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1. Changes of proteins induced by anticoagulants can be more sensitively detected in urine than in plasma | |||
Li Menglin,Zhao Mindi,Gao Youhe | |||
Biology 08 November 2013 | |||
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Abstract:Biomarker studies commonly monitor the composition of plasma, which is under strict homeostatic control, while urine is not. Urine is a partial filtrate of blood; however, its composition reflects systemic physiology. Here we show that changes in the coagulation status of blood can be more sensitively detected in urine than in plasma. Plasma and urine protein composition was analysed by LC-MS/MS and Western blot in six SD female rats before and after treatment with heparin or argatroban. LC-MS/MS and Western blot analyses demonstrated drug-induced increases in transferrin and hemopexin levels in urine but not in plasma. Our data indicates that urine may serve as a source for more sensitive detection of protein biomarkers than plasma. | |||
TO cite this article:Li Menglin,Zhao Mindi,Gao Youhe. Changes of proteins induced by anticoagulants can be more sensitively detected in urine than in plasma[J]. |
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