Effects of Down-regulated miR-143 on Human Bronchial Epithelial Cells Exposed to Benzo[a]pyrene

Wang Xikai; Zhang Yanqiu; Pu Yuepu; Yin Lihong; Liang Geyu

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Effects of Down-regulated miR-143 on Human Bronchial Epithelial Cells Exposed to Benzo[a]pyrene

Wang Xikai,Zhang Yanqiu,Pu Yuepu,Yin Lihong,Liang Geyu *

Key Laboratory of Environmental Medicine and Engineering, Ministry of Education; School of Public Health, Southeast University

*Correspondence author

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Funding: National Natural Science Foundation of China （No.No.30700650）, Research Fund for the Doctoral Program of Higher Education of China（No.No. 20070286070）, Natural Science Foundation of Jiangsu Province（No.No.BK2007565）

Opened online:14 January 2011

Accepted by: none

Citation: Wang Xikai,Zhang Yanqiu,Pu Yuepu.Effects of Down-regulated miR-143 on Human Bronchial Epithelial Cells Exposed to Benzo[a]pyrene[OL]. [14 January 2011] http://en.paper.edu.cn/en_releasepaper/content/4402435

MicroRNAs(miRNAs) are small non-coding RNAs, which have the association with the occurrence or the development of the cancer. In this study, we investigated the effect of the down-regulated miR-143 on human bronchial epithelial cells (16-HBE) exposed to Benzo[a]pyrene [B(a)P]. Anti-miR-143 was transfected into cells to down-regulate the expression of miR-143. Cell proliferation, apoptosis and cycle of transfected cells were detected by methyl thiazolyl tetrazolium (MTT) assay and flow cytometry after 24 h exposed of B(a)P, respectively. Our results confirmed that B(a)P had significant toxic effect on the cell proliferation, raised the apoptosis rate and blocked more cells at the S period in cell cycle (P<0.05). However, there was no significant difference between transfected group and non-transfected group after cells exposed to B(a)P (P>0.05). The results suggested that down-regulated miR-143 has no significant influence on cellar bio-effects induced by B(a)P under the present experimental conditions.

Keywords:miR-143; B(a)P; Human Bronchial Epithelial Cells; Cell Proliferation; Cell Apoptosis; Cell Cycle

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