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| To characterize the E2 profiles after oocyte pick-up (OPU) and assess the predictive value of serum E2 in early diagnosis of pregnancy following IVF-ET, in this study sixty-two patients (75 cycles involved) undergoing IVF-ET cycles whose infertility was attributed to tuble factors or male factors were enrolled. Serum E2 was detected on alternate day after OPU with micro-particle enzyme immunoassay. It was found that the level of serum E2 declined progressively after OPU in both pregnant and non-pregnant cycles and showed no significant difference on day 2, 4, 6, 8 days after OPU. In pregnant cycles following IVF-ET, serum E2 reached nadir on day 10 and then increased gradually. The differences of serum E2 level in pregnant and non-pregnant cycles were detectable from day 10 after OPU (816.4±537.6.vs 189.5±69.3 pg/ml) (P<0.05). In non-pregnant cycles, day 10 E2 in was significantly lower than that of day 8(189.5±69.3 vs 989.2±581.5 pg/ml) (P<0.05). We concluded that assessing E2 concentration on day 8 and 10 consecutively after OPU may have predictive value in diagnosing early pregnancy. When prominent drop appears, it’s very likely to see implantation failure.
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| Keywords:Estradiol; IVF–embryo transfer; pregnancy |
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