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There are 18 papers published in subject: > since this site started. |
Results per page: | 18 Total, 2 Pages | << First < Previous 1 2 |
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1. Synthesis and Characterization of Zinc 5-(N-(2-hydroxybenzyl)- aminophenyl)-10,15,20-triphenylporphyrinate | |||
XU Gaohui,FENG Zhiqiang,HUANG Wei,JIANG Jiaxun,HU Chuanjiang | |||
Chemistry 14 November 2012 | |||
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Abstract:We have designed a new porphyrin, H2HATPP (5-(N-(2-hydroxybenzyl)-aminophenyl)- 10,15,20-triphenylporphyrin), to study the influence of the structural change on hydrogen bonding interactions. The corresponding complex [Zn(HATPP)] has been synthesized, and characterized by X-ray crystallography, 1H NMR etc. The complex crystallizes in the triclinic system, space group P-1, lattice parameters: a=12.163(2) Å, b=13.402(3) Å, c=15.794(2) Å,α = 66.27(3) , β=74.24(3) , γ = 78.86 , V=2258.0(8) Å3, Z=2, μ=0.584 mm-1, F(000)=828, Dc=1.175 gocm-3, R1=0.0714 and wR2=0.1906. The structure shows the phenol oxygen is involved in double hydrogen bonds: one is within N-(2-hydroxybenzyl)aminophenyl group, the other is between phenol oxygen and N atom of another symmetry related molecule. The nitrogen in the N-(2-hydroxybenzyl)aminophenyl group is sp3 hybridized. Comparing with [Zn(SATPP)] species (H2SATPP, 5-(salicylideneaminophenyl)-10,15,20- triphenylporphyrin), the phenol oxygen in [Zn(HATPP)] is away from the porphyrin center, too far from zinc to form an intramolecular hydrogen bond with an axial ligand. Such structural change also cause the binding affinity of [Zn(HATPP)] to methanol to be much smaller than that of SATPP species. | |||
TO cite this article:XU Gaohui,FENG Zhiqiang,HUANG Wei, et al. Synthesis and Characterization of Zinc 5-(N-(2-hydroxybenzyl)- aminophenyl)-10,15,20-triphenylporphyrinate[OL].[14 November 2012] http://en.paper.edu.cn/en_releasepaper/content/4494126 |
2. Synthesis, visible light photocleavage, antiproliferative and cellular uptake properties of ruthenium complex [Ru(phen)2(mitatp)]2+ | |||
Yu Huijuan,Yu Lin,Hao Zhifeng,Zhou Lihua,Xie Zhenming | |||
Chemistry 18 April 2012 | |||
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Abstract:A new ruthenium complex [Ru(phen)2(mitatp)]2+ ( phen = 1,10-phenanthroline, mitatp = 5-methoxy-isatino[1,2-b]-1,4,8,9-tetraazatriphenylene) has been synthesized and characterized. The interaction of the complex with DNA has been studied and the results indicate that [Ru(phen)2(mitatp)]2+ could efficiently photocleave pBR322 DNA under irradiation at visible light and the singlet oxygen 1O2 was proved to be reactive species in the photocleavage process. The cytotoxicity has also been evaluated by MTT method, and [Ru(phen)2(mitatp)]2+ shows prominent anticancer activity against various cancer cells. Live cell imaging study and flow cytometric analysis demonstrate that the complex could cross cell membrane accumulating in the nucleus and inducing cell death by induction of G0/G1 cells cycle arrest and apoptosis. | |||
TO cite this article:Yu Huijuan,Yu Lin,Hao Zhifeng, et al. Synthesis, visible light photocleavage, antiproliferative and cellular uptake properties of ruthenium complex [Ru(phen)2(mitatp)]2+[OL].[18 April 2012] http://en.paper.edu.cn/en_releasepaper/content/4474481 |
3. Spectral studies of interaction between C-terminal domain on Euplotes Octocarinatus centrin and melittin | |||
Zhao Yaqin,Yan Jun,Liang Aihua,Yang Binsheng | |||
Chemistry 31 October 2011 | |||
