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1. Determination of thermokinetic parameters of benzylpenicillin hydrolysis with metallo-β-lactamase CcrA from Bacteroides fragilis | |||
Zhou Lisheng,Zhai Le,Liu Chengcheng,Shi Ying,Zhou Yajun,Yang Kewu | |||
Chemistry 24 July 2012 | |||
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Abstract:In this paper, we report the thermokinetic parameters of benzylpenicillin (as the representative of penicillins) hydrolysis with the B1 subclasses MβL CcrA from Bacteroides fragilis. The activation free energy are 87.90±0.03, 88.99±0.01, 89.93±0.04 and 90.93±0.05 kJomol-1 at 293.15, 298.15, 303.15 and 308.15 K. Activation enthalpy is 29.21±0.03 kJomol-1, activation entropy is -200.34±0.08 Jomol-1oK-1, the reaction order is 1.4, and the apparent activation energy E is 31.71 kJomol-1. The summarized thermokinetic data indicated that CcrA prefer to hydrolyze penicillins among three kinds of β-lactam containing antibiotics. | |||
TO cite this article:Zhou Lisheng,Zhai Le,Liu Chengcheng, et al. Determination of thermokinetic parameters of benzylpenicillin hydrolysis with metallo-β-lactamase CcrA from Bacteroides fragilis[OL].[24 July 2012] http://en.paper.edu.cn/en_releasepaper/content/4485582 |
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