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Antidepressant effect of Cynanchum wallichii in Mice
YANG Qiong-xiong 1 * #,HUANG Xiao-yan 2
1.School of Chemistry and Material Science, Guizhou Normal University
2.School of Life Sciences, Guizhou Normal University, Guiyang 550001
*Correspondence author
#Submitted by
Subject:
Funding: NSFC (No.No. 30760032), Foudantion of Science and Technology Department of Guizhou Province(No.[2007]No.2145), Sepcial Foundation for Traditional Chinese Medicine Modernization of Guizhou Province(No.[2008] No.5022), Governor Foundation of Guizhou Province (No.[2007] No.34)
Opened online: 4 August 2011
Accepted by: none
Citation: YANG Qiong-xiong,HUANG Xiao-yan.Antidepressant effect of Cynanchum wallichii in Mice[OL]. [ 4 August 2011] http://en.paper.edu.cn/en_releasepaper/content/4436987
 
 
In this paper, the antidepressant activity of the total glycosides from C. wallichii (TGCW) is investigated for the first time. The tail suspension test (TST), forced swimming test (FST) and open field test (OPT) in mice were used to evaluated the antidepressant effect of TGCW, and experiment of antagonism of reserpine-induced ptosis and hypothermia in mice was conducted to evaluate whether the central monoaminergic neurotransmitter system was involved in the mechanism of the antidepressant activity. The results showed that reduction of the immobility duration in TST and FST in mice showed the obvious dose-response relation for TGCW. With a dose of 80 mg/kg, reduction degree was 47.4% (p<0.01) in TST and 48.2% (p<0.01) in FST, corresponding to 64.1% (p<0.01) and 62.3% (p<0.01) for the positive control chlorimipramine (20 mg/kg, i.g.). The number of crossing and rearing mice in treating groups was not significantly different from that in the vehicle control group, and only at dose of 80mg/kg significantly antagonized reserpine-induced ptosis and hypothermia in mice. These findings demonstrate that TGCW have apparent antidepressant activity, and the mechanism via central monoaminergic neurotransmitter system for the antidepressant activity of TGCW may be involved.
Keywords:antidepressant effect; Cynanchum wallichii; C21 steroidal glycosides
 
 
 

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