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1. Biofilm formation of an oral symbiotic bacteria and its effect on common oral pathogens | |||
Hui Wang,Zhanhai Yu,Zhiqiang Li,Jianye Zhou | |||
Clinical Medicine 20 October 2021 | |||
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Abstract:As a kind of symbiotic bacteria, Streptococcus sanguinis is widely distributed in the oral cavity, mainly including the surface of teeth, oral mucosa , and human saliva. Besides, as one of the initially colonized strains, Streptococcus sanguinis is the pioneer and key role in the development of oral biofilms, which is believed to resist pathogens and promote oral health. And the evolution of its biofilms plays an important part in both bacterial adaptations to the environment and invasion of the host. This paper discusses the early colonization mechanism of Streptococcus sanguinis and its interaction with pathogens related to caries and periodontitis, and finally, summarizes the methods of biofilm research, hoping to provide ideas for the follow-up research in this field. | |||
TO cite this article:Hui Wang,Zhanhai Yu,Zhiqiang Li, et al. Biofilm formation of an oral symbiotic bacteria and its effect on common oral pathogens[OL].[20 October 2021] http://en.paper.edu.cn/en_releasepaper/content/4755640 |
2. The role of sclerostin and receptor activator of nuclear factor κB ligand/osteoprotegerin signalling pathways in chronic periodontitis | |||
Wang Tiantian,Yuan Xuemin,Zhang Xingxing,LI Yue,Pang Yunqing,Wang Xuemei,Wang Jing | |||
Clinical Medicine 20 April 2018 | |||
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Abstract: Background: Chronic periodontitis are associated with the resorption of alveolar bone. Sclerostin participates in the process of bone resorption through the RANKL/RANK/OPG pathway. However, the mechanism of bone resorption and sclerostin expression in chronic periodontitis is unclear. In this study, the purpose was to evaluate the mechanism of action of sclerostin in human chronic periodontitis. Methods: Saliva and gingival crevicular fluid were collected from systemically healthy non-periodontitis (n=30) and chronic periodontitis subjects (n=30). The protein levels of sclerostin, RANKL and OPG in saliva and gingival crevicular fluid were detected by enzyme linked immunosorbent assay (ELISA). Results: Sclerostin levels in saliva and gingival crevicular fluid were significantly higher in the chronic periodontitis group than the non-periodontitis group (P < 0.05). The level of OPG is significantly lower but the RANKL level and the ratio of RANKL/OPG was significantly higher than that in the non-periodontitis group in saliva and gingival crevicular fluid (P < 0.05). Sclerostin levels in saliva and gingival crevicular fluid were significantly positively correlated with PD, CAL and BOP (P < 0.05). Conclusions: The results showed that sclerostin may affect bone tissue damage of chronic periodontitis through RANKL/RANK/OPG pathway. It will provide a new insight into the diagnosis and treatment of periodontitis patients. | |||
TO cite this article:Wang Tiantian,Yuan Xuemin,Zhang Xingxing, et al. The role of sclerostin and receptor activator of nuclear factor κB ligand/osteoprotegerin signalling pathways in chronic periodontitis[OL].[20 April 2018] http://en.paper.edu.cn/en_releasepaper/content/4744647 |
3. Synchronization of vascularization and neurotization may refine tissue-engineered bone | |||
Yan xiangzhen,Yang pishan | |||
Clinical Medicine 03 December 2008 | |||
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Abstract:Although the field of bone tissue engineering has progressed significantly in recent years, the development of structurally ordered tissues has not been accomplished. The major drawbacks of current tissue-engineered bones are disorganized matrix, defective mineralization, low clinical union rate as well as bone healing rate, weak mechanical stability and a reduced osteoblast population and activity. Available studies suggest that angiogenesis is closely associated with bone resorption and bone formation. Moreover, patients with neurological disorders exhibit localized osteopenia, bone fragility and increased fracture rate. It is obvious that the phenomena present in patients with neurological disorders almost coincide with those of tissue-engineered bone. And ongoing research in angiogenesis and neurogenesis has revealed many commonalities between these processes. Therefore, we hypothesize that there is a mutual promotion process between neurogenesis and angiogenesis, and the synchronization of vascularization and neurotization will provide a necessary solution to critical problems in bone tissue engineering. From a clinical standpoint, this hypothesis may throw new light in the treatment of patients with large segmental bone defects, numerous angiogenesis-dependent diseases as well as neurodegenerative diseases. | |||
TO cite this article:Yan xiangzhen,Yang pishan. Synchronization of vascularization and neurotization may refine tissue-engineered bone[OL].[ 3 December 2008] http://en.paper.edu.cn/en_releasepaper/content/26289 |
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