Preparation of Silymarin Nanosuspension by Microemulsion Dilution

Zeng Hui; Huihua Li

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Preparation of Silymarin Nanosuspension by Microemulsion Dilution

Zeng Hui 1 * #,Huihua Li 2

1.School of Chemistry and Chemical Engineering, Sun Yat-sen University

2.School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, P.R.China

*Correspondence author

#Submitted by

Subject:

Funding: Foundation for the junior teachers in Sun Yat-Sen University（No.NO 2008310001131467）, Foundation for Distinguished Young Talents in Higher Education of Guangdong, China（No.NO 2010310004201573）

Opened online:21 September 2011

Accepted by: none

Citation: Zeng Hui ,Huihua Li.Preparation of Silymarin Nanosuspension by Microemulsion Dilution[OL]. [21 September 2011] http://en.paper.edu.cn/en_releasepaper/content/4442628

Nanosuspensions of silymarin with size distribution 31-326nm were prepared though microemulsion dilution. Dynamic light scattering showed that the size of nanoparticles of silymarin changed by increasing the volume of diluted water. Transmission electron microscopy confirmed that these colloidal nanoparticles have irregular shape. This research shows that silymarin nanoparticles can be formed from microemulsion with suitable oil and surfactant.

Keywords:silymarin; microemulsion; nanoparticle; nanosuspension; diffusion

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