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FOXP3 gene polymorphism is associated with Chronic Hepatitis B in China
CHEN Yanhui 1,ZHANG Henghui 1 #,WANG Yan 2,LIAO Weijia 2,QIN Liling 2,XIE Xingwang 1,FEI Ran 1,WANG Xueyan 1,MEI Minghui 2,WEI Lai 1,CHEN Hongsong 1 *
1.Peking University People’s Hospital, Peking University Hepatology Institute, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Beijing 100044
2.Affiliated Hospital of Guilin Medical University, Guilin 541004
*Correspondence author
#Submitted by
Funding: National Natural Science Foundation of China (No.No. 91029741 and No. 81001072), the Specialized Research Fund for the Doctoral Program of Higher Education (No.200800011091), National Key Sci-Tech Special Project of China (No.no. 2008ZX10002-019 and No. 2008ZX10002-008)CHEN Yan-hui and Zhang Heng-hui are contributed equally to this pape)
Opened online: 1 February 2012
Accepted by: none
Citation: CHEN Yanhui,ZHANG Henghui,WANG Yan.FOXP3 gene polymorphism is associated with Chronic Hepatitis B in China[OL]. [ 1 February 2012] http://en.paper.edu.cn/en_releasepaper/content/4463056
Background and aims: The forkhead transcription factor Foxp3 is a key molecular which can mediate regulatory T cells immune-related inhibitory functions. Increased levels of FOXP3-positive Tregs in peripheral blood and focus of infection have been proved to be associated with a less favorable prognosis in various inflammatory diseases. It is of great interest to investigate the correlation between single nucleotide polymorphisms (SNPs) of FOXP3 gene and the susceptibility of Chronic Hepatitis B (CHB). Methods: Two SNPs rs2280883 and rs3761549 of FOXP3 gene in 344 patients with CHB and 372 matched controls were analyzed by Matrix-Assisted Laser Desorption/ Ionization Time of Flight Mass Spectrometry (MALDI-TOF). Results: At rs2280883 and rs3761549, there were no significant differences in the distribution of C and T alleles between CHB donors and healthy donors. Compared with healthy controls, patients with CHB had higher frequencies of TT genotype (74.1%) at rs2280883 or CC genotype (74.6%) at rs3761549 of FOXP3 gene. Patients who carried rs2280883 TT genotype (OR 1.1268 [95%CI 0.8097-1.5680], P<0.01) or rs3761549 CC genotype (OR 1.6291 [95%CI 1.1774-2.2541], P<0.00001) had high risk of suffering from CHB. Stratified analysis showed that rs2280883 TT/CT genotype was significantly associated with high incidence of HBeAg (P<0.01), and rs3761549 TT/CT genotype was also significantly associated with high incidence of HBeAg (P<0.01). Conclusions These results suggested that FOXP3 gene polymorphisms at rs2280883 and rs3761549 might be associated with the increased susceptibility to CHB.
Keywords:Hepatitis B, Chronic; Gene polymorphism; FOXP3

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