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PDX-1 expression and significance in pancreatic cancer
Liu Tao,Gou Shan-miao,Wang Chun-you *,Wu He-shui,Xiong Jiong-xin,Zhou Feng
Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
*Correspondence author
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Funding: 教育部博士点基金,国家自然科学基金(No.20050487077,30571817)
Opened online: 7 April 2009
Accepted by: none
Citation: Liu Tao,Gou Shan-miao,Wang Chun-you.PDX-1 expression and significance in pancreatic cancer[OL]. [ 7 April 2009] http://en.paper.edu.cn/en_releasepaper/content/31146
 
 
AIM: To study the correlations of PDX-1 with pancreatic cancer characteristics. METHODS: RT-PCR and WB were used to detect PDX-1 mRNA expression in pancreatic cancer tissue and normal pancreatic tissue. Immunohistochemistry was also used to detect PCNA. RESULTS: Immunohistochemistry, WB and RT-PCR showed that 41.1% of pancreatic cancers were positive for PDX-1 expression. Lymph node metastasis (P < 0.01), TNM grading (P < 0.05), pathological grading (P < 0.05) and tumor cell proliferation (P < 0.01) were significantly correlated with PDX-1 expression levels. CONCLUSION: PDX-1-positive cells may be tumor stem cells and PDX-1 may act as alternate surface marker of pancreatic cancer stem cells.
Keywords:Pancreatic neoplasms; Transcription factors; Tumor stem cells; Lymphatic metastasis; Biological markers
 
 
 

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