Tim-2 Up-regualtion and Galectin-9-Tim-3 Pathway Activation in Th2-Biased

QI Yao; SONG Xiaorong; SHEN Jilong; XU Yuanhong; SHEN Qian; LUO Qingli; ZHONG Zhengrong; WANG Wei; CHU Deyong; SONG Wenjian

Chinese︱Feedback︱Save this page

• Elaborating Academic Views 　　　　 • Exchanging Innovative Ideas
• Protecting Intellectual Properties 　　• Fast Sharing Science Papers

Sponsored by the Center for Science and Technology Development of the Ministry of Education
Supervised by Ministry of Education of the People's Republic of China

Home > Papers

Tim-2 Up-regualtion and Galectin-9-Tim-3 Pathway Activation in Th2-Biased

QI Yao 1,SONG Xiaorong 1,SHEN Jilong 2 *,XU Yuanhong 1,SHEN Qian 1,LUO Qingli 3 #,ZHONG Zhengrong 1,WANG Wei 4,CHU Deyong 1,SONG Wenjian 1

1.Provincial Key Laboratories of Microbiology & Parasitology, and Zoonoses Anhui, Anhui Medical University, Hefei, Anhui, China, 230032

2. Institute of Anhui Cardiovascular Research, Anhui Provincial Hospital, Hefei, Anhui, China, 230032

3. Clinical Laboratory, The First Hospital of Anhui Medical University, Hefei, Anhui, China, 230032

4. Department of Immunology, Anhui Medical University, Hefei, Anhui, China, 230032

*Correspondence author

#Submitted by

Subject:

Funding: Specialized Research Fund for the Doctoral Program of Higher Education （No.No. 200803660003）, National Natural Science Foundation of China （No.No. 8107137）, Provincial Natural Science Foundation of Anhui （No.No.090413089）

Opened online:15 March 2012

Accepted by: none

Citation: QI Yao,SONG Xiaorong,SHEN Jilong.Tim-2 Up-regualtion and Galectin-9-Tim-3 Pathway Activation in Th2-Biased[OL]. [15 March 2012] http://en.paper.edu.cn/en_releasepaper/content/4469018

T cell immunoglobulin domain and mucin domain (Tim) family, a new gene that expresses on the surface of T cells, plays a critical role in regulation of T cells response. Previous data have shown that Tim-3 expressed on Th1 cells promotes itself apoptosis. Tim-2 is preferentially up-regulated during Th2 differentiation and functions as a potent costimulatory molecule for T-cell immunity. The present study aims to learn whether Tims proteins are responsible for Th2-biased response evoked by Schistosoma japonicum infection. The expressions of Tim-2 and Tim-3 in spleen lymphocytes from S. japonicum-infected mice were examined, and the possible role of galectin-9-Tim-3 pathway in Th2-biased response triggered by schistosome infection was discussed. Our results showed that schistosome infection could up-regulate Tim-2 which coincided with elevated IL-4 gene expression. Administration of galectin-9 significantly induced apoptosis of native spleen lymphocytes with down-regulation IFN-γexpression in vitro. Additionally, Tim-3-Fc fusion protein notably enhanced Th1 cells and decreased Th2 cells in vitro. Thus, we concluded that pro-apoptotic effects on Th1 population through galectin-9-Tim-3 pathway and the up-regulation of Tim-2 on Th2 cells might be critical to Th2-biased response of host with schistosomiasis japonica.

Keywords:T cell immunoglobulin domain and mucin domain; galectin-9; apoptosis; Th2-biased response; schistosomiasis.

For this paper

● PDF (0B)
● Revision 0 　　
● Print this paper
● Recommend this paper to a friend
● Add to my favorite list

Saved Papers

Please enter a name for this paper to be shown in your personalized Saved Papers list

Tags

Add yours

Related Papers

Statistics

PDF Downloaded	223
Bookmarked	0
Recommend	5
Comments	Array

Submit your papers

Alert Name:
Alerting to:
Authentication email will be sent to your email address in 24 hours
Frequency:
Email Message Format:	Plain text Graphical(HTML)

Complete the form below and we will recommend the selected titles to your friends on your behalf. * Indicates a required field.
Your name*:
Your email address*:
Recipient's name*:
Recipient's email address*:
(multiple recipient's names and email addresses should be separated with semicolons)
Your comments:	I thought you would find the page(s) useful.

Your name:
Your email address:
Recipient's name:
Recipient's email address:
(multiple recipient's names and email addresses should be separated with semicolons)
Your comments:	I thought you would find this page useful.

Disclaimer: This message was sent to your friend using the "Send it to a friend" facility on the Sciencepaper Online’ WWW site, http://www.paper.edu.cn/en. The Sciencepaper Online is not responsible for the content of this email, and anything said in this email does not necessarily reflect the Sciencepaper Online's views.

	Check out RSS, or use RSS reader to subscribe this item

Saved Papers