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1. Glutathione-Capped Gold Nanoparticles-Based Photoacoustic Sensor for Label-Free Detection of Lead Ions | |||
SHI Ruyi,LIU Xiangjiang | |||
Chemistry 18 April 2017 | |||
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Abstract:The photoacoustic signal generated by laser-induced nanobubbles (PA-LINB) proved to be a sensitive tool to monitor aggregation of gold nanoparticles. Here, a simple and label-free photoacoustic method for the rapid detection of Pb2+ in aqueous phase was developed. Due to the high affinity of Pb2+ ions to glutathione, the presence of Pb2+ led to the aggregation of glutathione conjugated gold nanoparticles (GSH-GNPs). Hence, by measuring the variation of the PA-LINB signal after the aggregation of GSH-GNPs, Pb2+ can be quantified. A low detection limit for Pb2+ (42 nM) and a wide linear working range (42 ~ 1000 nM) was achieved. Furthermore, the proposed method showed good selectivity against other metal ions. | |||
TO cite this article:SHI Ruyi,LIU Xiangjiang. Glutathione-Capped Gold Nanoparticles-Based Photoacoustic Sensor for Label-Free Detection of Lead Ions[OL].[18 April 2017] http://en.paper.edu.cn/en_releasepaper/content/4725588 |
2. The development of the material for FA detection for Environmental and Health Monitoring | |||
Bi Anyao,Yang Shuqi,Liu Min,Wang Xiaobo,Zeng Wenbin | |||
Chemistry 18 April 2017 | |||
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Abstract:Formaldehyde (FA), as a vital industrial chemical, is widely used in building materials and numerous living products. It has become one of the most important air pollutants in residential and industrial occupational environments. Studies have shown FA is easy to react with nucleophilic material leading to the formation of DNA damage. Additionally, the Alzheimer's disease has also related to the intake of FA. The concentration of FA in our surroundings especially in urban environment has attracted increasingly attention. Thus, developing a rapid, sensitive and facile method to determine the concentration levels of FA becomes highly desirable. Up to now, many types of FA sensing methods have been applied to detect and quantify the FA concentration. Herein, we summarized the recent development of the material for FA detection and their application in environmental and health monitoring, with a focus on fluorescent probe, nanomaterials, and biomolecules. Nevertheless, the further trend of related development from lab to indoors was also proposed. | |||
TO cite this article:Bi Anyao,Yang Shuqi,Liu Min, et al. The development of the material for FA detection for Environmental and Health Monitoring[OL].[18 April 2017] http://en.paper.edu.cn/en_releasepaper/content/4724917 |
3. The state of art of novel gene detection technique | |||
Zhang Hailiang,Liu Xiaohui,Liu Meihui,Gao Tang,Yuzhao Huang,Zeng Wenbin | |||
Chemistry 14 April 2017 | |||
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Abstract:Gene detection plays an important role in public health and consumer finances cause its prominent functions in precision medicine, pathogens detection and species identification. What's more,the announcement of Precision Medicine Initiative would strengthen its status further in many aspects. Therefore, rapid and simplified gene detection methods are in urgent demand to meet the practical use. During the last decades, gene detection techniques have advanced considerably by integrating various strategies such as microassay, nanotechnologies and electrochemical methods. Herein, we summarized the recent development of gene detection based on the gene detection methods (optical, electrochemical), and highlighted those techniques with the potentials to realize point-of-Care (POC) testing. Additionally, gene detection principle, amplification strategies and their applications are also discussed. | |||
TO cite this article:Zhang Hailiang,Liu Xiaohui,Liu Meihui, et al. The state of art of novel gene detection technique[OL].[14 April 2017] http://en.paper.edu.cn/en_releasepaper/content/4724905 |
4. Effective Degradation of Nitrotoluenes in Wastewater by Heterogeneous Catalytic Ozonation in the presence of Calcium Oxide (CaO/O3) | |||
LIAO Minhui,CHEN Jida,LI Lingxing,HE Huirong,LU Lansi,FU Denglin | |||
