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	1. Association Between Genetic Variants in pre-miRNA and Colorectal Cancer Risk in a Chinese Population
	Lv Meili,Dong Wei,Wei Yonggang,Li Lijuan,Zhang Lushun,Shu Xiaowei,Wang Li,Gao Linbo,Zhang Lin
	Basic Medicine 28 January 2013
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	Abstract:Background: Single nucleotide polymorphisms (SNPs) in pre-miRNAs may alter microRNA expression levels or processing and then contribute to the susceptibility of cancer development. We hypothesized that SNPs in pre-miRNAs may be association associated with the risk of colorectal cancer (CRC). Methods: We used genotyped four common polymorphisms (i.e., rs11614913, rs3746444, rs2910164, and rs2292832) in pre-miRNAs of 353 CRC patients and 540 healthy controls to investigate the association between the SNPs and the risk of CRC using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) genotyped four common polymorphisms(rs11614913, rs3746444, rs2292832 and rs2910164) in pre-miRNAs of 353 CRC patients and 540 healthy controls to investigate the association between them and the risk of CRC assay..Results: The rs11614913 CT, TT genotypes and T allele were associated with an increased risk of CRC compared with the CC genotype and C allele (CT vs. CC: OR＝7.34, 95% CI, 3.76-14.34; TT vs. CC: OR＝13.66, 95% CI, 6.76-27.6; T vs. C: OR＝1.99, 95% CI, 1.63-2.42, respectively). Interestingly, using the rs2910164 GG genotype as a reference, the rs2910164 GC genotype was associated with an increased risk of CRC (OR＝1.49, 95% CI, 1.02-2.18), whereas the rs2910164 CC genotype was associated with a decreased risk of CRC (OR＝0.58, 95% CI, 0.37-0.93). When compared with the rs2910164G allele, rs2910164 C allele was associated with a reduced risk of CRC (OR＝0.80, 95% CI, 0.66-0.97, P=0.02). significantly increased CRC risk were found to be associated with CT genotype (OR＝0.136, 95% CI: 0.070-0.266) and TT genotype (OR＝0.073, 95% CI: 0.036-0.148) vs. CC genotype of rs11614913, CT (OR＝0.166, 95% CI: 0.037-0.735,) and TT genotype (OR＝0.167, 95% CI: 0.038-0.729) vs. CC genotype of rs3746444, and GC genotype (OR＝0.670, 95% CI: 0.460-0.977) vs. GG genotype of rs2910164. Unfortunately, there were no statistically significant differences between cases and controls in genotype of rs2292832. When compared with the alleles, significantly increased CRC risk were found to be associated with T allele (OR＝0. 530, 95% CI: 0.413-0.613) vs. C allele in rs11614913. There were no statistically significant differences between cases and controls in alleles of rs3746444, rs2292832 and rs2910164.Conculsion: These findings suggest that rs11614913 and rs2910164 polymorphisms may be associated with the etiology of CRC.
	TO cite this article:Lv Meili,Dong Wei,Wei Yonggang, et al. Association Between Genetic Variants in pre-miRNA and Colorectal Cancer Risk in a Chinese Population[OL].[28 January 2013] http://en.paper.edu.cn/en_releasepaper/content/4517990


	2. Influences of Angiotensin I-Converting Enzyme and Endothelial Nitric Oxide Synthase Gene Polymorphisms on Hepatocellular Carcinoma Risks in China
	YUAN Fang,ZHANG Lushun,LI Hongyu,LIAO Miao,LV Meili※,ZHANG Chongjie※
	Basic Medicine 11 January 2013
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	Abstract:Aims: Growing evidences suggested that angiotensin-converting enzyme (ACE) gene and endothelial nitric oxide synthase (eNOS) gene have been associated with the risk in a wide range of cancers. The objective of this study was to examine whether two DNA polymorphisms at the ACE insertion/deletion (I/D) and NOS intron 4 variable number of tandem repeats (4a/4b) have been linked with the risk of developing hepatocellular carcinoma (HCC) in a Chinese population. Methods: Polymorphisms of ACE I/D and eNOS 4a/4b were genotyped in 293 HCC patients and 384 healthy control subjects using the polymerase chain reaction (PCR). Results: Frequencies of D allele and DD genotype in ACE gene of HCC patients were significantly different from that in healthy controls. However, no differences were observed in eNOS 4a/4b genotype and allele frequencies between the HCC and controls. Conclusions: These findings indicate that the ACE I/D polymorphism may play a role in HCC progression.
	TO cite this article:YUAN Fang,ZHANG Lushun,LI Hongyu, et al. Influences of Angiotensin I-Converting Enzyme and Endothelial Nitric Oxide Synthase Gene Polymorphisms on Hepatocellular Carcinoma Risks in China[OL].[11 January 2013] http://en.paper.edu.cn/en_releasepaper/content/4511647


	3. Data analysis of HLA-A*0201 bound peptide nonamers in PDB
	Zhang Ruxiang,Huang Qinghai,Zhang Jianqiong,Xie Wei
	Basic Medicine 18 May 2006
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	Abstract:HLA structural data were downloaded from PDB. All data were filtered by programming and were managed in the Visual FoxPro (VFP). With Biopolymer module of InsigtII software, hydrogen atoms were added to filtered molecules. Then, the program was utilized to analyze distances of every two Cα atoms of peptide nonamers and amino acid residues of HLA involved within a different distance around 26 peptide nonamers respectively. There were 26 HLA-A0201 complexes with peptide nonamers in PDB. The position 2(P2) of 21 peptides was Leu. Meanwhile, P9 was either Leu or Val mostly (25/26). The mean number of H-bond between P1 and molecule HLA-A0201 was 1.86, while those at P2 and P9 were 1.81, 1.95 respectively. By method of moment, some distances of two Cα atoms appeared normal school. Some amino acid residues of HLA, such as Tyr7, Glu63, Lys66, His70, Thr73, Ser77, Leu81, Tyr99, Thr143, Trp147 and Tyr171, appeared above 90% within a distance of 0.25 nm around peptide nonamers. P1 maybe is anchoring residue, just like P2 and P9. Distances of two Cα atoms of peptide nonamers can be utilized to check whether the structure of peptide is reasonable after molecular docking. Some high frequency residues can be applied to adjust binding subset for docking
	TO cite this article:Zhang Ruxiang,Huang Qinghai,Zhang Jianqiong, et al. Data analysis of HLA-A*0201 bound peptide nonamers in PDB[OL].[18 May 2006] http://en.paper.edu.cn/en_releasepaper/content/6680

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