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PGC-1 coactivators in the control of energy metabolism
Liu Chang 1 *,Lin Jiandie 2
1.Jiangsu Key Laboratory for Molecular and Medical Biotechnology, Nanjing Normal University
2.Life Sciences Institute, University of Michigan, Ann Arbor 48109, USA
*Correspondence author
#Submitted by
Subject:
Funding: grants from the Chinese National Science Foundation (No.30870928),Research Fund for the Doctoral Program of Higher Education of China)
Opened online: 3 January 2011
Accepted by: none
Citation: Liu Chang,Lin Jiandie.PGC-1 coactivators in the control of energy metabolism[OL]. [ 3 January 2011] http://en.paper.edu.cn/en_releasepaper/content/4401160
 
 
Chronic disruption of energy balance, where energy intake exceeds expenditure, is a major risk factor for the development of metabolic syndrome. The latter is characterized by a constellation of symptoms including obesity, dyslipidemia, insulin resistance, hypertension, and non-alcoholic fatty liver disease (NAFLD). Altered expression of genes involved in glucose and lipid metabolism as well as mitochondrial oxidative phosphorylation (OXPHOS) has been implicated in the pathogenesis of these disorders. The peroxisome proliferator-activated receptor (PPAR)-γ coactivator-1 (PGC-1) family of transcriptional coactivators is emerging as a hub linking nutritional and hormonal signals and energy metabolism. PGC-1α and PGC-1βare highly responsive to a variety of environmental cues and coordinates metabolic gene transcription through interaction with transcription factors and chromatin-remodeling proteins. PGC-1α has been implicated in the pathogenic conditions such as obesity, type 2 diabetes, neurodegeneration, and cardiomyopathy, whereas PGC-1βplays an important role in plasma lipoprotein homeostasis and serves as a hepatic target for niacin, a potent hypotriglyceridemic drug. Here, we review recent advances in the identification of physiological and pathophysiological contexts involving PGC-1 coactivators, and also discuss their implications for therapeutic development.
Keywords:transcriptional coactivator;metabolic syndrome;PGC-1;mitochondrial;energy metabolism
 
 
 

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