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1. Tim-2 Up-regualtion and Galectin-9-Tim-3 Pathway Activation in Th2-Biased | |||
QI Yao,SONG Xiaorong,SHEN Jilong,XU Yuanhong,SHEN Qian,LUO Qingli,ZHONG Zhengrong,WANG Wei,CHU Deyong,SONG Wenjian | |||
Basic Medicine 07 March 2012 | |||
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Abstract:T cell immunoglobulin domain and mucin domain (Tim) family, a new gene that expresses on the surface of T cells, plays a critical role in regulation of T cells response. Previous data have shown that Tim-3 expressed on Th1 cells promotes itself apoptosis. Tim-2 is preferentially up-regulated during Th2 differentiation and functions as a potent costimulatory molecule for T-cell immunity. The present study aims to learn whether Tims proteins are responsible for Th2-biased response evoked by Schistosoma japonicum infection. The expressions of Tim-2 and Tim-3 in spleen lymphocytes from S. japonicum-infected mice were examined, and the possible role of galectin-9-Tim-3 pathway in Th2-biased response triggered by schistosome infection was discussed. Our results showed that schistosome infection could up-regulate Tim-2 which coincided with elevated IL-4 gene expression. Administration of galectin-9 significantly induced apoptosis of native spleen lymphocytes with down-regulation IFN-γexpression in vitro. Additionally, Tim-3-Fc fusion protein notably enhanced Th1 cells and decreased Th2 cells in vitro. Thus, we concluded that pro-apoptotic effects on Th1 population through galectin-9-Tim-3 pathway and the up-regulation of Tim-2 on Th2 cells might be critical to Th2-biased response of host with schistosomiasis japonica. | |||
TO cite this article:QI Yao,SONG Xiaorong,SHEN Jilong, et al. Tim-2 Up-regualtion and Galectin-9-Tim-3 Pathway Activation in Th2-Biased[OL].[ 7 March 2012] http://en.paper.edu.cn/en_releasepaper/content/4469018 |
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