Authentication email has already been sent, please check your email box: and activate it as soon as possible.
You can login to My Profile and manage your email alerts.
If you haven’t received the email, please:
|
|
There are 13 papers published in subject: > since this site started. |
Select Subject |
Select/Unselect all | For Selected Papers |
Saved Papers
Please enter a name for this paper to be shown in your personalized Saved Papers list
|
1. Accurate Simulations and Analysis of Xinfadi COVID-19 Epidemics in Beijing | |||
Min Lequan | |||
Preventive Medicine and Hygienics 19 December 2020 | |||
Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
Abstract: To date, more than 71 millions on infected with COVID-19 have been identified worldwide. It causes more 1.6 millions deaths and affects more than 200 countries and regions. Establishing a mathematical model for epidemic infectious diseases has played an important role in the formulation, evaluation, and prevention of control strategies. The event of Xinfadi COVID-19 epidemic provides a successful example for prevent and control strategies and clinical treatments. This paper introduces a symptomatic-asymptomatic-recoverer differential equation model (SARDE). It gives the conditions of the stability on the disease-free equilibrium of SARDE. It proposes the necessary conditions of disease spreading. It determines the parameters of SARDE based on the reported data of Xinfadi COVID-19 epidemic and simulations. Numerical simulations of SARDE describe well the outcomes of current symptomatic individuals, current asymptomatic but infected individuals, recovered symptomatic infected individuals, and recovered asymptomatic but infected individuals. The numerical simulations suggest that both symptomatic and asymptomatic individuals cause lesser asymptomatic spread than symptomatic spread; blocking rate of 97% cannot prevent the spread of Xinfadi COVID19 epidemic; the strict prevention and control strategies implemented by Beijing government are not only very effective but also completely necessary. It is expected that the research results can provide new theoretical tools and ideas worthy of reference for better understanding and dominating of epidemic spreads, preventions and controls. | |||
TO cite this article:Min Lequan. Accurate Simulations and Analysis of Xinfadi COVID-19 Epidemics in Beijing[OL].[19 December 2020] http://en.paper.edu.cn/en_releasepaper/content/4753222 |
2. Simulations and Estimations of COVID-19 Epidemics in Beijing and Shanghai | |||
Min Lequan | |||
Preventive Medicine and Hygienics 27 July 2020 | |||
Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
Abstract:The 2019 novel coronavirus (COVID-19) is a new virus that causes respiratory illness in people. This virus was first identified during an investigation into an outbreak in December 2019 Wuhan, China. To date, more than 15 millions on infected with COVID-19 have been identified worldwide. It causes more 600,000 deaths and affects more than 200 countries and regions. Establishing a mathematical model for epidemic infectious diseases has played an important role in the formulation,evaluation,and prevention of control strategies.This paper introduces such a model (INSIAR). This model improves one our previous mathematical model: susceptible-infected- asymptomatic-recoverer (NSIAR), and provides a subsidiary model (SM). SM can decribe the evolotions of cuumulative died, recovered infected and recovered asymptomatic individuals. Consequently INSIAR can provide more clear and detailed interpretations to the dynamics of COVID-19 epidemic than those done by NSIAR. The solutions of INSIAR are all positive and bounded. NSIAR has a disease-free equilibrium and a disease-persistent equilibrium. It provides criterions of local stability, and conditions of globally asymptotical stability on the disease-free equilibrium. It gives criterions of epidemic spread. As applications, utilizing the reported data of COVID-19 epidemics in Beijing and Shanghai (form the first infections discoveries to about two weeks\' after infectious peak points) , this paper determines the model parameters with different periods, simualtes and estimates the outmomes of the COVID-19 epidemics in Beijing and Shanghai, and evaluate the prevention of control strategies in Beijing and Shanghai. Simulation results are close to some repoted clinic data of the COVID-19 in Beijing and Shanghail. If Beijing would take group imunity or loose imunity measures for COVID-19 epidemics. Simulation results showed that in