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1. Asparagine linked glycosylation 8 alpha 13 glucosyltransferase homolog (S. cerevisiae) (ALG8) inhibited TGF beta receptor cognition mechanism | |||
HONG Tao,WANG Lin | |||
Basic Medicine 12 June 2022 | |||
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Abstract:Asparagine linked glycosylation 8 alpha 13 glucosyltransferase homolog (S. cerevisiae) (ALG8) feedback-inhibited beta-transducin repeat containing E3 ubiquitin protein ligase (BTRC) and ALG8 downstream-inhibited karyopherin subunit beta 1 (KPNB1) of TGF beta receptor knowledge and molecular subnetworks were constructed from ALG8 feedback-inhibited and downstream-inhibited networks based on integrating microarray significance analysis (SAM), SPSS correlation coefficient Pearson, gene (protein) reconstruction network (GRNInfer) and the Database for Annotation, Visualization and Integrated Discovery (DAVID). ALG8 feedback-inhibited BTRC of TGF beta receptor mechanism was identified upstream inositol 1 4 5-trisphosphate receptor type 1(ITPR1) of BM CD105+Endothelial_3rd, endoplasmic reticulum membrane, fetalbrain_3rd; microtubule associated protein 1B(MAP1B_2) of structural molecule activity; feedback calmodulin binding transcription activator 1(CAMTA1) of ovarian tumor_disease_3rd, ovary_normal_3rd; F-box and leucine-rich repeat protein 5(FBXL5) of protein ubiquitination, ubiquitin protein transferase activity; KIF3A of ATP binding; downstream C1D nuclear receptor corepressor(C1D) of ovarian tumor_disease_3rd, RNA binding; microtubule associated protein 1B(MAP1B_1) of structural molecule activity. ALG8 downstream-inhibited TGF beta receptor mechanism was identified upstream cyclin-dependent kinase 17(PCTK2) of ATP binding; feedback no result; downstream DAZ interacting zinc finger protein 3(DZIP3) of BM CD105+Endothelial_3rd, fetalbrain_3rd, ovarian tumor_disease_3rd, ovary_normal_3rd, ubiquitin protein transferase activity, RNA binding; iron-sulfur cluster assembly 1(ISCA1) of structural molecule activity; SEL1L ERAD E3 ligase adaptor subunit (SEL1L) of endoplasmic reticulum membrane; DDB1 and CUL4 associated factor 7(WDR68) of protein ubiquitination. We put forward ALG8 inhibited TGF beta receptor and cognition mechanism through activation of ATP binding or RE structural molecule or RNA binding or protein ubiquitination effect on fetalbrain, ovarian tumor_disease and normal, BM CD105+Endothelial. | |||
TO cite this article:HONG Tao,WANG Lin. Asparagine linked glycosylation 8 alpha 13 glucosyltransferase homolog (S. cerevisiae) (ALG8) inhibited TGF beta receptor cognition mechanism[OL].[12 June 2022] http://en.paper.edu.cn/en_releasepaper/content/4757972 |
2. Preparation of keratin/chitosan sponge and its application performance evaluation | |||
YAN Rongrong,SHI Jinsong | |||
Basic Medicine 13 May 2022 | |||
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Abstract:Uncontrolled bleeding leads to a higher fatality rate in the situation of surgery, traffic accidents and warfare. Traditional hemostatic materials such as bandages are not ideal for uncontrolled or incompressible bleeding. Therefore, it is of great significance to develop a new medical biomaterial with excellent rapid hemostatic effect. As a potential biomedical material, keratin has been developed and paid attention in tissue engineering fields such as promoting wound healing and nerve repair. Herein, a novel keratin/chitosan (K/C) sponge was prepared to achieve rapid hemostasis. The characterizations of K/C sponge were investigated, including SEM, TGA, liquid absorption and porosity, showing that the high porosity up to 90.12 ± 2.17% resulted in an excellent blood absorption. The cytotoxicity test and implantation experiment proved that the K/C sponge was biocompatible and biodegradable. Moreover, the prepared K/C sponge showed better hemostatic performance than chitosan sponge (CS) and the commercially available gelatin sponge in both rat tail amputation and liver trauma bleeding models. Further experiments showed that K/C sponge plays a hemostatic role through the endogenous coagulation pathway, thus shortening the activated partial thromboplastin time (APTT) effectively. Therefore, this study provided a novel K/C sponge which can be served as a promising biomedical hemostatic material. | |||
TO cite this article:YAN Rongrong,SHI Jinsong. Preparation of keratin/chitosan sponge and its application performance evaluation[OL].[13 May 2022] http://en.paper.edu.cn/en_releasepaper/content/4757746 |
