui,YAO Pan,LIN Guodong,CHEN Weiwen
	Traditional Chinese Medicine and Pharmacology 22 February 2011
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	Abstract:A large number of Chinese herbal drugs (CHDs) exhibit antibacterial activities both in vivo and in vitro, but until now little is known regarding their inhibitory mechanisms. Bacterial DNA gyrase is a proven target for antibacterial agents. Aim of this study was to investigate the in-vitro inhibitory effect of methanol extracts of CHDs against supercoiling activity of bacterial DNA gyrase. Fifteen CHDs were selected and extracted with methanol, respectively. Inhibitory effect of the extracts on DNA gyrase was tested using gel-based DNA supercoiling assay. Among fifteen CHDs tested, methanol extracts of Lonicerae Japonicae Flos (S2), Taraxaci Herba (S7), Glycyrrhizae Radix et Rhizoma Praeparata cum Melle (S8) demonstrated an obvious inhibitory effect against supercoiling activity of DNA gyrase, and the others were either less active or could not be determined with the present method. Moreover, it was likely that S7 and S8 inhibit gyrase in a concentration-dependent manner. In conclusion, DNA supercoiling assay is a promising method to study the inhibitory activity of CHDs on bacterial DNA gyrase. Some CHDs do have gyrase-inhibitory activity as proposed. Further investigations are needed to elucidate the inhibition mechanism of these CHDs on supercoiling activity of gyrase.
	TO cite this article:XU Hui,YAO Pan,LIN Guodong, et al. In-vitro Inhibitory Effect of Methanol Extracts of Chinese Herbal Drugs on Supercoiling Activity of Bacterial DNA Gyrase[OL].[22 February 2011] http://en.paper.edu.cn/en_releasepaper/content/4411791

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	3. Factors Affecting Embryogenic Callus Production and Plant Regeneration from Anther Culture of Bupleurum chinense
	YANG Chengmin,ZHAO Yukai,WEI Jianhe,ZHAO Lizi,SUI Chun,Zhang Zhen,CUI Luying
	Traditional Chinese Medicine and Pharmacology 28 January 2011
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	Abstract:To evaluate the influences of the genotypes, anther developmental stages and cultural conditions on the efficiency of embryogenic callus induction and plant regeneration in the anthers culture of Bupleurum chinense. Methods The different effects such as four genotypes, plant growth regulators, and temperature condition were compared in the experiments. Results The most embryogenic calli was achieved for the genotypes 'ZCYH', 'Z4' and 'Z5' at the early- to middle-uninucleate stages, for genotype 'ZPM1' at the tetrad stage. Cold pretreatment increased the production of the embryogenic callus, and 4-d cold pretreatment improved the production of embryogenic callus from 0 to 2.2% and 5.0% for genotypes 'ZPM1' and 'ZCYH', respectively. No embryogenic callus were induced in the medium containing less than 0.75 mg/L 2,4-D. The highest regeneration rate (34.6%) was obtained in the half-strength MS salts regeneration medium supplemented with BA 0.1 mg/L. The low concentration BA was able to promote the embryogenic callus formation and subsequent plantlet regeneration via somatic embryogenesis. Chromosome counting of regenerated plantlets showed mostly diploid plant (2n=12) with only one haploid plant (n=6). Because of the low rate of microspore embryo formation, we only track the process of embryogenesis from the connective tissue, instead of microspore by histological observations. Conclusion This study developed an efficient system embryogenic for callus induction and plant regeneration system from anthers of B. chinense. This is the first report on the haploid plantlet through the anther culture of B. chinense.
	TO cite this article:YANG Chengmin,ZHAO Yukai,WEI Jianhe, et al. Factors Affecting Embryogenic Callus Production and Plant Regeneration from Anther Culture of Bupleurum chinense[OL].[28 January 2011] http://en.paper.edu.cn/en_releasepaper/content/4409604


	4. Preparation and Characterization of Resveratrol Molecularly Imprinted Polymeric Microspheres
	Hong Meihua,Chen Yuantao
	Traditional Chinese Medicine and Pharmacology 25 June 2010
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	Abstract:The molecularly imprinted polymeric microspheres (MIPMs) have been successfully prepared by a single-step swelling and polymerization in polar solvent using the polystyrene particles as seeds, and resveratrol as template molecule. The resveratrol-MIPMs were characterized with scanning electronic microscope. The synthetic condition and the adsorption properties were also studied. It was found that the microspheres with concave-dipression structure had large surface area and lots of binding sites, effectively raising the combination rate and imprinted capacity.
	TO cite this article:Hong Meihua,Chen Yuantao. Preparation and Characterization of Resveratrol Molecularly Imprinted Polymeric Microspheres[OL].[25 June 2010] http://en.paper.edu.cn/en_releasepaper/content/4377209