both cases, there were about 230000 death cases, and the end date of the loose imunity was not earlier than that of the group imunity. However, If the authority and people in Beijing keep the current strict prevention and control measures, a few outside input COVID-19 infectious cases will not generate epidemic spreading. The analysis suggest that Beijing and Shanghai have similar infecting and spreading patterns of COVID-19 epidemics. Both cites have implemented almost the same prevent and control measures. It is expected that the research results can provide new theoretical tools and ideas worthy of reference for better understanding and dominating of epidemic spreads, preventions and controls. | |||
TO cite this article:Min Lequan. Simulations and Estimations of COVID-19 Epidemics in Beijing and Shanghai[OL].[27 July 2020] http://en.paper.edu.cn/en_releasepaper/content/4752590 |
3. Platelet parameters were associated with osteoporosis in large Chinese populations | |||
SUN Li-Li,LEI Shu-Feng | |||
Preventive Medicine and Hygienics 16 March 2020 | |||
Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
Abstract:Purpose Hematological changes related to osteoporosis in elder people are largely unknown. Our aim is to systemically evaluate associations between platelet parameters and osteoporosis in two large Chinese elder populations. Materials and Methods Subjects were selected from our ongoing cohort study: Osteoporosis Preventive Project (OPP), they were 982 from Shishan Community Health Center (Sample 1) and 3675 from Loujiang Community Health Center (Sample 2).The two hospitals used different models of instruments to detect platelet parameters, namely, Mindray BC-5800 automatic five-class blood cell analyzer and Mindray BC-2600 automatic three-class blood cell analyzer. Platelet parameters include platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT). BMD (g/cm2) was measured by dual-energy X-ray absorptiometry with Hologic densitometers (Hologic Inc., USA). We performed the Kruskal-Wallis rank test, Spearman correlation analysis and partial correlation analysis to detect the associations between the platelet parameters and BMD. Results Since most of basic characteristics of the two samples differed significantly (P<0.001), we separately analyzed the two samples. Among three groups categorized by LS BMD, PLT, PDW, and PCT were significantly different among the three groups. These results were consistent and replicated in the two samples (P<0.05). Similarly, significant differences only for PLT (P=0.003) and PCT (P=0.004) were observed in the Sample 2 among three groups categorized by FN BMD. The PLT and PCT were negatively correlated with LS BMD and FN BMD (P<0.01) in both samples when unadjusted, but after adjustment with sex, age and BMI, only two correlations were still significant (PLT and FN BMD, PCT and FN BMD in the Sample 2). Contrary to PLT and PCT, PDW was positively associated with LS BMD and FN BMD when unadjusted in both samples (P<0.01). However, the significantly positive correlations were only observed in the Sample 2 after adjustment. Conclusion The results suggest that three parameters (PLT, PDW and PCT) have significant correlations with BMD, but MPV has no associations with BMD. | |||
TO cite this article:SUN Li-Li,LEI Shu-Feng. Platelet parameters were associated with osteoporosis in large Chinese populations[OL].[16 March 2020] http://en.paper.edu.cn/en_releasepaper/content/4751215 |
4. Association between long noncoding RNAs expression levels and their gene polymorphisms with systemic lupus erythematosus | |||
Li Jun,Pan Haifeng,Ye Dongqing | |||
Preventive Medicine and Hygienics 25 April 2017 | |||
Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
Abstract:Increasing evidence has demonstrated the association between long noncoding RNAs (lncRNAs) and multiple autoimmune diseases. In this study, we explored four lncRNAs (GAS5, lnc-DC, linc0597 and linc0949) expression levels and gene polymorphisms in systemic lupus erythematosus (SLE). A two stage design was applied. 