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1. A novel relationship for schizophrenia, bipolar and major depressive disorder: a hint from chromosome 2 high density association screen | |||
Xing Chen,Feng Long,Bin Cai,Xiaohong Chen,Gang Chen | |||
Clinical Medicine 14 May 2015 | |||
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Abstract:Background :Convergent evidence from genetics, symptology and psychopharmacology imply that there are some intrinsic connection betweem schizophrenia (SCZ) , bipolar disorder (BPD) and major depressive disorder (MDD). Also, any two or even three of these disorder could co-existe in some families. Methods: A total of 47,103 SNPs on chromosome 2 were genotyped by Affymetrix Genome-Wide Human SNP array 6.0 on 119 SCZ, 253 BPD (type-Ⅰ) , 177 MDD, and 1000 controls. Results:Associated loci were comprehensively revealed and outstanding susceptibility genes were identified including ACVR1, BCL11A, CNTNAP5, CRIM1, DNER, DTNB, ERBB4, FSHR, IKZF2, LRP1B, LRRTM4, LYPD6B, MYO3B, NOL10, NPAS2, NRXN1, PARD3B, PID1, PKP4, PLCL1, SPAG16, SPTBN1, THADA, TRPM8, UPP2 and ZNF385B. Unexpectedly, flanking genes for up to 98.3 % of associated SNPs were replicated ( P ≦9.9 x 10 -8 ) in an enlarged cohort of 986 SCZ cases. Conclusions :Bipolar disorder and major depressive disorder are subtypes of schizophrenia. | |||
TO cite this article:Xing Chen,Feng Long,Bin Cai, et al. A novel relationship for schizophrenia, bipolar and major depressive disorder: a hint from chromosome 2 high density association screen [OL].[14 May 2015] http://en.paper.edu.cn/en_releasepaper/content/4643029 |
2. How does emotional context modulate response inhibition in alexithymia:electrophysiological evidence from an ERP study | |||
ZHANG Lei,YE Rong,YU Fengqiong,CAO Zhaolun,ZHU Chunyan,CAI Zhu,HU Panpan,PU Hui,WANG Kai | |||
Clinical Medicine 18 October 2012 | |||
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Abstract:Background Alexithymia, characterized by difficulties in identifying and describing feelings, is highly indicative of a broad range of psychiatric disorders. Several studies have also discovered the response inhibition ability impairment in alexithymia. However, few studies on alexithymic individuals have specifically examined how emotional context modulates response inhibition procedure. In order to investigate emotion cognition interaction in alexithymia, we analyzed the spatiao-temporal features of such emotional response inhibition by the approaches of event-related potentials and neural source-localization. Method The study participants included 15 subjects with high alexithymia scores on the 20-item Toronto Alexithymia Scale (alexithymic group) and 15 matched subjects with low alexithymia scores (control group). Subjects were instructed to perform a modified emotional Go/Nogo task while their continuous electroencephalography activities were synchronously recorded. The task includes 3 categories of emotional contexts (positive, negative and neutral) and 2 letters ("M" and "W") centered in the screen. Participants were told to complete go and nogo actions based on the letters. We tested the influence of alexithymia in this emotional Go/Nogo task both in behavioral level and related neural activities of N2 and P3 ERP components. Results We found that negatively valenced context elicited larger central P3 amplitudes of the Nogo-Go difference wave in the alexithymic group than in the control group. Furthermore, source-localization analyses implicated the anterior cingulate cortex (ACC) as the neural generator of the Nogo-P3. Conclusion These findings suggest that difficulties in identifying feelings, particularly in negative emotions, is a major feature of alexithymia, and the ACC plays a critical role in emotion-modulated response inhibition related to alexithymia. | |||
TO cite this article:ZHANG Lei,YE Rong,YU Fengqiong, et al. How does emotional context modulate response inhibition in alexithymia:electrophysiological evidence from an ERP study[OL].[18 October 2012] http://en.paper.edu.cn/en_releasepaper/content/4491798 |
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