Photo-responsive organic-inorganic hybrid sol-gel material for Ibuprofen

TANG Qian; GONG Chengbin; FU Xiangkai; LIN Hanhua

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Photo-responsive organic-inorganic hybrid sol-gel material for Ibuprofen

TANG Qian 1,GONG Chengbin 1 * #,FU Xiangkai 1,LIN Hanhua 2

1.The College of Chemistry and Chemical Engineering, Southwest University

2.The department of Biology &Chemistry, City University HongKong

*Correspondence author

#Submitted by

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Funding: The work described in this paper was supported by Specialized Research Fund for the Doctoral Program of Higher Education （No.20090182120010）

Opened online:17 May 2011

Accepted by: none

Citation: TANG Qian,GONG Chengbin,FU Xiangkai.Photo-responsive organic-inorganic hybrid sol-gel material for Ibuprofen[OL]. [17 May 2011] http://en.paper.edu.cn/en_releasepaper/content/4426723

In this paper, a photo-responsive molecularly imprinted organic-inorganic hybrid sol-gel material was prepared by covalent imprinting of the template (ibuprofen) - functional monomer (4-hydroxyl-4′-[(Triisopropoxysilyl)propyloxy] azobenzene) for the specific binding of ibuprofen. After imprinting, ibuprofen was removed via hydrolysis in acid. The new molecularly imprinted organic-inorganic hybrid sol-gel material was found to behavior similarly to the organic polymer based photo-responsive molecularly imprinted polymer (MIP). The favorable binding strength of the imprinted receptor sites in the MIP for ibuprofen was found to be 2.28 x 103 M-1. Density of receptor sites in the MIP material was 4.0 ?mol/g-MIP. The release and uptake of ibuprofen from THF solution by the material could be reversibly photo-regulated upon alternate irradiation at 365 and 440 nm, respectively.

Keywords:Photo-responsive organic-inorganic hybrid materials; Ibuprofen; Azobenzene; Sol-gel process

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