85 SLE patients and 71 healthy controls were enrolled to investigate the lncRNAs expression levelsin stages one. Then, 860 SLE patients and 831 healthy controls were included to detect the single nucleotide polymorphisms (SNPs) in the differentially expressed lncRNAs in stage two. Expression levels of lncRNAs were detected by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR). Genotyping was performed using the TaqMan SNP genotyping assays by an EP1 platform. The expression levels of linc0597, lnc-DC and GAS5 were significantly lower in SLE patients than healthy controls (Z=-5.984, P<0.001; Z=-3.703, P<0.001; Z=-2.995, P=0.003 respectively). No significant differences in linc0949 expression level was found between SLE patients and healthy controls (Z=-0.254, P=0.799). The expression levels of linc0597 was significantly decreased in lupus nephritis (LN) compared with SLE patients without nephritis (Z=-2.411, P=0.016). Moreover, the expression level of linc0597 was correlated with systemic lupus erythematosus disease activity. Four SNPs (rs10515177 for lnc-DC; rs2070107, rs2632516, rs2877877 for linc0597) with SLE risk were analyzed. Significant association was observed between the distribution of genotype (CC vs. GG) at SNP rs2070107 and susceptibility to SLE (OR=2.414, 95% CI: 1.266-4.601, P=0.007), and an increased risk was also found in the recessive model (CC vs. CG+GG) (OR=2.415, 95% CI: 1.271-4.590, P=0.007). Furthermore, linc0597 expression level may be associated with the dominant model (CC+CG vs GG) of rs2070107 in the exploration of 34 patients. The association between linc0597 SNPs and SLE as well as its altered expression and correlation with disease activity implicates an important role of this gene in the pathogenesis of SLE. | |||
TO cite this article:Li Jun,Pan Haifeng,Ye Dongqing. Association between long noncoding RNAs expression levels and their gene polymorphisms with systemic lupus erythematosus[OL].[25 April 2017] http://en.paper.edu.cn/en_releasepaper/content/4725288 |
5. Comprehensive long non-coding RNA expression profiling reveals their potential roles in systemic lupus erythematosus | |||
Li Lianju,Ye Dongqing | |||
Preventive Medicine and Hygienics 22 April 2017 | |||
Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
Abstract:long non-coding RNAs can regulate gene transcription, modulate protein function, and act as competing endogenous RNA. Yet, their roles in systemic lupus erythematosus remain to be elucidated. We determined the expression profiles of lncRNAs in T cells of SLE patients and healthy controls using microarrays. Up to 1935 lncRNAs and 1977 mRNAs were differentially expressed. QRT-PCR showed downregulated uc001ykl.1 (P=0.004) and ENST00000448942 (P=0.009) in SLE patients. Expression of uc001ykl.1 correlated with erythrocyte sedimentation rate and C-reactive protein, whereas ENST00000448942 level correlated with ESR and anti-Sm antibodies. Short time-series expression miner analysis revealed some lncRNAs whose expressions might correlate with disease activity of SLE patients. Coding-non-coding gene coexpression analyses showed differential lncRNAs might operate via modulating expressions of their correlated, relevant mRNAs in SLE. Differential lncRNAs might also function through their ceRNAs. Our study established that the aberrant expression profiles of lncRNAs may play a role in SLE and thus warrant further investigation. | |||
TO cite this article:Li Lianju,Ye Dongqing. Comprehensive long non-coding RNA expression profiling reveals their potential roles in systemic lupus erythematosus[OL].[22 April 2017] http://en.paper.edu.cn/en_releasepaper/content/4725270 |
6. the relationship of five NCDs and physical activity and sedentary behavior of Chinese adults | |||
WANG Wenbin,WEI Qing | |||
Preventive Medicine and Hygienics 15 June 2016 | |||
Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
Abstract:Objective Explore the relationship between the noncommunicable diseases(NCDs) and physical activity and sedentary in Chinese adults aged 18 to 55 years. Method Use the China Health and Nutrition Survey data, summary NCDs variables,physical activity variables and sedentary variables, then perform statistical analysis and cohort study. Result The relative risk of diabeta of respondents that exercise more than 280 MET a week is 0.32 (95% CI: 1.08 2.18). The relative risk of hypertension of respondents that sit between 14 and 28 hours during leisure time is 1.53 (95% CI: 1.08 2.18).The relative risk of diabeta of respondents that sit under 7 hours during leisure time is 2.41 (95% CI: 1.05 5.53). Conclusion Guarantee 40 MET physical activity every day and sit no more than 2 hours every day can reduce the risk of high blood pressure and diabetes. | |||
TO cite this article:WANG Wenbin,WEI Qing. the relationship of five NCDs and physical activity and sedentary behavior of Chinese adults[OL].[15 June 2016] http://en.paper.edu.cn/en_releasepaper/content/4697731 |
7. Increased intima-media thickness in rheumatoid arthritis: An update meta-analysis | |||
