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	1. A review on post-marketing quality and efficacy re-evaluation of Fufang Xueshuantong Capsule
	ZENG Xuan,ZHENG Yuying,LUO Jianwen,LIU Hong,SU Weiwei
	Traditional Chinese Medicine and Pharmacology 09 July 2020
	Show/Hide Abstract \| Cite this paper︱Full-text: PDF (607K B)

	Abstract:Fufang Xueshuantong Capsule (FXC) is a traditional Chinese medicine (TCM) formula composed of four herbs including Notoginseng Radix et Rhizoma, Astragali Radix, Salviae Miltiorrhizae Radix et Rhizoma, and Scrophularize Radix. Long-term, extensive clinical applications have confirmed that FXC could exert significant effects on fundus vascular diseases and stable angina pectoris. This review aims to systematically analyze and summarize the existing researches involving quality and efficacy re-evaluation of FXC, point out the typical problems, and further propose some opinions to contribute to future study. As a result, this review outlines the chemical profiles, quality control, pharmacokinetic and pharmacological properties of FXC based on reported results. Some problems are pointed out for FXC: the quality control needs further improvement, the pharmacokinetic properties have not been comprehensively investigated, and in-depth and systematic mechanism researches are scarce. Hereon we propose several directions for future study: (a) establishment of feasible HPLC or LC-MS based quantitative methods for simultaneous determination of multiple components to monitor the overall quality; (b) pharmacokinetic studies concerning humans, drug-drug interactions, and correlation with pharmacodynamics; (c) pharmacological mechanism researches integrating multi-omics technologies (gut microbiome, metabolomics, etc.).
	TO cite this article:ZENG Xuan,ZHENG Yuying,LUO Jianwen, et al. A review on post-marketing quality and efficacy re-evaluation of Fufang Xueshuantong Capsule[OL].[ 9 July 2020] http://en.paper.edu.cn/en_releasepaper/content/4752523


	2. Simultaneous extraction of baicalin and saccharides from Scutellariae Radix with aqueous two-phase system
	Yuan Xiaolin,Mu Xiaojing,Li Yan,Gou Yan,Tang Meiling,Xiao Shangyou
	Traditional Chinese Medicine and Pharmacology 27 April 2020
	Show/Hide Abstract \| Cite this paper︱Full-text: PDF (439K B)

	Abstract:Scutellariae Radix is a Chinese herb for detoxification. Efficient extraction of its main active components baicalin and saccharides is interesting to pharmaceutical and cosmetic fields. The baicalin and saccharides were efficiently extracted with aqueous two-phase systems (ATPSs) Ethanol-(NH4)2SO4-H2O (EtSO) and Ethanol-cosolvent-(NH4)2SO4-H2O (EtSO-cosolvent). The factors such as pH, (NH4)2SO4 concentration, ethanol fraction, cosolvent fraction, extraction time and temperature were optimized and thermodynamics for partition was discussed. With the extractions at 48 C for 40 min, the EtSO, EtSO-MtOH and EtSO-Acetone exhibited higher baicalin yield than conventional 70% ethanol system (v/v) by 21.4%, 24.8% and 26.2%, respectively; and they displayed saccharides yield in a similar level to that with water system. By dialysis method the saccharides extracted with ATPS was proved to have similar molecular weight to those extracted with water. Therefore, it is feasible to obtain two birds (two targets) with one stone (ATPS) in high efficiency.
	TO cite this article:Yuan Xiaolin,Mu Xiaojing,Li Yan, et al. Simultaneous extraction of baicalin and saccharides from Scutellariae Radix with aqueous two-phase system[OL].[27 April 2020] http://en.paper.edu.cn/en_releasepaper/content/4751820


	3. Application prospect of traditional Chinese medicine Exocarpium Citri grandis in the prevention and treatment of COVID-19
	Su Weiwei,Wang Yonggang,Li Peibo,Wu Hao,Zeng Xuan,Shi Rui,Zheng Yuying,Li Panlin,Peng Wei
	Traditional Chinese Medicine and Pharmacology 14 March 2020
	Show/Hide Abstract \| Cite this paper︱Full-text: PDF (198K B)

	Abstract:Exocarpium Citri grandis (ECG, called Huajuhong in Chinese) is traditional Chinese herbal medicine and has been used for the treatment of respiratory diseases for hundreds of years. Contained flavonoids have been documented to be the primary active components. Recently, ECG has been listed in a TCM formula in Guideline for the diagnosis and treatment of COVID-19 (Sixth Edition) in China. However, the efficacy and mechanism of ECG in the prevention and treatment of respiratory diseases have not been systematically reviewed. Hence, In this review, we summarized the efficacies of ECG and its pharmacologically active compound naringin in antitussive, expectorant, improving lung function, alleviating acute lung injury, attenuating pulmonary fibrosis, and enhancing antiviral immune response, so as to provide a reference for its clinical application.
	TO cite this article:Su Weiwei,Wang Yonggang,Li Peibo, et al. Application prospect of traditional Chinese medicine Exocarpium Citri grandis in the prevention and treatment of COVID-19[OL].[14 March 2020] http://en.paper.edu.cn/en_releasepaper/content/4751193


	4. Correlation between SmCPS1 promoter polymorphism and tanshinones contents in Salvia miltiorrhiza
	SUN Ying,CHEN Xin,GAN Xiaoyan,YAN Zhuyun,MU Dixiu,WANG Qingrong
	Traditional Chinese Medicine and Pharmacology 05 September 2017
	Show/Hide Abstract \| Cite this paper︱Full-text: PDF (517K B)

	Abstract:To investigate the relationship between SmCPS1 promoter polymorphism and the contents of tanshinones. We sequenced the SmCPS1 gene promoter region together with 388bp downstream from the translation start site and the content of tanshinones of 12 different germplasm of Salvia miltiorrhiza. To separate the functional polymorphic loci that may be related with the content of tanshinones from those not, the cis-elements of SmCPS1 promoter were predicted and analyzed by the Plant Transcriptional Regulatory Map database. We found 1) there was a different correlation between the polymorphism in the promoter region and the contents of the tanshinones. 2) Polymorphism on nine cis-elements, an 33bp insertion/deletion sequence and three tandem repeat variations in the sequence of SmCPS1 promoter may be related to the contents of tanshinones. These findings showed the relationships between SmCPS1 promoter polymorphism and tanshinones.
	TO cite this article:SUN Ying,CHEN Xin,GAN Xiaoyan, et al. Correlation between SmCPS1 promoter polymorphism and tanshinones contents in Salvia miltiorrhiza[OL].[ 5 September 2017] http://en.paper.edu.cn/en_releasepaper/content/4741360


	5. Pharmacokinetics of Terminalia Phenolics in Rats after Oral Administration of a Mongolian Compound Medicine Alatan-5
	Wu Dandan,Azzaya Jukov,Ma Chaomei
	Traditional Chinese Medicine and Pharmacology 04 May 2017
	Show/Hide Abstract \| Cite this paper︱Full-text: PDF (4K B)

	Abstract:This paper reports the pharmacokinetic properties of Terminalia phenolics after administration of Alatan-5 which is a compound Mongolian medicine containing the fruit of T. chebula in combination with four other medicines. Gallic acid, ellagic acid, casuarinin, and chebulic acid were detected and quantified in the rat plasma. Gallic acid showed

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