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Study of IL-12 Cytokine Therapy for OVA-Induced Asthma Model Mice
Xuewei Qu,Fengqi Li #,Zhigang Tian,Haiming Wei *
Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science & Technology of China, Hefei, Anhui 230027, China.
*Correspondence author
#Submitted by
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Funding: 高等学校博士学科点专项科研基金,国家重大专项,863计划,国家自然科学基金,国家自然科学基金(No.20060358022,2009ZX09102-222,2006AA02Z491,#30730084,#30721002)
Opened online:28 January 2010
Accepted by: none
Citation: Xuewei Qu,Fengqi Li,Zhigang Tian.Study of IL-12 Cytokine Therapy for OVA-Induced Asthma Model Mice[OL]. [28 January 2010] http://en.paper.edu.cn/en_releasepaper/content/39596
 
 
Asthma is the disease of allergic hypersensitivity with airway hyperresponsiveness and airway inflammation. Recent studies have shown that IL-12 has a good role in the treatment of asthma, but the mechanisms are not clearly. Therefore, we construct the OVA-induced mouse asthma to studying the mechanisms of IL-12 treatment. Here we demonstrate that IL-12 treatment ameliorated the pathology of OVA-induced asthma. The roles of IL-12 were to inhibit the increase of NKT cells and promote the increase of NK cells. Furthermore, IL-12 treatment promoted the activation of NK cells and enhanced the expression of IFN-γ in lung NK cells. Our results provide the mechanisms of IL-12 cytokine therapy for OVA-induced asthma model mice.
Keywords:OVA;asthma;interlukin-12;natural killer cells
 
 
 

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