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1. Magnetic targeting effect of methotrexate-loaded Fe3O4-PLLA-PEG-PLLA microspheres prepared in supercritical CO2 | |||
TANG Na,WANG Shibin,CHEN Aizheng | |||
Chemical Engineering 13 December 2016 | |||
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Abstract:The magnetic targeting effect of methotrexate-loaded Fe3O4-poly (L-lactide)-poly (ethylene glycol)-poly (L-lactide) magnetic composite microspheres (MTX-Fe3O4-PLLA-PEG-PLLA MCMs, MMCMs) prepared by co-precipitation (C) and microencapsulation (M) in a process of suspension-enhanced dispersion by supercritical CO2 (SpEDS) was evaluated. The observations of movements and aggregations of MMCMs indicate a good magnetic response in vitro. The results of Prussian blue iron-staining in tumor and the distribution of MTX in S-180-bearing KM mice demonstrate that MMCMs with magnetic field induction could effectively target to tumors. The MTX concentration in tumors treated with free MTX, MMCMs(C) and MMCMs(M) were 8.13±0.46 ng/mL, 138.71±66.22 ng/mL and 282.11±9.36 ng/mL, respectively. This reveals that MMCMs(M) with magnetic field induction possessed a much more remarkable targeting effect than MMCMs(C) and free MTX formulations. This study demonstrates that MMCMs(M) could effectively response to the magnetic induction both in vitro and in vivo, and have potential for application in magnetic targeting therapy of solid tumors. ????? | |||
TO cite this article:TANG Na,WANG Shibin,CHEN Aizheng. Magnetic targeting effect of methotrexate-loaded Fe3O4-PLLA-PEG-PLLA microspheres prepared in supercritical CO2[OL].[13 December 2016] http://en.paper.edu.cn/en_releasepaper/content/4713859 |
2. Selective Ethylene Oligomerization with Chromium-based Metal-Organic Framework MIL-100 Evacuated under Different Temperatures | |||
HAN Yang,ZHANG Ying,LIU Suyan,FENG Guangliang,GAO Fei,WANG Hui | |||
Chemical Engineering 08 October 2016 | |||
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Abstract:MIL-100(Cr) was synthesized and evacuated under different temperatures to generate a series of Cr-based heterogeneous catalysts for ethylene slurry oligomerization. Their crystal structures, pore properties and metal oxidation states were characterized by XRD, N-adsorption/desorption and XPS techniques. These catalysts showed moderate catalytic activities for ethylene oligomerization but high selectivities to low carbon olefins C6, C8 and C10. Moreover, the oligomer distributions were different depending on the evacuation temperatures. The XPS results showed that the increase of evacuation temperature below 350 oC caused the reduction of some CrIII active sites in the MIL-100(Cr) structure to CrII active sites, which made the catalytic behavior switch from oligomerization to oligomerization plus polymerization activities. The MIL-100(Cr)-250 catalyst evacuated at 250 oC exhibited the largest BET surface area of 2348 m2og-1 and the highest oligomerization and polymerization activities up to 9.27×105 g/(molCroh) and 0.99×105 g/(molCroh) respectively. The main oligomerization products were low carbon olefins C6, C8 and C10. The by-product polymer from MIL-100(Cr)-250 was also characterized in detail by various techniques. It was found that the polymer belonged to linear polyethylene with ultrahigh molecular weight and broad molecular weight distributions. This work demonstrated that MOFs containing coordinatively unsaturated metal sites might be a promising selective catalyst for ethylene slurry oligomerization. | |||
TO cite this article:HAN Yang,ZHANG Ying,LIU Suyan, et al. Selective Ethylene Oligomerization with Chromium-based Metal-Organic Framework MIL-100 Evacuated under Different Temperatures[OL].[ 8 October 2016] http://en.paper.edu.cn/en_releasepaper/content/4706439 |
3. Thermal regeneration of spent CeY sorbent used for thiophene adsorption from benzene | |||
LV longfei,LIAO Junjie,XIE Yuanyuan,FAN Lijun,CHANG Liping,BAO Weiren | |||
Chemical Engineering 05 August 2016 | |||
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Abstract:Benzene is an important chemical raw material, and coking benzene is one of its main resources, so the thiophene impurity should be deeply removed. The CeY adsorbent prepared by NaY zeolite ion-exchanging by cerium ion has been reported an excellent adsorption desulfurization ability. Thus it is necessary to investigate its regeneration behavior. In this paper, the spent CeY sorbent adsorbing thiophene in benzene (TBY) was regenerated by thermal treatment under various conditions. The desulfurization efficiency of regenerated TBY samples was measured by static adsorption experiment. The results show that the regeneration temperature, regeneration time and oxygen content are the main influence factors for the regeneration of TBY samples. The regenerated performance of sorbent is mainly affected by sulfur and carbon content remained. The optimized regeneration condition is air atmosphere with the space velocity of 1000 h-1 at 500 oC for 1 h, and the corresponding desulfurization efficiency of regenerated TBY sample is over 96%. | |||