Peng Wang,Shi-Yang Guan,Shu-Zhen Xu,Hong-Miao Li,Rui-Xue Leng,Xiang-Pei Li,Hai-Feng Pan | |||
Preventive Medicine and Hygienics 18 November 2015 | |||
Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
Abstract:This study aims to derive a more precise estimation on carotid intima-media thickness (CIMT) level in patients with rheumatoid arthritis (RA) and related factors. Studies published from January 1 1982 to December 31 2014 in English, which comparing CIMT between RA group and control group were searched in PubMed, Embase and Cochrane Library database. Heterogeneity test was performed, and publication bias was evaluated. Stata software 12.0 was used to perform the Meta-analysis. 2163 articles were obtained after searching databases, and 46 studies were finally included in the meta-analysis. The result of analysis in random effect model showed that RA group had significantly higher CIMT than control group, with the SMD(standardized mean difference) of 1.07 and 95%CI (0.84,1.30). To evaluate the stability of our results, sensitivity analyses were performed, and the results showed no significant change when any one study was excluded. Subgroup analyses showed that region, race, age, BMI and disease duration were associated with CIMT in RA patients. In summary, CIMT in RA patients is thicker than healthy controls, and it is influenced by region, race, age, BMI and disease duration.(10 Points, Times New Roman) | |||
TO cite this article:Peng Wang,Shi-Yang Guan,Shu-Zhen Xu, et al. Increased intima-media thickness in rheumatoid arthritis: An update meta-analysis[OL].[18 November 2015] http://en.paper.edu.cn/en_releasepaper/content/4663104 |
8. A functional variant in MTRR intron-1 significantly increases risk of congenital heart disease in Han Chinese population | |||
ZHAO Jianyuan,YANG Xueyan,GU Zhuoya,WANG Jue,DUAN Wenyuan,YE Zhizhou,SHEN Hongbing,SHI Kaihu,HOU Jia,HUANG Guoying,JIN Li,QIAO Bing,WANG Hongyan | |||
Preventive Medicine and Hygienics 14 January 2013 | |||
Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
Abstract:Homocysteine is known to be an independent risk factor for congenital heart disease (CHD). Methionine synthase reductase (MTRR) is essential for adequate remethylation of homocysteine, which is the exclusively dominant pathway for homocysteine removal in earlier embryo development. Here we report the variant c.56+781 A>C (rs326119) in the intron-1 of MTRR significantly increases the CHD risk in Han Chinese population. In three independent case-control studies with a total of 2,340 CHD patients and 2,270 healthy control participants from different geographic areas, we observed that children carrying heterozygote AC and homozygote CC genotype have 1.40 fold (OR=1.40, 95% CI=1.23-1.59, P=2.32×10-7) and 1.84 fold (OR=1.84, 95% CI=1.54-2.20, P=2.3×10-11) increased risk for CHD than those carrying wild-type AA genotype, respectively. Both in vivo quantitative real-time PCR analysis of MTRR mRNA in cardiac tissue samples of CHD and in vitro luciferase assay in transfected cells showed that the c.56+781 C allele remarkably deceases MTRR transcription. Additionally, healthy individuals with homozygous CC genotype have significantly elevated plasma homocysteine level compared with the wild-type AA carriers. Thus, we demonstrated that MTRR c.56+781 A>C variant is an important genetic marker for the increased CHD risk through its down-regulation function on MTRR expression in the transcription stage. Our results accentuate the significance of functional SNP in non-coding region of homocysteine/folate metabolism pathway core genes for their potential contribution to the etiology of CHD. | |||
TO cite this article:ZHAO Jianyuan,YANG Xueyan,GU Zhuoya, et al. A functional variant in MTRR intron-1 significantly increases risk of congenital heart disease in Han Chinese population[J]. |
9. A Functional Variant in the Cystathionine b-Synthase Gene Promoter Significantly Reduces Congenital Heart Disease Susceptibility in a Han Chinese Population | |||
ZHAO Jianyuan,YANG Xueyan,SHI Kaihu,SUN Shuna,HOU Jia,WANG Jue,YE Zhizhou,DUAN Wenyuan,CHEN Yijiang,SHEN Hongbing,QIAO Bin,HUANG Guoying,JIN Li,WANG Hongyan | |||
Preventive Medicine and Hygienics 10 January 2013 | |||
Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