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Abstract:Centrin is a low molecular mass (20 kDa) protein that belongs to the EF-hand superfamily of calcium-binding proteins. It plays various roles in a number of different cellular functions. The interactions between C-terminal half of Euplotes octocarinatus centrin (C-EoCen) and melittin (ME) were studied by UV spectra and fluorescence spectra in the presence of 1.0 mM Ca2+. In 100 mM N-2-hydroxyethy-lpiperazine-N-2-ethanesulfonic acid (Hepes) and 150 mM NaCl at pH 7.4, UV absorbance of ME at 280 nm was increased significantly in the presence of Ca2+-saturated C-EoCen (holo-C-EoCen) suggesting the interaction of ME with holo-C-EoCen. In addition, the reaction has been measured by fluorescence spectra under the same experimental conditions. In 100 mM Hepes and 150 mM NaCl at pH 7.4, fluorescence emission of ME appeared at about 353 nm. With the addition of holo-C-EoCen (4.1×10-4 M), fluorescence emission of ME was blue-shifted to 335 nm in virtue of micro-environmental changes of the peptide, indicating that new complex of ME/holo-C-EoCen was formed. Meanwhile, fluorescence emission of ME was increased markedly. On the basis of the result of fluorescence titration curves, the 1:1 stoichiometric ratio of holo-C-EoCen to ME was confirmed. And the conditional binding constant of holo-C-EoCen with ME was calculated to be log KME-holo-C-EoCen = 6.18±0.31. | |||
TO cite this article:Zhao Yaqin,Yan Jun,Liang Aihua, et al. Spectral studies of interaction between C-terminal domain on Euplotes Octocarinatus centrin and melittin[OL].[31 October 2011] http://en.paper.edu.cn/en_releasepaper/content/4447906 |
4. Syntheses, structures and properties of a series of non-heme alkoxide-Fe(III) complexes as models for lipoxygenase | |||
Wu Guiling,Mei Fusheng,Li Dongfeng | |||
Chemistry 19 April 2011 | |||
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Abstract:Treatment of Fe(ClO4)2o6H2O or Fe(ClO4)3o9H2O with a benzimidazolyl-rich ligand, N,N,N',N'-tetrakis[(1-methyl-2-benzimidazolyl)methyl]-1,2-ethanediamine (medtb) in alcohol/MeCN give a mononuclear ferrous complex, [FeII(medtb)](ClO4)2oCH3CNoCH3OH (1), and four non-heme alkoxide-iron(III) complexes, [FeIII(OMe)(medtb)](ClO4)2oH2O (2, alcohol = MeOH), [FeIII(OEt)(Hmedtb)](ClO4)3oCH3CN (3, alcohol = EtOH), [FeIII(OPrn)(Hmedtb)](ClO4)3o- nPrOHo2CH3CN (4, alcohol = n-PrOH), and [FeIII(OBun)(Hmedtb)](ClO4)3o3CH3CNoH2O (5, alcohol = n-BuOH), respectively. The alkoxideiron(III) complexes all show 1) a Fe(III)?-OR center (R = Me, 2; Et, 3; nPr, 4; nBu, 5) with the FeO bond distances in the range of 1.781-?1.816 , and 2) yellow color and an intense electronic transition around 370 nm. The alkoxide-iron(III) complexes can be reduced by organic compounds with cis,cis-1,4-diene moiety via the hydrogen atom abstraction reaction (HAAR). | |||
TO cite this article:Wu Guiling,Mei Fusheng,Li Dongfeng. Syntheses, structures and properties of a series of non-heme alkoxide-Fe(III) complexes as models for lipoxygenase[OL].[19 April 2011] http://en.paper.edu.cn/en_releasepaper/content/4422338 |
5. Controllable synthesis of BSA-conjugated hydroxyapatite micro-/nano- particles | |||
Fang Dan,Cao Ying,Yang Lin,Wang Kui,Wang Huajie | |||
Chemistry 24 November 2010 | |||