	5. Pharmacological effects on the composite Salvia miltiorrhiza combined with Acanthopanax senticosus injection of the Chinese herbal medicine preparation in rats with Coronary Atherosclerotic Heart Disease
	Xin Wang,Tingli Li,Yinfeng Tan
	Traditional Chinese Medicine and Pharmacology 24 November 2009
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	Abstract:To investigate the mechanism of suppressive effect of Chinese medicine on Coronary Atherosclerotic Heart Disease (IHD) by observing the effect of Salvia miltiorrhiza injection coordinated with Acanthopanax senticosus injection（MSAI）on the acute myocardial ischemia rat. The optimal formula of MSAI was ascertained using design by uniform distribution. From pharmacodynamics, the rat was applied with isolated heart perfusion method, for measuring Coronary Artery Fluence . Further, Coronary Artery in rat was received physic liquor by intravenous injection using constant flow pump to determine left ventricular systolic pressure (LVSP) , left ventricular maximum pressure variation rate（LVMPVR）and left ventricular end-diastolic pressure(LVEDP). The MSAI was found that could significantly increase CF of the isolated heart of the rats(P<0.01)，compared with SI and AI control group, respectively ; in addition，the effect of Formula (Ⅲ)（syringoside : protocatechuic aldehyde = 1:1.25）is the optimization. The results of hemodynamic effect of acute myocardial ischemia in 15min rat treated with MSAI demonstrated that MSAI could remarkably raise LVSP, LVMPVR（±dp/dtmax）and lower LVEDP. Additionally, the effect on resisting acute-myocardial-ischemia of MSAI group was better than that of SI group and AI group(P<0.01). The mechanism of suppressive effect of MSAI on IHD of may be realized by increasing CF, elevating LVSP, LVMPVR（±dp/dtmax），and lowering LVEDP.
	TO cite this article:Xin Wang,Tingli Li,Yinfeng Tan. Pharmacological effects on the composite Salvia miltiorrhiza combined with Acanthopanax senticosus injection of the Chinese herbal medicine preparation in rats with Coronary Atherosclerotic Heart Disease [OL].[24 November 2009] http://en.paper.edu.cn/en_releasepaper/content/36963


	6. Diuretic activity and kidney medulla AQP1, AQP2, AQP3, V2R expression of the aqueous extract of sclerotia of Polyporus umbellatus FRIES in normal rats
	Guowei Zhang,Xing Zeng,Han Ling,Wei Jian＇an,Hang Haiding
	Traditional Chinese Medicine and Pharmacology 17 November 2009
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	Abstract:The aim of the present study was to evaluate the diuretic effect on the urinary electrolyte concentration(Na+, K+, Cl-) and regulation of the relative mRNA expression of aquaporin-1(AQP1), aquaporin-2(AQP2), aquaporin-3(AQP3) and vasopressin V2 receptor (V2R)post oral administration of sclerotia of P.umbellata aqueous extract in normal rats. Aqueous extract of sclerotia of Polyporus umbellatus (50mg/kg, 250mg/kg, 500mg/kg) or the reference drug, furosemide (10mg/kg) were administrated orally to male SD rats and their urine output was quantified and collected 24h and 8days after the treatment. The kidney medulla AQP1, AQP2, AQP3 and V2R mRNA relative expressions were measured with RT-PCR. After single dose of the exact of sclerotia of P.umbellata, urine output was found to be significantly increased, which began at 4h, and at 24h after the treatment, the sclerotia of Polyporus umbellatus extract and furosemide treatment produced the similar total volume of urine excreted. The extract increase urinary levels of Na+, K+, Cl-, to about the same extent, while furosemide increased urinary levels of Na+ and Cl-. After the 8-day doses, all two substances induced significant diuresis, natriuresis and chloriuresis. These two substances don’t regulate the AQP1 and AQP3 mRNA level in normal rat kidney medulla. The AQP2 mRNA level of sclerotia of P.umbellata extract was down-regulated significantly, the V2R mRNA level of sclerotia of P.umbellata extract 50mg/kg dose group and 250mg/kg dose group were down-regulated significantly too. Interestingly, the low-dose group had higher effect on regulation of AQP2 and V2R mRNA level. Aqueous extract of sclerotia of Polyporus umbellatus has conspicuous diuretic effect confirming its ethnopharmacological use. From the pattern of excretion of water, sodium, potassium, cholorine, AQP2 and V2R mRNA level, it may be logically concluded that it has effect from down-regulating AQP2, and down-regulate AQP2 by down-regulating V2R.
	TO cite this article:Guowei Zhang,Xing Zeng,Han Ling, et al. Diuretic activity and kidney medulla AQP1, AQP2, AQP3, V2R expression of the aqueous extract of sclerotia of Polyporus umbellatus FRIES in normal rats[J].J Ethnopharmacol ，2010年，128卷，2期，433 ~ 437