TO cite this article:LV longfei,LIAO Junjie,XIE Yuanyuan, et al. Thermal regeneration of spent CeY sorbent used for thiophene adsorption from benzene[OL].[ 5 August 2016] http://en.paper.edu.cn/en_releasepaper/content/4701982 |
4. Modeling of Liquid Phase Polymerization of Propylene in Loop Reactors | |||
Yaru Guo,Zhigang Lei,Chengna Dai,Zhanwei Liu,Jianwei Li | |||
Chemical Engineering 06 May 2016 | |||
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Abstract:In this paper, a rigorous mathematical model was developed to describe a new-type loop reactor for liquid phase polymerization of propylene since the loop reactor has more economic and technological advantages than conventional stirred tanks. The operation performance of the loop reactor was investigated in this work. The calculated results showed that at a high recycle ratio the distributions of concentrations of propylene, hydrogen and solid, as well as reaction temperature, are uniform along the axial direction of the loop reactor. This means that the loop reactor retains some characteristics of CSTR reactor. Analysis of multiple steady-state was made at different recycle ratio. At a high recycle ratio, three steady-state points were found. But when the heat transfer area decreased to 136 m2 or the cooling water temperature increases to 347 K, only one stable steady-state point would be found. However, at a low recycle ratio, the situation became a little complicated because the number of steady-state points was not always same along the axial direction of loop reactor. | |||
TO cite this article:Yaru Guo,Zhigang Lei,Chengna Dai, et al. Modeling of Liquid Phase Polymerization of Propylene in Loop Reactors[OL].[ 6 May 2016] http://en.paper.edu.cn/en_releasepaper/content/4686610 |
5. CFD simulations on hydrogenation of 2-ethylanthraquinone under Taylor flow in microchannels with and without chemical reaction | |||
Yaru Guo,Zhigang Lei,Chengna Dai | |||
Chemical Engineering 06 May 2016 | |||
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Abstract:The characteristics of mass transfer under Taylor flow with and without chemical reaction in circularmicrochannelswere investigated by Computational Fluid Dynamics (CFD) using the hydrogenation process of 2-ethylanthraquinone (EAQ) as a model reaction.The volumetric mass transfer coefficients in liquid phase (kLa) without chemical reaction were calculated for various parameters such as channel diameter, bubble rise velocity, unit cell length, and so on.The trend ofkLa with various parameters was obtained.The enhancement factor ofmass transferβ was introducedto quantitatively analyze mass transfer enhancement phenomenondue to the consumption of hydrogenunder chemical reaction. | |||
TO cite this article:Yaru Guo,Zhigang Lei,Chengna Dai. CFD simulations on hydrogenation of 2-ethylanthraquinone under Taylor flow in microchannels with and without chemical reaction[OL].[ 6 May 2016] http://en.paper.edu.cn/en_releasepaper/content/4686639 |
6. A Microneedle Mold Fabrication Method | |||
Guo Xin Dong,Wang Qi Lei | |||
Chemical Engineering 24 November 2015 | |||
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Abstract:Microneedle (MN) offers an attractive, painless and minimally invasive approach for transdermal drug delivery. Polymer microneedles are normally fabricated by using the micromolding method employing a MN mold, which is suitable for mass production due to high production efficiency and repeat-using of the mold. Most of the MN molds are prepared by pouring sylgard polymer over a MN master to make an inverse one after curing, which is limited in optimizing or controlling the MN structures and failing to keep the sharpness of MNs. In this work we describe a fabrication method of MN mold with controlled microstructures, which is meaningful for the fabrication of polymer MNs with different geometries. Laser micro-machining method was employed to drill on the surface of PDMS sheets to obtain MN molds. In the fabrication process, the microstructures of MN molds are precisely controlled by changing laser parameters and imported patterns. The MNs prepared from these molds are sharp enough to penetrate the skin. This scalable MN mold fabrication method is helpful for future applications of MNs. | |||
TO cite this article:Guo Xin Dong,Wang Qi Lei. A Microneedle Mold Fabrication Method[OL].[24 November 2015] http://en.paper.edu.cn/en_releasepaper/content/4664002 |
7. Preparation and Application of CMC-PVA/CS-PVA bipolar membranes modified by PAN-FePc (COOH)8 | |||
LI Zhonggui,CHEN Riyao | |||
Chemical Engineering 07 April 2015 | |||
