Regulation of PTHrP on MMP13 in Sika Deer Antler Chondrocytes

WANG Shoutang; GUO Bin; LI Dangdang; TIAN Xuechao; YUE Zhanpeng

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Regulation of PTHrP on MMP13 in Sika Deer Antler Chondrocytes

WANG Shoutang,GUO Bin #,LI Dangdang,TIAN Xuechao,YUE Zhanpeng *

College of Veterinary Medicine, Jilin University, Changchun 130062

*Correspondence author

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Funding: Research Fund for the Doctoral Program of Higher Education of China （No.No. 20100061110078）, National Natural Science Foundation of China（No.No. 31072099 and 31101778）

Opened online:25 March 2013

Accepted by: none

Citation: WANG Shoutang,GUO Bin,LI Dangdang.Regulation of PTHrP on MMP13 in Sika Deer Antler Chondrocytes[OL]. [25 March 2013] http://en.paper.edu.cn/en_releasepaper/content/4528943

Deer antlers are the only mammalian appendages to display annual cycle of full regeneration. However, little is known about the molecular mechanisms of antler regeneration. Our previous study has demonstrated that parathyroid hormone-related peptide (PTHrP) can promote proliferation of antler chondrocytes and inhibit its differentiation. But the mechanism underlying such regulation is not fully understood. The present study aimed to determine the role of PTHrP on the mRNA expression of matrix metalloproteinase-13 (MMP13) in the antler chondrocytes. The possible pathways that transduce PTHrP effects were also investigated in the cells. The in situ hybridization results showed that MMP13 were mainly localized in the dermal fibroblasts, perichondrium and cartilage in the sika deer antler, of which MMP13 were highly expressed in the antler chondrocytes. Exogenous PTHrP could inhibit the expressions of MMP13 in the antler chondrocytes. The inhibitory effect of PTHrP on MMP13 was eliminated by P38MAPK inhibitor SB203850 and PKC inhibitor GF109203X. These results suggest that PTHrP can inhibit MMP13 expression by p38MAPK and PKC signaling pathways in the antler chondrocytes, thus PTHrP is involved in the control of antler chondrocytes maturation and cartilage matrix degradation.

Keywords:basic veterinary medicine; PTHrP; MMP13; chondrocyte; sika deer antler

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