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1. Follow up in patients with allergic rhinitis discontinued immunotherapy within 1 year | |||
Zhu Xuewei | |||
Clinical Medicine 11 June 2016 | |||
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Abstract:BACKGROUND: Specific subcutaneous immunotherapy (SCIT) has shown good efficacy and tolerability in children and adolescents with allergic rhinitis (AR) in clinical studies. However, there was a high drop-out rate to SCIT in many parts of the world. Here, we investigate the reason of drop-out SCIT within one year and efficacy of SCIT after discontinuation among Chinese population. METHODS: 31 patients who started subcutaneous injections of standard dust mite vaccines from March 2006 to now and dropped out the treatment within one year were included in this study. Questionnaires for the reason of drop-out were investigated. SCIT efficacy was measured by VAS, symptom scores and medication scoring. Patients' qualities of life were also investigated. This study was followed up for one years post the final injections. RESULTS: All 31 patients gave the answers for the drop-out treatment. The reasons for discontinuation of SCIT were inability to visit hospital for the injections regularly (n=6, 19.4%), ineffectiveness (n=9, 29.0%), high cost (n=4, 12.9 %), improvement of allergic symptoms (n=11, 35.5%). Only one patient discontinued the SIT due to adverse events. Of 31 patients, 27 complete final assessment. The VAS, symptoms scores and medication score were all signi?cantly reduced, when were compared before and after SCIT, respectively. However, the degree of changes of these items ware not different, when comparing after SCIT and follow up post SCIT. CONCLUSION: Our study shows that inability to visit hospital for the injections regularly, ineffectiveness, high cost, and improvement of allergic symptoms may account for the drop-out rate of SCIT. Short course of SIT using injections of standard dust mite was shown to be effective but not sufficient. A prolonged treatment was recommended. | |||
TO cite this article:Zhu Xuewei. Follow up in patients with allergic rhinitis discontinued immunotherapy within 1 year[OL].[11 June 2016] http://en.paper.edu.cn/en_releasepaper/content/4697622 |
2. The role of Fascin-1 and E-cadherin expression in laryngeal squamous cell carcinoma | |||
ZOU Jian,YANG Hui,CHEN Fei,LI Wen,WANG Lihong,LIU Shixi | |||
Clinical Medicine 13 March 2013 | |||
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Abstract:Fascin-1 and E-cadherin which are related with cell motility and cell adhesiveness are important factors in the progression and metastasis of cancers. The objective of this study was to explore the association of Fascin-1 and E-cadherin expression level with clinical characteristics and prognosis of patients with laryngeal squamous cell carcinoma. In our study, tumor tissue samples from 150 patients with laryngeal squamous cell carcinoma were determined for Fascin-1 and E-cadherin expression by immunohistochemistry. The statistical analysis was performed to evaluate the association of Fascin-1 and E-cadherin expression with clinical characteristics and patient's prognosis. As a result, Fascin-1 expression was an independent predictive factors for recurrence in patients with laryngeal squamous cell carcinoma (P=0.021) and independently related to disease-free survival(P=0.010). Although E-cadherin expression status was not the independent predictive factors for recurrence (P=0.055) or disease-free survival (P=0.063), the subgroup with Fascin-1 high expression/E-cadherin low expression has the poorest prognosis (P=0.000) using subgroup analysis. In conclusion, Fascin-1 expression could be a potential prognostic predictor for patients with laryngeal squamous cell carcinoma. Simultaneous analysis of Fascin-1 and E-cadherin expression could be more effective to evaluate the prognosis of patients with laryngeal squamous cell carcinoma. | |||
TO cite this article:ZOU Jian,YANG Hui,CHEN Fei, et al. The role of Fascin-1 and E-cadherin expression in laryngeal squamous cell carcinoma[OL].[13 March 2013] http://en.paper.edu.cn/en_releasepaper/content/4529483 |
3. Clinical Outcomes of Endoscopic and Open Resection of Recurrent Sinonasal Inverted Papilloma | |||
GU Fengming | |||
Clinical Medicine 23 January 2011 | |||
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Abstract:Objective: To investigate the effectiveness of endoscopic surgery for recurrent sinonasal inverted papilloma and evaluate the recurrence rates of endoscopic and open resection at a single institution. Methods: Retrospective study was performed on 21 patients underwent operation in our department with histopathologically confirmed recurrent sinonasal inverted papilloma from January 1990 to January 2005. According to the Krouse staging system, the 21 recurrent cases were categorized into 1 case of Stage 1 (5%), 18 cases of Stage 2 (85%), 2 cases of Stage 3 (10%), and 0 case of Stage 4 (0%). There were 7 cases (33%) underwent endoscopic resection and 14 cases (67%) received open resection. Results: Of 21 recurrent patients who underwent resection, 4 patients (19%) were found to recur. The average time to recurrence was 28 months. The recurrence rates of patients with Stage 1, Stage 2 and Stage 3 were 0%, 17% and 50%, respectively (p<0.05). Recurrence was observed in 1 case (14%) in the endoscopic group and 3 cases (21%) in the open group (p>0.05). There was statistical difference in recurrence rates between Stage 1 and Stage 2 in endoscopic group (p<0.05) and between Stage 2 and Stage 3 in open group (p<0.05), respectively. There was no significant difference in recurrence rates between endoscopic and open group in comparable Stage 2 (p>0.05). Conclusion: Endoscopic and open approaches are both available to achieve radical excision of the recurrent sinonasal inverted papilloma with similar rates of recurrence. The risk of recurrence is likely related to the Krouse stage of the tumor, with more aggressive tumors having a higher propensity for recurrence. Endoscopic surgery is an effective treatment for recurrent sinonasal inverted papilloma. | |||
TO cite this article:GU Fengming. Clinical Outcomes of Endoscopic and Open Resection of Recurrent Sinonasal Inverted Papilloma[OL].[23 January 2011] http://en.paper.edu.cn/en_releasepaper/content/4408600 |
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