Abstract:Homocysteine is an independent risk factor for various cardiovascular diseases. There are two ways to remove homocysteine from embryonic cardiac cells: remethylation to form methionine or transsulfuration to form cysteine. Cystathionine β-synthase (CBS) catalyzes the first step of homocysteine transsulfuration as a rate-limiting enzyme. In this study, we identified a functional variant -4673C>G (rs2850144) in the CBS gene promoter region that significantly reduces the susceptibility to congenital heart disease (CHD) in a Han Chinese population consisting of 2,340 CHD patients and 2,270 controls. Individuals carrying the heterozygous CG and homozygous GG genotype had a 15% (OR=0.85, 95%CI=0.75-0.96, P=0.011) and 40% (OR=0.60, 95% CI=0.49-0.73, P=1.78×10-7) reduced risk to develop CHD than the wild-type CC genotype carriers in the combined samples, respectively. Additional stratified analyses demonstrated that CBS -4673C>G is significantly related to septation defects and conotruncal defects. In vivo detection of CBS mRNA levels in human cardiac tissues and in vitro luciferase assays consistently showed that the minor G allele significantly increased CBS transcription. A functional analysis revealed that both the attenuated transcription suppressor SP1 binding affinity and the CBS promoter hypomethylation specifically linked with the minor G allele contributed to the remarkably up-regulated CBS expression. Consequently, the carriers with genetically increased CBS expression would benefit from the protection due to the low homocysteine levels maintained by CBS in certain cells during the critical heart development stages. These results shed light on unexpected role of CBS and highlight the importance of homocysteine removal in cardiac development. | |||
TO cite this article:ZHAO Jianyuan,YANG Xueyan,SHI Kaihu, et al. A Functional Variant in the Cystathionine b-Synthase Gene Promoter Significantly Reduces Congenital Heart Disease Susceptibility in a Han Chinese Population[OL].[10 January 2013] http://en.paper.edu.cn/en_releasepaper/content/4512567 |
10. The serum pepsinogen II level is a better diagnostic marker in gastric cancer: a cross-sectional study in the Chinese population | |||
CAO Xueyuan,JIA Zhifang,JIN Meishan,JIANG Jing | |||
Preventive Medicine and Hygienics 19 December 2012 | |||
Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
Abstract:AIM: To investigate screening makers for gastric cancer, we assessed association between gastric cancer with serum pepsinogens in the study.( 19 words) METHODS: From 2008 to 2010, the subjects comprised of 450 patients with gastric cancer, 111 individuals with gastric atrophy, and 961 healthy controls were investigated in a cross section study in the Chinese population. Serum anti-Helicobacter pylori (H.pylori) IgG, pepsinogen (PG)I and PG II were detected by enzyme-linked immunosorbent assay methods (Biohit ELISA kit, Biohit, Helsinki, Finland). Gastric atrophy and gastric cancer were diagnosed by endoscopy and histopatholgical examinations. Odds ratio (ORs) and 95% confidence intervals (CIs) were calculated using a multivariate logistic regression. (82 words) RESULTS: Prevalence rate of H.pylori infection remains high in the Northeastern area of China. Rates of H.pylori IgG positive were greater in the gastric cancer and gastric atrophy groups compared to the control group (69.1%, 75.7% vs 49.7%, P<0.001). Higher level of PG II (15.9, 13.9 vs 11.5, P <0.001) and lower PGI /PGII ratio (5.4, 4.6 vs 8.4, P<0.001) were found in patients with either gastric cancer or gastric atrophy compared to healthy controls, whereas no correlation was found between the plasma PGI concentration and risk of gastric cancer (P=0.537). In addition, multivariate logistic analysis indicates that H.pylori infection and atrophic gastritis were independent risk factors for gastric cancer. Lower plasma PG I: II ratio is associated with higher risks of atrophy and gastric cancer. Furthermore, plasma PG II level significantly correlated with H. pylori-infected gastric cancer. (137 words) CONCLUSION: The serum PG II concentration and PGI/PGII ratio are potential biomarkers for H.pylori-infected gastric disease screening. PG II is independently associated with risk of gastric cancer. | |||
TO cite this article:CAO Xueyuan,JIA Zhifang,JIN Meishan, et al. The serum pepsinogen II level is a better diagnostic marker in gastric cancer: a cross-sectional study in the Chinese population[OL].[19 December 2012] http://en.paper.edu.cn/en_releasepaper/content/4505640 |
Select/Unselect all | For Selected Papers |
Saved Papers
Please enter a name for this paper to be shown in your personalized Saved Papers list
|
About Sciencepaper Online | Privacy Policy | Terms & Conditions | Contact Us
© 2003-2012 Sciencepaper Online. unless otherwise stated