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In vitro and in vivo stabilities of doxorubicin aggregates with various salts inside liposomes
Zhang,Lei 1 *,Pan,Hong 1,Liu,Min 2
1.Department of Pharmaceutics, School of Pharmacy, Fudan University
2.Department of Pharmaceutics- School of Pharmacy- Fudan University
*Correspondence author
#Submitted by
Subject:
Funding: 国家自然科学基金,教育部博士点基金(No.30271550,20030246050)
Opened online: 5 January 2005
Accepted by: none
Citation: Zhang,Lei,Pan,Hong,Liu,Min.In vitro and in vivo stabilities of doxorubicin aggregates with various salts inside liposomes[OL]. [ 5 January 2005] http://en.paper.edu.cn/en_releasepaper/content/1419
 
 
iposomes containing different doxorubicin (DOX)-salt aggregates were prepared and the influence of aggregates on the stability of liposomal DOX in vitro and in vivo was investigated. Liposomes were prepared by the film method and hydrated with various buffer, such as, glycine buffer, citric buffer or ammonium sulfate solution. Then DOX was loaded into the liposomes via transmembrane gradient method. Characterizations of liposome were studied and DOX loading efficiency was determined spectrophotometrically. The binding constants (K) of the DOX-salt aggregates were calculated. In vitro leakage of doxorubicin from different aggregates inside liposomes was studied. When liposomal DOX was administered into rats at a dose of 5 mg/kg intravenously, the concentrations of DOX in blood were measured at different time after injection. Results showed the order of the K value of the aggregates was DOX-sulfate aggregates > DOX-citric aggregates > DOX-glycine aggregates. Transmission electron photom
Keywords:Doxorubicin liposome aggregate stability
 
 
 

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