Chemistry 12 April 2017 | |||
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Abstract:CaO was utilized as a heterogeneous catalyst for ozonation of nitrotoluenes wastewater. Results showed that CaO could promote ozone to generate more hydroxyl radicals (oOHs) that non-selectively degrade p-nitrotoluene (PNT) at an over double oxidation rate of alone ozone in simulated wastewater. A possible degradation pathway of PNT was proposed by gas chromatography/mass spectr ometry (GC/MS) analysis. CaO maintained a good pH and catalytic activity after several repeated use in CaO/O3. The removal efficiency of chemical oxygen demand (CODcr), content of nitrotoluenes, chromaticity and odour reached 97.97 %, 99.96%, 100% and 100% in wastewater at the same time, respectively. | |||
TO cite this article:LIAO Minhui,CHEN Jida,LI Lingxing, et al. Effective Degradation of Nitrotoluenes in Wastewater by Heterogeneous Catalytic Ozonation in the presence of Calcium Oxide (CaO/O3)[OL].[12 April 2017] http://en.paper.edu.cn/en_releasepaper/content/4724431 |
5. A sensitive PEC immunoassay based silicon phthalocyanine-decorated TiO2 mesocrystal | |||
Zheng Hongli,Wang Huixia,LI Yilin,Chen Sihong,Dai Hong | |||
Chemistry 31 October 2016 | |||
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Abstract:Herein, a new photoelectrochemical sensor for a?atoxin B1 (AFB1) detection was established based on the all-carbon nanohybrids as transducer scaffold accompanied with quasi-octahedral TiO2 mesocrystal (QOTM) absorbed dentritic Si phthalocyanines (SiPcs) as the efficient bioprobe. Specifically, The dentritic SiPcs sensitized QOTM presented better photocurrent response and stability in comparison with QOTM alone due to impressive light-harvesting capability of the dentritic SiPcs. The all-carbon nanocomposites exhibited fine photoelectric properties due to the photo-generated electrons of carbon quantum dots , which evidently expedited the electron transport, and the nanohybrids were first employed as affinity support to anchor AFB1 antibody.Under light irradiation, the photo-induced electrons of SiPcs migrated to the QOTM, and successively transferred to carbon quantum dots as electron relay mediator then via carbon nanohorns to the electrode surface . In this competitive immunosensor, the AFB1 standards compete with the labeled AFB1, leading to photocurrent decreased with the increasing target concentration in a wide linear range of 10-6-102 ng/mL. The newly developed methodology provided a versatile approach for ultrasensitive detection of small molecules. | |||
TO cite this article:Zheng Hongli,Wang Huixia,LI Yilin, et al. A sensitive PEC immunoassay based silicon phthalocyanine-decorated TiO2 mesocrystal[OL].[31 October 2016] http://en.paper.edu.cn/en_releasepaper/content/4706749 |
6. A novel non-enzymatic hydrogen peroxide sensor based on Mn2O3-Fe2O3 loaded carbon fibers | |||
LI Can,LI Mian,BO Xiangjie,GUO Liping | |||
Chemistry 10 June 2016 | |||
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Abstract:In this paper, a novel manganese-iron oxide embedded carbon fibers (Mn2O3-Fe2O3/CFs) has been successfully prepared for the first time through electrospinning and calcination. A series of samples with various Mn/Fe molar ratios (1:0, 3:1, 1:1, 1:3, 0:1) were synthesized by the same way to optimize catalytic ability. Structural characterizations reveal that Mn2O3-Fe2O3/CFs possesses 3D net-like structure. Electrochemical measurements reveal that Mn2O3-Fe2O3/CFs (3:1) shows the best catalysis ability for hydrogen peroxide (H2O2) reduction and acquires better detection parameters (such as: the fast response time (< 2 s), wide linear range (0.01-15.4 mM), good stability, and surpassingly selective capability). Such excellent performances are attributed to the following three factors: (1) the high catalytic ability of the Mn phase in the composites; (2) the 3D net-like CFs with high electrical conductivity, large surface area and more exposed active sites; (3) the synergistic effect between Mn2O3 and Fe2O3. In addition, Mn2O3-Fe2O3/CFs (3:1) can be applied to the analysis of H2O2 in human serum samples with satisfactory results. | |||