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Abstract:Controllable synthesis of hydroxyapatite with different size and morphology has drawn more and more attention these days due to the Size/morphology-dependent cytotoxicity of hydroxyapatite in tumor treatments. In this study, a facile method was developed for the controllable synthesis of bovine serum albumin-conjugated micro- and nano- hydroxyapatite. Scanning electron microscope, Fourier transform infrared, energy dispersive system analysis and X-ray powder diffraction displayed that the pH value was the key factor affecting the morphology, size and crystal structure of products. The optimal pH value for the flocculatidn hydroxyapatite micro-crystals with size 1.82 ± 0.19 μm in the diameter and amorphous hydroxyapatite nanoparticles with size 167 ± 12 nm in the diameter was 7.97 and 6.5, respectively. | |||
TO cite this article:Fang Dan,Cao Ying,Yang Lin, et al. Controllable synthesis of BSA-conjugated hydroxyapatite micro-/nano- particles[OL].[24 November 2010] http://en.paper.edu.cn/en_releasepaper/content/4392328 |
6. Non-heme iron(II/III) complexes that model the reactivity of lipoxygenase | |||
Mei Fusheng ,Ou Chunping ,Wu Guiling ,Cao Li ,Han Fang ,Meng Xianggao ,Li Ji ,Li Dongfeng ,Liao Zhanru | |||
Chemistry 10 February 2010 | |||
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Abstract:We have synthesized and characterized three ferrous/ferric complexes of a N6 hexadentate ligand, N,N,N′,N′-tetrakis(2-benzimidazolyl-methyl)ortho-diamine-trans-cyclohexane (ctb), [FeII(ctb)](ClO4)2EtOH (1), [FeIII(OEt)(Hctb)](ClO4)3EtOH (2), and [FeIII(OMe)(Hctb)] ¬ (ClO4)33MeOH4.5H2O (3), as the models of lipoxygenases. The lipoxygenase activities of the complexes were checked and the results indicate that ferrous complex 1 is inactive while ferric alkoxide complexes 2 and 3 show the catalytic activity. | |||
TO cite this article:Mei Fusheng ,Ou Chunping ,Wu Guiling , et al. Non-heme iron(II/III) complexes that model the reactivity of lipoxygenase[OL].[10 February 2010] http://en.paper.edu.cn/en_releasepaper/content/40148 |
7. Synthesis, characterization and DNA-binding study of Ruthenium(II) complex: [Ru(bpy)2(ipbh)](ClO4)2 | |||
Liu Yunjun,Mei Wenjie,Wang Ruijie,Jian Liuqing,Wang Na | |||
Chemistry 15 June 2006 | |||
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Abstract:In the study, the DNA-binding of ruthenium(II) mixed-ligand complex containing 2,2\\\\\\\ | |||
TO cite this article:Liu Yunjun,Mei Wenjie,Wang Ruijie, et al. Synthesis, characterization and DNA-binding study of Ruthenium(II) complex: [Ru(bpy)2(ipbh)](ClO4)2[J]. |
8. The Study of the Role of Glu 101 in Maintaining the Proper Conformation of Euplotes Octocarinatus Centrin | |||
Li Guoting,Wang Zhijun,Zhao Yaqin,Ren Liexiang,Yang Binsheng | |||
Chemistry 23 May 2006 | |||
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Abstract:Glu is highly conserved as the first amino acid of E-helix of the EF-hand protein. In this paper, Glu 101, the first amino acid of the E-helix of the third EF-hand motif in EoCen was mutated to be Lys by the method of site direct mutation. TNS and Tb3+ were used as probes in the study of the effect of this mutation to the proper conformation of EoCen. Results indicate the mutation protein (E101K) displays an increased hydrophobic exposure surface and a different Tb3+ binding characteristic. It proves that the conformation of EoCen has been altered largely by this mutation. The general conditional binding constant of Tb3+ to the three loops of EF-hand sites I, II, III in E101K was calculated to be (5.64 ± 0.57) × 105 M-1. | |||
TO cite this article:Li Guoting,Wang Zhijun,Zhao Yaqin, et al. The Study of the Role of Glu 101 in Maintaining the Proper Conformation of Euplotes Octocarinatus Centrin[OL].[23 May 2006] http://en.paper.edu.cn/en_releasepaper/content/6761 |
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