	7. Research advance of safflower on chemical composition
	Li Junfu,Yin Rongli,Wei Juan,Li Xiaoyi,Luo Yan
	Traditional Chinese Medicine and Pharmacology 22 September 2008
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	Abstract:Safflower,as a plant of Carthamus L.in compositae,is one of blood-activating and stasis-eliminating Chinese medicines,Safflower Yellow is mainly its active component. Modern studies shows that Safflower has significant effects on Cardiocerebral Vascular Diseases This text overviews the reseach advance of safflower from chemical composition, pharmacologic action,pharmacokineticcs and toxicology respectively.
	TO cite this article:Li Junfu,Yin Rongli,Wei Juan, et al. Research advance of safflower on chemical composition[OL].[22 September 2008] http://en.paper.edu.cn/en_releasepaper/content/24204


	8. Fingerprint analysis of different Panax herbal species by HPLC-UV method
	Feng Zeng,Wang Xiaoming,Yang Min,Lu Zhiqiang,Guo Dean
	Traditional Chinese Medicine and Pharmacology 15 December 2007
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	Abstract:To establish a method for distinguishing different commercial samples of Panax species including notoginseng, cultivated ginseng (Chinese ginseng and Korean ginseng), wild ginseng, red ginseng and three types of American ginsengs and one American ginseng preparation with their HPLC fingerprints, so as to assure the quality of different commercial samples of Panax species, HPLC-UV method was used to establish their fingerprints; Zorbax Extend C18 (250mm×4.6 mm , 5μm) was used as analytical column, and acetonitrile/ KH2PO4 aqueous solution was used as mobile phase with gradient elution. The resultes showed that the fingerprints of different commercial samples of Panax species were variant in their holistic chromatograms and some specific constituents. The method is reliable, reproducible and simple, and can be used as an analytical method for the routine material discrimination of different commercial samples of Panax species.
	TO cite this article:Feng Zeng,Wang Xiaoming,Yang Min, et al. Fingerprint analysis of different Panax herbal species by HPLC-UV method[OL].[15 December 2007] http://en.paper.edu.cn/en_releasepaper/content/16989


	9. Induction of Apoptosis and G2/M Cell Cycle Arrest by Oridonin in Human Gastric Cancer BGC-823 Cells
	Jian Han,Ye Min,Qiao Xue,Wu Wanying,Qu Guiqin,Guo Dean
	Traditional Chinese Medicine and Pharmacology 14 December 2007
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	Abstract:The in vitro apoptosis-induction effects of oridonin on gastric tumor cells BGC-823 and its effects on cell cycle, mitochondrial membrane potential and intracellular Ca2+ were investigated to shed light on the mode of its anticancer action. The results showed that oridonin inhibited BGC-823 cells growth with IC50 of 22.21 μM. It induced apoptosis in a dose-dependent manner. In addition, it could decrease mitochondria membrane potential, increase intracellular Ca2+, and activate pro-caspase 3. BGC-823 cells were arrested in G2/M cell cycle phase with lower expression of cyclin A protein. The up-regulation of p53 was observed before apoptosis occurred and cell cycle arrest. It suggested that oridonin inhibits the proliferation of BGC-823 cells through G2/M cell cycle arrest and apoptosis induction, which is mediated by influx of Ca2+, up-regulation of p53, activation of caspase-3, and down-regulation of cyclin A.
	TO cite this article:Jian Han,Ye Min,Qiao Xue, et al. Induction of Apoptosis and G2/M Cell Cycle Arrest by Oridonin in Human Gastric Cancer BGC-823 Cells[OL].[14 December 2007] http://en.paper.edu.cn/en_releasepaper/content/16926

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