3. Development of Fast Scanning Photoacoustic/Ultrasound Microscopy based on Parablic Mirror | |||
WU Ning,LI Changhui | |||
Basic Medicine 04 May 2017 | |||
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Abstract:We have developed a prototype fast scanning photoacoustic/ultrasound dual-modality microscopy, which provides the complementary information of optics and ultrasound imaging. Based on the design of optical parabolic mirror and water-immersible MEMS scanning mirror, the system achieves fast scanning property as well as confocal effect of collimated light and parallel ultrasound, to acquire a high resolution and simplified configuration. The feasibility of this system is demonstrated by the phantom experiment. The system shows strong potential for the pre-diagnosis of significant diseases. | |||
TO cite this article:WU Ning,LI Changhui. Development of Fast Scanning Photoacoustic/Ultrasound Microscopy based on Parablic Mirror[OL].[ 4 May 2017] http://en.paper.edu.cn/en_releasepaper/content/4732388 |
4. The Effects of Colonic Inner Environment on Microbial Fuel Cell Performance | |||
FU Yuming,Li Hongyan | |||
Basic Medicine 22 April 2017 | |||
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Abstract:Microbial fuel cells (MFCs) can produce electricity by utilizing the microorganisms and organic compounds in human large intestine, which might provide a new way for implantable medical devices (IMDs) to have a lasting, stable and safe power source. Our previous work showed that MFC could power IMDs under colonic inner environment of healthy people, but the effects of environmental changes caused by diseases on electricity generation of MFC remain unclear. Therefore, five continuous-flow double-chamber MFCs with simulated colonic content as anodic substrate were constructed and the performance changes under different intestinal peristalsis rates, colonic temperature and pH values were investigated accordingly in this study. The results indicated that most of the environmental changes which may happen during illnesses could lead to the decrease of electricity generation of MFC, except the increase of colonic temperature. However, all of the MFCs could still generate electricity of at least 1.71 mW which could fulfil the requirement of most IMDs. The performance of MFC with multi-factor environmental change simulating diarrhea and fever could maintain stable for about 4h, but with prolonged disease duration, the output voltage dropped dramatically. Generally, MFC has strong potential to be used as power source for IMDs, even under most ill conditions, but strategies should still be applied to improve the stability of output to avoid some extreme conditions. | |||
TO cite this article:FU Yuming,Li Hongyan. The Effects of Colonic Inner Environment on Microbial Fuel Cell Performance[OL].[22 April 2017] http://en.paper.edu.cn/en_releasepaper/content/4728103 |
5. 937nm Laser of Nd:GGG at the Absorption Peak of Vapor | |||
Wang Yufei,Liu Jingyu,Zhang Chunyu | |||
Basic Medicine 14 June 2016 | |||
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Abstract:In this paper we realized an efficient diode-pumped Nd-doped gadolinium gallium garnet (GGG) continuous-wave (CW) quasi-three-level laser operating at 937nm which is at the absorption peak of vapor. Laser actions of 0.5 at.% Nd-doped GGG crystals were also investigated. The maximum output power of 3 W was obtained at the incident pump power of 10.6 W with an optical to optical conversion efficiency of 29%. A maximum output power of 300 mW in the blue spectral range at 468 nm is achieved with 15-mm-long LBO. | |||
TO cite this article:Wang Yufei,Liu Jingyu,Zhang Chunyu. 937nm Laser of Nd:GGG at the Absorption Peak of Vapor[OL].[14 June 2016] http://en.paper.edu.cn/en_releasepaper/content/4696344 |
6. Simultaneous assay of platelet adhesion at multiple shear rates within a single microfluidic channel | |||
Zeng Lisha,Yang Jun | |||
Basic Medicine 01 April 2016 | |||