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Abstract:In this paper, the polyacrylonitrile (PAN)-iron octocarboxyphthalocyanine (FePc(COOH)8) nanofibers were prepared using electrospinning technique and introduced into the interlayer of a carboxymethyl cellulose (CMC)-polyvinyl alcohol (PVA)/chitosan (CS)-polyvinyl alcohol bipolar membrane (BPM), which was characterized using SEM, contact angle measurement, current-voltage characteristics, AC impedance spectroscopy and so on. The experimental results showed that after modification by PAN-FePc(COOH)8 nanofibers, the membrane impedance of the BPM and its cell voltage were decreased. That indicated that the water splitting efficiency in the interlayer of the BPM was increased. Then the prepared CMC-PVA/PAN-FePc(COOH)8/CS-PVA BPM was used in the electro-oxidized preparation of dialdehydle starch (DAS). The experimental results indicated that a current density of 20mAocm-2 was suitable to obtain high current efficiency. When the electrolysis time was 3h at a current density of 20 mAocm-2 , the current efficiency of the CMC-PVA/PAN-FePc(COOH)8/CS-PVA BPM-equipped cell was as high as 67%. | |||
TO cite this article:LI Zhonggui,CHEN Riyao. Preparation and Application of CMC-PVA/CS-PVA bipolar membranes modified by PAN-FePc (COOH)8[OL].[ 7 April 2015] http://en.paper.edu.cn/en_releasepaper/content/4637992 |
8. Solid-liquid phase diagram for indomethacin-nicotinamide-methanol or methanol/ethyl acetate mixture and solubility behavior of 1:1 indomethacin-nicotinamide cocrystal at (298.15 and 313.15) K | |||
SUN Xiaowei,YIN Qiuxiang,XIE Chuang | |||
Chemical Engineering 19 December 2014 | |||
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Abstract:Solid-liquid equilibrium data for indomethacin (IMC) and nicotinamide (NCT) in both methanol (MeOH) and methanol/ethyl acetate (EA) mixture were measured using static method at (298.15 and 313.15) K under atmospheric pressure. 1:1 IMC-NCT cocrystal and IMCoMeOH was found in both systems under investigated conditions. The solubility of 1:1 IMC-NCT cocrystal was correlated using a mathematical model considering solution complexation. Solubility of IMC-NCT cocrystals as a function of co-former (NCT) concentration was evaluated. It's found that temperature has great effects on the formation of methanol solvate in the investigated systems. Solvate formation could be suppressed either by increasing temperature or using solvent mixtures. Additionally, solvent mixtures could level out the solubility differences between IMC and NCT, resulting in larger and more symmetric region for IMC-NCT cocrystal which would be helpful to the development of the 1:1 IMC-NCT cocrystallization process. | |||
TO cite this article:SUN Xiaowei,YIN Qiuxiang,XIE Chuang. Solid-liquid phase diagram for indomethacin-nicotinamide-methanol or methanol/ethyl acetate mixture and solubility behavior of 1:1 indomethacin-nicotinamide cocrystal at (298.15 and 313.15) K[OL].[19 December 2014] http://en.paper.edu.cn/en_releasepaper/content/4623875 |
9. Confined Synthesis of Silicalite-1 Hollow Spheres with a Lamellar Shell | |||
CHEN Huiyong | |||
Chemical Engineering 09 August 2014 | |||
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Abstract:A novel synthesis strategy with integrated using soft/hard templates was proposed for the confined synthesis of silicalite-1 hollow spheres with a lamellar shell. Replicated from macroporous carbon templates and directed by multi-quaternary ammonium surfactants, the silicalite-1 spheres demonstrated unique hollow nanoshell morphology, high crystallinity, and novel hierarchical porosity consisted of hollow macropores, interlamellar mesopores and ordered micropores in zeolites. | |||
TO cite this article:CHEN Huiyong. Confined Synthesis of Silicalite-1 Hollow Spheres with a Lamellar Shell[J]. |
10. Effect of the rare earth elements on the structure and catalytic oxidative desulfurization activities of phosphomolybdic acid loaded on silica | |||
QIU Jianghua,WANG Guanghui,WANG Ning | |||
Chemical Engineering 10 June 2014 | |||
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Abstract:The catalysts of phosphomolybdic acid loaded on silica and modified with La3+, Ce3+ and Pr3+ respectively were prepared by the sol-gel method and characterized by FT-IR, XRD and pore structure parameters analysis. The oxidative desulfurization of model fuel oil catalyzed by the catalysts have been studied under the mild condition. Results show that the catalysts kept integrity Keggin structures, the active centers of phosphomolybdic acid were greatly scattered and the pore size and specific surface area were increased obviously after modification. The catalytic oxidative reactions of dibenzothiophene (DBT) were accorded with the apparent first-order kinetics, and the apparent activation energies of DBT catalyzed by La-Mo/SiO2, Ce-Mo/SiO2 and Pr-Mo/SiO2 were 30.29 kJ/mol, 33.41 kJ/mol and 35.15 kJ/mol, respectively. | |||
TO cite this article:QIU Jianghua,WANG Guanghui,WANG Ning. Effect of the rare earth elements on the structure and catalytic oxidative desulfurization activities of phosphomolybdic acid loaded on silica[J]. |
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