TO cite this article:LI Can,LI Mian,BO Xiangjie, et al. A novel non-enzymatic hydrogen peroxide sensor based on Mn2O3-Fe2O3 loaded carbon fibers[OL].[10 June 2016] http://en.paper.edu.cn/en_releasepaper/content/4697548 |
7. Simultaneous electrochemical determination of trace amounts of Cd2+ and Pb2+ ions using thiolated polyaniline nanofiber modified glassy carbon electrodes | |||
Huang Hui,Wang Chunlei,Zhu Wencai,Ma Houyi | |||
Chemistry 06 June 2016 | |||
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Abstract:Stable and highly dispersed polyaniline (PANI) nanofiber aqueous colloids prepared via a facile chemical method were used to modify glassy carbon electrodes (GCEs), with the help of mercaptosuccinic acid (MSA). Due to the effective combination of the good conductivity and network structure of PANI nanofibers with the complexing capacity of MSA, the resulting modified electrodes could be used to sensitively and simultaneously determine trace amounts of Cd2+ and Pb2+ ions by means of differential pulse anodic stripping voltammetry (DPASV), with the outstanding preconcentration efficiency and detection sensitivity. The linear calibration curve for Pb2+ ions ranged from 0.2 to 50 μg L-1 and that for Cd2+ions from 1.0 to 100 μg L-1; the corresponding detection limits (S/N = 3) were 0.1 μg L-1 for Pb2+ and 0.5 μg L-1 for Cd2+ respectively. In particular, the thiolated PANI nanofiber modified GCEs were successfully applied to the simultaneous detection of Cd2+ and Pb2+ ions in waste water samples. The present study provides a new path for fabricating high performance modified electrodes suitable for the highly sensitive and simultaneous determination of trace amounts of heavy metal ions in aqueous solutions. | |||
TO cite this article:Huang Hui,Wang Chunlei,Zhu Wencai, et al. Simultaneous electrochemical determination of trace amounts of Cd2+ and Pb2+ ions using thiolated polyaniline nanofiber modified glassy carbon electrodes[OL].[ 6 June 2016] http://en.paper.edu.cn/en_releasepaper/content/4696479 |
8. Affinity Zirconium Oxide-Silica Composite Monolithic Column for Selective Enrichment and Determination of Nucleosides Modification | |||
JIANG Han-Peng,CHU Jie-Mei,LAN Meng-Dan,LIU Ping,YANG Na,ZHENG Fang,FENG Yu-Qi,YUAN Bi-Feng | |||
Chemistry 20 May 2016 | |||
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Abstract:More than 140 modified nucleosides have been identified in RNA. Determination of endogenous modified nucleosides in biological fluids may serve as non-invasive disease diagnostic strategy. However, detection of the modified nucleosides in biological fluids is challenging, especially for the low abundant modified nucleosides due to the serious matrix interferences of biological fluids. Here, we developed a facile preparation strategy and successfully synthesized zirconium oxide-silica (ZrO2/SiO2) composite capillary monolithic column that exhibited excellent performance for the selective enrichment of cis-diol-containing compounds. Compared with the boronate-based affinity monolith, the ZrO2/SiO2 monolith showed ~ 2 orders of magnitude higher extraction capacity and can be used under physiological pH (pH 6.5-7.5). Using the prepared ZrO2/SiO2 composite monolith, we further established an online solid-phase microextraction (SPME) in combination with liquid chromatography-mass spectrometry (online SPME-LC-MS/MS) analysis for the comprehensive profiling nucleosides modification in human urine. Our results showed that 68 cis-diol-containing nucleosides and ribosylated compounds were identified in human urine, which is, to the best of our knowledge, the most numbers of cis-diol-containing compounds were determined in a single analysis. It is worth noting that four modified nucleosides were discovered in the human urine for the first time. In addition, the quantification results showed that compared to healthy controls, 16, 11 and 7 ribose conjugates increased more than 2 folds in the urine of gastric cancer, esophagus cancer and lymphoma, respectively. These increased ribose conjugates in cancer patients suggested that the metabolism of these compounds may have important roles in carcinogenesis as well as in serving as indicator of cancers. | |||
TO cite this article:JIANG Han-Peng,CHU Jie-Mei,LAN Meng-Dan, et al. Affinity Zirconium Oxide-Silica Composite Monolithic Column for Selective Enrichment and Determination of Nucleosides Modification[OL].[20 May 2016] http://en.paper.edu.cn/en_releasepaper/content/4691784 |