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Abstract:Cardiovascular diseases are currently the major causes of mortality in the world, especially in developed nations. As a predominant one, thrombosis is the platelet aggregation induced by a high shear rate. Platelet aggregation assay can clarify the occurrence mechanism of thrombosis, as well as used as an important tool in the clinical diagnosis, personalized treatment, and screening of anticoagulants. Thus, relevant studies attracted considerable attention. As an important step in platelet aggregation, platelet adhesion and its detection are also attracted intensive concern. Thus, some analytical methods have been developed for platelet adhesion assay, and the impact of shear rate is one of the focuses. Compared with other devices, biosensors can give a more accurate result within a shorter time. Furthermore, some biosensors can achieve real-time analysis. However, only one or several shear rates can be tested at the same time, which may decrease the analytical efficiency. Meanwhile, in most cases, only the average platelet-adhesion effect within a reactor is detection, and the impact of the distribution of shear rates is improperly neglected. In this study, a microfluidic device with a single channel is designed and fabricated for platelet adhesion assay. When the platelet-rich plasma flows through the collagen-modified sensing surface of the channel bottom, the interaction between platelets and collagen molecules on the entire surface can be simultaneously monitored by using a surface plasmon resonance imaging (SPRi) system. A gradient of the shear rate (0-546) could be formed within the channel by choosing a suitable depth-to-width ratio (1:5), so platelet adhesion at multiple shear rates could be monitored simultaneously. This method enables the measurement of the adhesion process of unlabeled platelets on the entire sensing surface, in vitro, at multiple shear rates. Such a system can obtain more accurate platelet adhesion result at a given shear rate than traditional methods. Furthermore, in an individual operation, platelet adhesion can be repeatedly tested at multiple points with an equal shear rate, so a much higher analytical efficiency can also be achieved. | |||
TO cite this article:Zeng Lisha,Yang Jun. Simultaneous assay of platelet adhesion at multiple shear rates within a single microfluidic channel[OL].[ 1 April 2016] http://en.paper.edu.cn/en_releasepaper/content/4682815 |
7. Nanomaterials in Bone Regeneration | |||
TIAN Taoran,CAI Xiaoxiao | |||
Basic Medicine 05 December 2015 | |||
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Abstract:Regenerative medicine is gathering more and more interests as it circumvents limitations and imperfections of traditional graft therapies such as autograft and xenograft. As for the part and parcel of regenerative medicine, the prosperous development in material science boost reciprocal approaches in bone regeneration. Nowadays, the refinement of materials leads our sights into a scale of nano. Nanomaterials, owing to their unique biomimic properties and unsurpassed surface merits, brought profound innovations to various fields, including bone tissue engineering. Studies have been designed to reveal interactions between bone tissues and nanomaterials, and thereby explore the potential applications in the same front. In this review, we summarized recent literatures, coming up with the basic characteristics of nanomaterials and their superiorities to traditional materials, and following with their unique features and applications in the process of bone regeneration. By the comparison and analyzing, we hope to purpose a comprehensive understanding over nanomaterials applied in bone regeneration. | |||
TO cite this article:TIAN Taoran,CAI Xiaoxiao. Nanomaterials in Bone Regeneration[OL].[ 5 December 2015] http://en.paper.edu.cn/en_releasepaper/content/4669279 |
8. Markers in diagnosis of lung cancer: Several common detection methods | |||
LIN Liquan,ZHANG Xi,ZOU Yingchang,LU Yanli,WANG Ping,CHEN Xing | |||
Basic Medicine 09 September 2015 | |||
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Abstract:There's an old saying in China that people turn pale at the mention of a tiger. Today, people will turn pale at the mention of lung cancer because of its high morbidity and high mortality. Fortunately, studies have found lots of markers that can be applied in observational and analytic epidemiology, randomized clinical trials, screening, diagnosis and prognosis of lung cancer. Those markers are including proteins in serum, volatile organic compounds (VOCs) in exhaled breath, exhaled breath condensates (EBCs), gene expression, microRNAs, and medical imaging indices. At the same time, various detection techniques were used to measure the markers. With the effort of researchers, a better detection of lung cancer will be realized by combining different markers in different stages. Developing detection techniques will bring novel machines that are more rapid, more accurate, more robust and more comfort for the diagnosis of lung cancer patient. | |||
