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Abstract:High tyrosine hydroxylase (TH) upstream-inhibited Rho GTPase activating protein 12 (ARHGAP12) molecular subnetwork was constructed, including upstream cytoplasmic FMR1 interacting protein 2 (CYFIP2), NCK adaptor protein 2 (NCK2), retinoblastoma binding protein 6 (RBBP6); downstream forkhead box N3 (FOXN3_2), SMAD family member 1 (SMAD1_2), sulfotransferase family 1A member 2 (SULT1A2) reported relation with learning in human left hemisphere. The common biology process of TH upstream-inhibited ARHGAP12 subnetwork was identified by DAVID, containing upstream CYFIP2, upstream NCK2, upstream RBBP6, downstream FOXN3_2, downstream SMAD1_2, downstream SULT1A2, first-core TH as protein binding; upstream CYFIP2, second-core ARHGAP12 as small GTPase mediated signal transduction; upstream CYFIP2, upstream NCK2 as vascular endothelial growth factor receptor signaling pathway; upstream NCK2, downstream SMAD1_2 as signal transduction, negative regulation of cell proliferation, positive regulation of transcription from RNA polymerase II promoter; upstream NCK2, second-core ARHGAP12 as positive regulation of GTPase activity; downstream FOXN3_2, downstream SMAD1_2 as transcription factor activity sequence specific DNA binding; downstream SULT1A2, first-core TH as small molecule metabolic process; The corresponding common cellular component of upstream CYFIP2, upstream NCK2, downstream SMAD1_2, downstream SULT1A2, second-core ARHGAP12, first-core TH as cytosol; upstream CYFIP2, upstream NCK2, upstream RBBP6, downstream SMAD1_2, first-core TH as cytoplasm. The corresponding common tissue distributions as CD8+T cells_3rd, PLACENTA_3rd maybe exist the same pattern with human left hemisphere. We propose and mutual positively verify tyrosine hydroxylase (TH) upstream-inhibited Rho GTPase activating protein 12 (ARHGAP12) subnetwork for learning in human left hemisphere|CD8+T cells|PLACENTA via cytosol positive regulation of transcription. |