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	1. The synergistic anti-tumor effects of evodiamine based on animal model experiments: a systematic review and meta analysis
	Zheng He,Jiang Li,Pang yunqing,Lv Siyi,Lin Liqi,Wang Jing
	Traditional Chinese Medicine and Pharmacology 13 April 2022
	Show/Hide Abstract \| Cite this paper︱Full-text: PDF (0 B)

	Abstract:Evodiamine (EVO) is an alkaloid extracted from the dried and nearly ripe fruits of Euodia rutaecarpa used as an anti-cancer, anti-inflammatory and anti-obesity agent. However, robust evidence of preclinical experiments has been lacking so far. As a consequence, a systematic review and meta-analysis was conducted to assess the anti-tumor effect of evodiamine combined therapy. The search engine and electronic databases includes PubMed, Scopus, China Knowledge Resource Integrated Database (CNKI) and SinoMed. Stata 15.0 was used for data extraction. Tumor volume and tumor weight were evaluate at a 95% confidence level using random effects model. Begg\'s test and funnel plot were used for the evaluation of publication bias. Sensitivity analysis is used to investigate the stability of results.A total of 7 studies and 108 animals were included. Overall, EVO reduced tumor volume(SMD=-25.64,95% CI: -5.77 -3.13,I2=92.5%, P<0.05) and tumor weight(SMD=-8.91,95% CI: -16.37, -1.44,I2=94.1%, P<0.05). As a result, EVO combined therapy appears to be more effective compared with monotherapy. Moreover, EVO has a potential to alleviate the toxicity of chemotherapeutic agents, which increases the translatability to the clinical situation.
	TO cite this article:Zheng He,Jiang Li,Pang yunqing, et al. The synergistic anti-tumor effects of evodiamine based on animal model experiments: a systematic review and meta analysis[OL].[13 April 2022] http://en.paper.edu.cn/en_releasepaper/content/4757287


	2. A review on post-marketing quality and efficacy re-evaluation of Fufang Xueshuantong Capsule
	ZENG Xuan,ZHENG Yuying,LUO Jianwen,LIU Hong,SU Weiwei
	Traditional Chinese Medicine and Pharmacology 09 July 2020
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	Abstract:Fufang Xueshuantong Capsule (FXC) is a traditional Chinese medicine (TCM) formula composed of four herbs including Notoginseng Radix et Rhizoma, Astragali Radix, Salviae Miltiorrhizae Radix et Rhizoma, and Scrophularize Radix. Long-term, extensive clinical applications have confirmed that FXC could exert significant effects on fundus vascular diseases and stable angina pectoris. This review aims to systematically analyze and summarize the existing researches involving quality and efficacy re-evaluation of FXC, point out the typical problems, and further propose some opinions to contribute to future study. As a result, this review outlines the chemical profiles, quality control, pharmacokinetic and pharmacological properties of FXC based on reported results. Some problems are pointed out for FXC: the quality control needs further improvement, the pharmacokinetic properties have not been comprehensively investigated, and in-depth and systematic mechanism researches are scarce. Hereon we propose several directions for future study: (a) establishment of feasible HPLC or LC-MS based quantitative methods for simultaneous determination of multiple components to monitor the overall quality; (b) pharmacokinetic studies concerning humans, drug-drug interactions, and correlation with pharmacodynamics; (c) pharmacological mechanism researches integrating multi-omics technologies (gut microbiome, metabolomics, etc.).
	TO cite this article:ZENG Xuan,ZHENG Yuying,LUO Jianwen, et al. A review on post-marketing quality and efficacy re-evaluation of Fufang Xueshuantong Capsule[OL].[ 9 July 2020] http://en.paper.edu.cn/en_releasepaper/content/4752523


	3. Simultaneous extraction of baicalin and saccharides from Scutellariae Radix with aqueous two-phase system
	Yuan Xiaolin,Mu Xiaojing,Li Yan,Gou Yan,Tang Meiling,Xiao Shangyou
	Traditional Chinese Medicine and Pharmacology 27 April 2020
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	Abstract:Scutellariae Radix is a Chinese herb for detoxification. Efficient extraction of its main active components baicalin and saccharides is interesting to pharmaceutical and cosmetic fields. The baicalin and saccharides were efficiently extracted with aqueous two-phase systems (ATPSs) Ethanol-(NH4)2SO4-H2O (EtSO) and Ethanol-cosolvent-(NH4)2SO4-H2O (EtSO-cosolvent). The factors such as pH, (NH4)2SO4 concentration, ethanol fraction, cosolvent fraction, extraction time and temperature were optimized and thermodynamics for partition was discussed. With the extractions at 48 C for 40 min, the EtSO, EtSO-MtOH and EtSO-Acetone exhibited higher baicalin yield than conventional 70% ethanol system (v/v) by 21.4%, 24.8% and 26.2%, respectively; and they displayed saccharides yield in a similar level to that with water system. By dialysis method the saccharides extracted with ATPS was proved to have similar molecular weight to those extracted with water. Therefore, it is feasible to obtain two birds (two targets) with one stone (ATPS) in high efficiency.
	TO cite this article:Yuan Xiaolin,Mu Xiaojing,Li Yan, et al. Simultaneous extraction of baicalin and saccharides from Scutellariae Radix with aqueous two-phase system[OL].[27 April 2020] http://en.paper.edu.cn/en_releasepaper/content/4751820


	4. Application prospect of traditional Chinese medicine Exocarpium Citri grandis in the prevention and treatment of COVID-19
	Su Weiwei,Wang Yonggang,Li Peibo,Wu Hao,Zeng Xuan,Shi Rui,Zheng Yuying,Li Panlin,Peng Wei
	Traditional Chinese Medicine and Pharmacology 14 March 2020
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