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1. Asparagine linked glycosylation 8 alpha 13 glucosyltransferase homolog (S. cerevisiae) (ALG8) inhibited TGF beta receptor cognition mechanism | |||
HONG Tao,WANG Lin | |||
Basic Medicine 12 June 2022 | |||
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Abstract:Asparagine linked glycosylation 8 alpha 13 glucosyltransferase homolog (S. cerevisiae) (ALG8) feedback-inhibited beta-transducin repeat containing E3 ubiquitin protein ligase (BTRC) and ALG8 downstream-inhibited karyopherin subunit beta 1 (KPNB1) of TGF beta receptor knowledge and molecular subnetworks were constructed from ALG8 feedback-inhibited and downstream-inhibited networks based on integrating microarray significance analysis (SAM), SPSS correlation coefficient Pearson, gene (protein) reconstruction network (GRNInfer) and the Database for Annotation, Visualization and Integrated Discovery (DAVID). ALG8 feedback-inhibited BTRC of TGF beta receptor mechanism was identified upstream inositol 1 4 5-trisphosphate receptor type 1(ITPR1) of BM CD105+Endothelial_3rd, endoplasmic reticulum membrane, fetalbrain_3rd; microtubule associated protein 1B(MAP1B_2) of structural molecule activity; feedback calmodulin binding transcription activator 1(CAMTA1) of ovarian tumor_disease_3rd, ovary_normal_3rd; F-box and leucine-rich repeat protein 5(FBXL5) of protein ubiquitination, ubiquitin protein transferase activity; KIF3A of ATP binding; downstream C1D nuclear receptor corepressor(C1D) of ovarian tumor_disease_3rd, RNA binding; microtubule associated protein 1B(MAP1B_1) of structural molecule activity. ALG8 downstream-inhibited TGF beta receptor mechanism was identified upstream cyclin-dependent kinase 17(PCTK2) of ATP binding; feedback no result; downstream DAZ interacting zinc finger protein 3(DZIP3) of BM CD105+Endothelial_3rd, fetalbrain_3rd, ovarian tumor_disease_3rd, ovary_normal_3rd, ubiquitin protein transferase activity, RNA binding; iron-sulfur cluster assembly 1(ISCA1) of structural molecule activity; SEL1L ERAD E3 ligase adaptor subunit (SEL1L) of endoplasmic reticulum membrane; DDB1 and CUL4 associated factor 7(WDR68) of protein ubiquitination. We put forward ALG8 inhibited TGF beta receptor and cognition mechanism through activation of ATP binding or RE structural molecule or RNA binding or protein ubiquitination effect on fetalbrain, ovarian tumor_disease and normal, BM CD105+Endothelial. | |||
TO cite this article:HONG Tao,WANG Lin. Asparagine linked glycosylation 8 alpha 13 glucosyltransferase homolog (S. cerevisiae) (ALG8) inhibited TGF beta receptor cognition mechanism[OL].[12 June 2022] http://en.paper.edu.cn/en_releasepaper/content/4757972 |
2. Preparation of keratin/chitosan sponge and its application performance evaluation | |||
YAN Rongrong,SHI Jinsong | |||
Basic Medicine 13 May 2022 | |||
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Abstract:Uncontrolled bleeding leads to a higher fatality rate in the situation of surgery, traffic accidents and warfare. Traditional hemostatic materials such as bandages are not ideal for uncontrolled or incompressible bleeding. Therefore, it is of great significance to develop a new medical biomaterial with excellent rapid hemostatic effect. As a potential biomedical material, keratin has been developed and paid attention in tissue engineering fields such as promoting wound healing and nerve repair. Herein, a novel keratin/chitosan (K/C) sponge was prepared to achieve rapid hemostasis. The characterizations of K/C sponge were investigated, including SEM, TGA, liquid absorption and porosity, showing that the high porosity up to 90.12 ± 2.17% resulted in an excellent blood absorption. The cytotoxicity test and implantation experiment proved that the K/C sponge was biocompatible and biodegradable. Moreover, the prepared K/C sponge showed better hemostatic performance than chitosan sponge (CS) and the commercially available gelatin sponge in both rat tail amputation and liver trauma bleeding models. Further experiments showed that K/C sponge plays a hemostatic role through the endogenous coagulation pathway, thus shortening the activated partial thromboplastin time (APTT) effectively. Therefore, this study provided a novel K/C sponge which can be served as a promising biomedical hemostatic material. | |||
