Sexual dimorphism of steroidogenesis regulated by GnIH in the Goldfish, Carassius auratus

QI Xin; ZHOU Wenyi; LU Danqi; LI Shuisheng; LIU Xiaochun; ZHANG Yong; LIN Haoran

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Sexual dimorphism of steroidogenesis regulated by GnIH in the Goldfish, Carassius auratus

QI Xin #,ZHOU Wenyi,LU Danqi,LI Shuisheng,LIU Xiaochun,ZHANG Yong *,LIN Haoran

State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals, Sun yat-sen University,510275

*Correspondence author

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Subject:

Funding: National Basic Research Program （No.973 program, No. 2010CB126302), the National Science Foundation of China）

Opened online:28 December 2012

Accepted by: none

Citation: QI Xin,ZHOU Wenyi,LU Danqi.Sexual dimorphism of steroidogenesis regulated by GnIH in the Goldfish, Carassius auratus[OL]. [28 December 2012] http://en.paper.edu.cn/en_releasepaper/content/4504673

Gonadotrophin-inhibitory hormone (GnIH) has pronounced inhibitory effects on reproduction in a number of species. GnIH suppresses gonadotropin synthesis/release at the hypothalamic and pituitary levels; however, increasing evidences suggested a putative function on the gonad. In this study, we have demonstrated the localization of receptors for GnIH in ovary and testis of goldfish. In situ hybridization showed that goldfish GnIHRs were localized only in the oocytes before cortical alveolus stage, and were localized in the interstitial tissue of testis. Implantation of goldfish GnIH peptides reduced the serum estradiol level in the female goldfish, but enhanced serum testosterone level in the male goldfish. Besides, injection of goldfish GnIH peptides increased the expression of StAR and 3bHSD mRNA and decreased the expression of CYP19 mRNA significantly in testis, while showed no effect on these genes in ovary. In addition, in vitro results showed that goldfish GnIH peptides not only increased the expression of StAR, 3bHSD and decreased CYP19 mRNA, but also increased the expression of FSHR and LHR mRNA in testis cells, but showed no effect on the expression of detected genes in ovary cells. Thus, we believe that GnIH could contribute to the sexual dimorphism of steroidogenesis in goldfish.

Keywords:GnIHR; localization; steroidogenesis; goldfish

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