Association Between Genetic Variants in pre-miRNA and Colorectal Cancer Risk in a Chinese Population

Lv Meili; Dong Wei; Wei Yonggang; Li Lijuan; Zhang Lushun; Shu Xiaowei; Wang Li; Gao Linbo*; Zhang Lin*

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Association Between Genetic Variants in pre-miRNA and Colorectal Cancer Risk in a Chinese Population

Lv Meili 1,Dong Wei 2,Wei Yonggang 3,Li Lijuan 4,Zhang Lushun 5,Shu Xiaowei 5,Wang Li 5,Gao Linbo* 6,Zhang Lin* 7 *

1.Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041

2. Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, P.R.China

3.Department of Liver and Vascular Surgery, the West China Hospital of Sichuan University, Chengdu, Sichuan 610041, P.R. China

4. Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, P.R.China

5.Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, P.R.China

6. Laboratory of Molecular Translational Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R.China , Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Chengdu, Sichuan 610041, P.R.China,

7. Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, P.R.China , Laboratory of Molecular Translational Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R.China , Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Chengdu, Sichuan 610041&

*Correspondence author

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Funding: New Teachers‘Fund for Doctor Stations, Ministry of Education of China（No.grant no : 20090181120021 and grant no : 20090181120111）, Natural Science Foundation of China （No.grant no:81000515）

Opened online: 4 February 2013

Accepted by: none

Citation: Lv Meili,Dong Wei,Wei Yonggang.Association Between Genetic Variants in pre-miRNA and Colorectal Cancer Risk in a Chinese Population[OL]. [ 4 February 2013] http://en.paper.edu.cn/en_releasepaper/content/4517990

Background: Single nucleotide polymorphisms (SNPs) in pre-miRNAs may alter microRNA expression levels or processing and then contribute to the susceptibility of cancer development. We hypothesized that SNPs in pre-miRNAs may be association associated with the risk of colorectal cancer (CRC). Methods: We used genotyped four common polymorphisms (i.e., rs11614913, rs3746444, rs2910164, and rs2292832) in pre-miRNAs of 353 CRC patients and 540 healthy controls to investigate the association between the SNPs and the risk of CRC using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) genotyped four common polymorphisms(rs11614913, rs3746444, rs2292832 and rs2910164) in pre-miRNAs of 353 CRC patients and 540 healthy controls to investigate the association between them and the risk of CRC assay..Results: The rs11614913 CT, TT genotypes and T allele were associated with an increased risk of CRC compared with the CC genotype and C allele (CT vs. CC: OR＝7.34, 95% CI, 3.76-14.34; TT vs. CC: OR＝13.66, 95% CI, 6.76-27.6; T vs. C: OR＝1.99, 95% CI, 1.63-2.42, respectively). Interestingly, using the rs2910164 GG genotype as a reference, the rs2910164 GC genotype was associated with an increased risk of CRC (OR＝1.49, 95% CI, 1.02-2.18), whereas the rs2910164 CC genotype was associated with a decreased risk of CRC (OR＝0.58, 95% CI, 0.37-0.93). When compared with the rs2910164G allele, rs2910164 C allele was associated with a reduced risk of CRC (OR＝0.80, 95% CI, 0.66-0.97, P=0.02). significantly increased CRC risk were found to be associated with CT genotype (OR＝0.136, 95% CI: 0.070-0.266) and TT genotype (OR＝0.073, 95% CI: 0.036-0.148) vs. CC genotype of rs11614913, CT (OR＝0.166, 95% CI: 0.037-0.735,) and TT genotype (OR＝0.167, 95% CI: 0.038-0.729) vs. CC genotype of rs3746444, and GC genotype (OR＝0.670, 95% CI: 0.460-0.977) vs. GG genotype of rs2910164. Unfortunately, there were no statistically significant differences between cases and controls in genotype of rs2292832. When compared with the alleles, significantly increased CRC risk were found to be associated with T allele (OR＝0. 530, 95% CI: 0.413-0.613) vs. C allele in rs11614913. There were no statistically significant differences between cases and controls in alleles of rs3746444, rs2292832 and rs2910164.Conculsion: These findings suggest that rs11614913 and rs2910164 polymorphisms may be associated with the etiology of CRC.

Keywords:colorectal Colorectal cancer; pre-miRNA; Single nucleotide polymorphism

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