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1. A review on post-marketing quality and efficacy re-evaluation of Fufang Xueshuantong Capsule | |||
ZENG Xuan,ZHENG Yuying,LUO Jianwen,LIU Hong,SU Weiwei | |||
Traditional Chinese Medicine and Pharmacology 09 July 2020 | |||
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Abstract:Fufang Xueshuantong Capsule (FXC) is a traditional Chinese medicine (TCM) formula composed of four herbs including Notoginseng Radix et Rhizoma, Astragali Radix, Salviae Miltiorrhizae Radix et Rhizoma, and Scrophularize Radix. Long-term, extensive clinical applications have confirmed that FXC could exert significant effects on fundus vascular diseases and stable angina pectoris. This review aims to systematically analyze and summarize the existing researches involving quality and efficacy re-evaluation of FXC, point out the typical problems, and further propose some opinions to contribute to future study. As a result, this review outlines the chemical profiles, quality control, pharmacokinetic and pharmacological properties of FXC based on reported results. Some problems are pointed out for FXC: the quality control needs further improvement, the pharmacokinetic properties have not been comprehensively investigated, and in-depth and systematic mechanism researches are scarce. Hereon we propose several directions for future study: (a) establishment of feasible HPLC or LC-MS based quantitative methods for simultaneous determination of multiple components to monitor the overall quality; (b) pharmacokinetic studies concerning humans, drug-drug interactions, and correlation with pharmacodynamics; (c) pharmacological mechanism researches integrating multi-omics technologies (gut microbiome, metabolomics, etc.). | |||
TO cite this article:ZENG Xuan,ZHENG Yuying,LUO Jianwen, et al. A review on post-marketing quality and efficacy re-evaluation of Fufang Xueshuantong Capsule[OL].[ 9 July 2020] http://en.paper.edu.cn/en_releasepaper/content/4752523 |
2. Fingerprint analysis of different Panax herbal species by HPLC-UV method | |||
Feng Zeng,Wang Xiaoming,Yang Min,Lu Zhiqiang,Guo Dean | |||
Traditional Chinese Medicine and Pharmacology 15 December 2007 | |||
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Abstract:To establish a method for distinguishing different commercial samples of Panax species including notoginseng, cultivated ginseng (Chinese ginseng and Korean ginseng), wild ginseng, red ginseng and three types of American ginsengs and one American ginseng preparation with their HPLC fingerprints, so as to assure the quality of different commercial samples of Panax species, HPLC-UV method was used to establish their fingerprints; Zorbax Extend C18 (250mm×4.6 mm , 5μm) was used as analytical column, and acetonitrile/ KH2PO4 aqueous solution was used as mobile phase with gradient elution. The resultes showed that the fingerprints of different commercial samples of Panax species were variant in their holistic chromatograms and some specific constituents. The method is reliable, reproducible and simple, and can be used as an analytical method for the routine material discrimination of different commercial samples of Panax species. | |||
TO cite this article:Feng Zeng,Wang Xiaoming,Yang Min, et al. Fingerprint analysis of different Panax herbal species by HPLC-UV method[OL].[15 December 2007] http://en.paper.edu.cn/en_releasepaper/content/16989 |
3. Induction of Apoptosis and G2/M Cell Cycle Arrest by Oridonin in Human Gastric Cancer BGC-823 Cells | |||
Jian Han,Ye Min,Qiao Xue,Wu Wanying,Qu Guiqin,Guo Dean | |||
Traditional Chinese Medicine and Pharmacology 14 December 2007 | |||
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Abstract:The in vitro apoptosis-induction effects of oridonin on gastric tumor cells BGC-823 and its effects on cell cycle, mitochondrial membrane potential and intracellular Ca2+ were investigated to shed light on the mode of its anticancer action. The results showed that oridonin inhibited BGC-823 cells growth with IC50 of 22.21 μM. It induced apoptosis in a dose-dependent manner. In addition, it could decrease mitochondria membrane potential, increase intracellular Ca2+, and activate pro-caspase 3. BGC-823 cells were arrested in G2/M cell cycle phase with lower expression of cyclin A protein. The up-regulation of p53 was observed before apoptosis occurred and cell cycle arrest. It suggested that oridonin inhibits the proliferation of BGC-823 cells through G2/M cell cycle arrest and apoptosis induction, which is mediated by influx of Ca2+, up-regulation of p53, activation of caspase-3, and down-regulation of cyclin A. | |||
TO cite this article:Jian Han,Ye Min,Qiao Xue, et al. Induction of Apoptosis and G2/M Cell Cycle Arrest by Oridonin in Human Gastric Cancer BGC-823 Cells[OL].[14 December 2007] http://en.paper.edu.cn/en_releasepaper/content/16926 |
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