TO cite this article:YAN Rongrong,SHI Jinsong. Preparation of keratin/chitosan sponge and its application performance evaluation[OL].[13 May 2022] http://en.paper.edu.cn/en_releasepaper/content/4757746 |
3. The Effects of Colonic Inner Environment on Microbial Fuel Cell Performance | |||
FU Yuming,Li Hongyan | |||
Basic Medicine 22 April 2017 | |||
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Abstract:Microbial fuel cells (MFCs) can produce electricity by utilizing the microorganisms and organic compounds in human large intestine, which might provide a new way for implantable medical devices (IMDs) to have a lasting, stable and safe power source. Our previous work showed that MFC could power IMDs under colonic inner environment of healthy people, but the effects of environmental changes caused by diseases on electricity generation of MFC remain unclear. Therefore, five continuous-flow double-chamber MFCs with simulated colonic content as anodic substrate were constructed and the performance changes under different intestinal peristalsis rates, colonic temperature and pH values were investigated accordingly in this study. The results indicated that most of the environmental changes which may happen during illnesses could lead to the decrease of electricity generation of MFC, except the increase of colonic temperature. However, all of the MFCs could still generate electricity of at least 1.71 mW which could fulfil the requirement of most IMDs. The performance of MFC with multi-factor environmental change simulating diarrhea and fever could maintain stable for about 4h, but with prolonged disease duration, the output voltage dropped dramatically. Generally, MFC has strong potential to be used as power source for IMDs, even under most ill conditions, but strategies should still be applied to improve the stability of output to avoid some extreme conditions. | |||
TO cite this article:FU Yuming,Li Hongyan. The Effects of Colonic Inner Environment on Microbial Fuel Cell Performance[OL].[22 April 2017] http://en.paper.edu.cn/en_releasepaper/content/4728103 |
4. 937nm Laser of Nd:GGG at the Absorption Peak of Vapor | |||
Wang Yufei,Liu Jingyu,Zhang Chunyu | |||
Basic Medicine 14 June 2016 | |||
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Abstract:In this paper we realized an efficient diode-pumped Nd-doped gadolinium gallium garnet (GGG) continuous-wave (CW) quasi-three-level laser operating at 937nm which is at the absorption peak of vapor. Laser actions of 0.5 at.% Nd-doped GGG crystals were also investigated. The maximum output power of 3 W was obtained at the incident pump power of 10.6 W with an optical to optical conversion efficiency of 29%. A maximum output power of 300 mW in the blue spectral range at 468 nm is achieved with 15-mm-long LBO. | |||
TO cite this article:Wang Yufei,Liu Jingyu,Zhang Chunyu. 937nm Laser of Nd:GGG at the Absorption Peak of Vapor[OL].[14 June 2016] http://en.paper.edu.cn/en_releasepaper/content/4696344 |
5. The Cell Uptake of Mesoporous Silica Nanoparticles Carrying DNA in Vitro | |||
SUN Yan,LIN Li,LIU Xianbin | |||
Basic Medicine 25 February 2013 | |||
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Abstract:The application of mesoporous silica nanoparticles (MSN) in gene carrying get more and more researchers' attention with its superior properties. In this paper, we researched the two kinds of cancer cell uptake of the MSNs that carried different DNA. The small molecule nucleic acid can successfully access into the interal pore of the nanoparticles with large quantitives, and the MSNs also play a good protection effect on the DNA absorbed. Interestingly, the more quantities DNA loaded the more MSNs were internalized by cancer cells. And compare with the uptake of the HeLa cells and HepG2 cells, the overall trend were similar except a little difference about the N-MSNs and the N-MSNs loaded low concentration DNA. In addition to this the cytotoxicity of the MSNs examined by MTT assay demonstrated that the MSNs possess good biocompatibility. So the MSNs can load large quantities small molecule nucleic acid and internalized by cancer cells efficiently. The findings provide a support for clinical research of gene therapy. | |||
TO cite this article:SUN Yan,LIN Li,LIU Xianbin. The Cell Uptake of Mesoporous Silica Nanoparticles Carrying DNA in Vitro[OL].[25 February 2013] http://en.paper.edu.cn/en_releasepaper/content/4523386 |
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