Authentication email has already been sent, please check your email box: and activate it as soon as possible.
You can login to My Profile and manage your email alerts.
If you haven’t received the email, please:
|
|
There are 2 papers published in subject: > since this site started. |
Results per page: |
Select Subject |
Select/Unselect all | For Selected Papers |
Saved Papers
Please enter a name for this paper to be shown in your personalized Saved Papers list
|
1. Novel materials which possess the ability to target liver cells | |||
Chen Zhipeng,Xiao Lu,Cai Baochang | |||
Traditional Chinese Medicine and Pharmacology 26 April 2012 | |||
Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
Abstract:Introduction: Hepatic-targeted drug delivery systems are designed to treat diseases of the liver. However, since there are several different types of liver diseases that are caused by different cells, it is important to select the proper materials to target these different cells.Areas covered: This review addresses novel materials that possess the ability to target liver cells via receptor--ligand processes and offers an insight into the aspects of formulation design. It also discusses several approaches used to enhance the targeting efficiency of drug delivery systems to receptors in the liver cells. In addition, the delivery efficiency and therapeutic efficacy of these materials in the treatment of acute or chronic liver diseases is highlighted. Expert opinion: Further research into the use of clinical materials and the design ofsmartmaterials formulti-drug delivery todifferent organelles is important for future studies on these new materials. It is hoped that these targeted therapeutics will benefit patients with liver disorders in the near future. | |||
TO cite this article:Chen Zhipeng,Xiao Lu,Cai Baochang. Novel materials which possess the ability to target liver cells[OL].[26 April 2012] http://en.paper.edu.cn/en_releasepaper/content/4476385 |
2. The antidepressant-like effect of Cynanchum otophyllum | |||
YANG Qiongxiong,HUANG Xiao-yan | |||
Traditional Chinese Medicine and Pharmacology 17 August 2011 | |||
Show/Hide Abstract | Cite this paper︱Full-text: PDF (0 B) | |||
Abstract:In the course of screening for antidepressant from medicinal plants by the despair mice models, the total glycosides from Cynanchum otophyllum (TGCO) showed potent antidepressant effect by using fluoxetine as positive control. The mice were administered intragastrically with TGCO once a day for 5 days at doses of 10 mg/kg, 20mg/kg, 40mg/kg and 80mg/kg. Treating with TGCO significantly decreased the mice immobility time in tail suspension test (40, 80mg/kg, p<0.01) and in forced swim test (80mg/kg, p<0.01). Compared with blank control group, the treatment with TGCO decreased the traveled distance during test without statistical signi?cantly in the locomotor activity test. Treating mice with TGCO at the doses of 40 and 80 mg/kg significantly antagonized reserpine-induced ptosis and hypothermia, suggesting that the antidepressant effect of TGCO may be mediated via central monoaminergic neurotransmitter system. | |||
TO cite this article:YANG Qiongxiong,HUANG Xiao-yan. The antidepressant-like effect of Cynanchum otophyllum[OL].[17 August 2011] http://en.paper.edu.cn/en_releasepaper/content/4439358 |
Select/Unselect all | For Selected Papers |
Saved Papers
Please enter a name for this paper to be shown in your personalized Saved Papers list
|
Results per page: |
About Sciencepaper Online | Privacy Policy | Terms & Conditions | Contact Us
© 2003-2012 Sciencepaper Online. unless otherwise stated