TO cite this article:LIN Liquan,ZHANG Xi,ZOU Yingchang, et al. Markers in diagnosis of lung cancer: Several common detection methods[OL].[ 9 September 2015] http://en.paper.edu.cn/en_releasepaper/content/4654285 |
9. Low SNR signal automatic quantification in magnetic resonance spectroscopy data | |||
LI Yao | |||
Basic Medicine 28 January 2015 | |||
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Abstract:The quantification of magnetic resonance spectroscopy (MRS) signals remains challenging due to the low signal-to-noise ratio (SNR) of data. Time-domain quantification methods highly require user interactions, which reduce the reproducibility of the data quantification results. The goal of our work is to design a systematic methodology for automated quantification of MRS signals with low SNRs. We used Hankel singular value decomposition (HSVD) algorithm in our signal estimation step, along with extraction and reduction filter (ER-filter) as a frequency selective technique in the preprocessing step in order to avoid the interferences from nuisance peaks. In the automatic model order selection problem of HSVD, we implemented three strategies based on reconstruction residue measurement or information theoretic criteria. The performances were evaluated in terms of detection rate and relative root mean squared error (RRMSE). The simulations were run on both synthesized and semi-synthesized data. We tested the strategies in two cases, i.e., without and with an interfering signal nearby the signal of interest. It is shown that the minimum description length with condition (MDLcon) based methodology we proposed performs the best and can obtain reliable estimation performance (RRMSE<40%) when signal SNR is larger than -18dB, with a detection rate above 72.44%. The performance is consistent when the interfering signal is 0.08ppm separated. Overall, the MDLcon based automated MRS signal quantification methodology provides an effective way for low SNR MRS signal estimation and detection. Our work may shed light on automatic MRS signal quantification in clinical applications when the corresponding metabolite concentration is low. | |||
TO cite this article:LI Yao. Low SNR signal automatic quantification in magnetic resonance spectroscopy data[OL].[28 January 2015] http://en.paper.edu.cn/en_releasepaper/content/4631195 |
10. Brain Activation Study during Stroke Recovery Using BOLD-fMRI | |||
LI Yao | |||
Basic Medicine 28 January 2015 | |||
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Abstract:Stroke recovery involves a battery of plastic changes in the brain. Blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) technology provides brain activation information with exquisite spatial resolution as a powerful tool for investigating changes in brain plasticity. In this paper, we performed a longitudinal study examining plasticity of functional activation as exhibited by BOLD-fMRI following stroke. Data were collected from 11 patients with corticospinal tract (CST) damage at three stages of recovery, i.e., acute stage (<2wks), early stage (1mon-3mons) and chronic stage (>3mons) post stroke. The evolution of cortical activations for both affected and unaffected hand motion tasks were studied. Quantitative activation measurements including the effective size and sum of t values were calculated and the correlations of these values with patient Fugl-Meyer index were analyzed across all stages. Stroke patients showed a shift from bilateral activation in acute and early stage to the ipsilesional activation in chronic stage when performing a movement task with the affected hand, which suggests a compensation effect from the contralesional hemisphere during the recovery process. The correlation analysis showed a significantly negative correlation with cingulate cortex activity at early stage from both quantitative activation measurements, implying the important role of cingulate cortex in stroke recovery. Further investigations are in need to improve the understanding of functional recovery in stroke patients. | |||
TO cite this article:LI Yao. Brain Activation Study during Stroke Recovery Using BOLD-fMRI[OL].[28 January 2015] http://en.paper.edu.cn/en_releasepaper/content/4631071 |
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