9. Negative Correlation of RNA Epigenetic Modifications of N6-methyladenosine and 5-methylcytosine with Aging | |||
JIANG Han-Peng,XIONG Jun,HUANG Wei,LAN Meng-Dan,ZENG Huan,FENG Yu-Qi,YUAN Bi-Feng | |||
Chemistry 20 May 2016 | |||
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Abstract:Aging is characterized by progressive decline in physiology and function of adult tissues. Previous studies demonstrated DNA methylation is related to aging. In addition to DNA methylation, reversible RNA modification has recently been proposed to represent another realm for biological regulation in the form of "RNA epigenetics". However, the correlation of emerging RNA epigenetic modifications in aging process is still a mystery. Here we developed an on-line trapping/capillary hydrophilic-interaction liquid chromatography/electrospray ionization-mass spectrometry method for ultra-sensitive and simultaneous quantification of RNA epigenetic modifications of N6-methyladenosine (m6A) and 5-methylcytosine (5-mC) from human blood. We analyzed the contents of m6A and 5-mC in RNA of blood from 260 healthy persons aged from 0 to 88 years old. The results showed that both m6A and 5-mC contents were significantly decreased and highly correlated with aging process. We then established RNA epigenetic modifications age models according to m6A and 5-mC contents with an mean absolute deviation of 6.7 years for m6A and 8.0 years for 5-mC. This study demonstrated RNA epigenetic modifications of m6A and 5-mC represents strong and reproducible marks of chronological age, which could be potentially applied in health assessment and prevention of diseases. | |||
TO cite this article:JIANG Han-Peng,XIONG Jun,HUANG Wei, et al. Negative Correlation of RNA Epigenetic Modifications of N6-methyladenosine and 5-methylcytosine with Aging[OL].[20 May 2016] http://en.paper.edu.cn/en_releasepaper/content/4691753 |
10. Complicated function of dopamine in Aβ-related neurotoxicity: dual interactions with Tyr10 and SNK(26-28) of Aβ | |||
Mengmeng Liu,Yannan Bin,Qingyu Zhai,Jianhong An,Yuting Hou,Juan Xiang | |||
Chemistry 13 May 2016 | |||
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Abstract:With the capability to inhibit the formation of amyloid-β peptides (Aβ) fibril, dopamine (DA) and other catechol derivatives have been considered for the potential treatment of Alzheimer's disease (AD). Such treatment, however, remains debatable because of the diverse functions of Aβ and DA in AD pathology. Moreover, the complicated oxidation accompanying DA has caused the majority of the previous research to focus on the binding of DA oxides onto Aβ. The molecular mechanism by which Aβ interacts with the reduction state of DA, which is correlative with the brain function, should be urgently explored. By controlling rigorous anaerobic experimental conditions, this work investigated the molecular mechanism of the Aβ/DA interaction, and two binding sites were revealed. For the binding of DA, Tyrosine (Tyr10) was identified as the strong binding site (Kd: 0.30 μmoloL-1), and SNK(26-28) segment was the weak binding segment (Kd: 2.92 μmoloL-1). Furthermore, THT fluorescence confirmed DA's positive function of inhibiting Aβ aggregation through its weakly binding with SNK(26-28) segment. Meanwhile, 7-OHCCA fluorescence exhibited DA's negative function of enhancing oOH generation through inhibiting the Aβ/Cu2+ coordination. The viability tests of the neuroblastoma SH-SY5Y cells displayed that the coexistence of DA, Cu2+, and Aβ induced lower cell viability than free Cu2+, indicating the significant negative effect of excessive DA on AD progression. This research revealed the potential DA-induced damage in AD brain, which is significant for understanding the function of DA in AD neuropathology and for designing a DA-related therapeutic strategy for AD. | |||
TO cite this article:Mengmeng Liu,Yannan Bin,Qingyu Zhai, et al. Complicated function of dopamine in Aβ-related neurotoxicity: dual interactions with Tyr10 and SNK(26-28) of Aβ[OL].[13 May 2016] http://en.paper.edu.cn/en_releasepaper/content/4688776 |
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