Home > Papers

 
 
The role of Fascin-1 and E-cadherin expression in laryngeal squamous cell carcinoma
ZOU Jian 1 * #,YANG Hui 2,CHEN Fei 2,LI Wen 2,WANG Lihong 2,LIU Shixi 2
1.Department of Otolaryngology, West China Hospital of Sichuan University, ChengDu 610041
2.Department of Otolaryngology, West China Hospital of Sichuan University
*Correspondence author
#Submitted by
Subject:
Funding: Specialized Research Fund for the Doctoral Program of Higher Education.(No.No.20090181120101)
Opened online:20 March 2013
Accepted by: none
Citation: ZOU Jian,YANG Hui,CHEN Fei.The role of Fascin-1 and E-cadherin expression in laryngeal squamous cell carcinoma[OL]. [20 March 2013] http://en.paper.edu.cn/en_releasepaper/content/4529483
 
 
Fascin-1 and E-cadherin which are related with cell motility and cell adhesiveness are important factors in the progression and metastasis of cancers. The objective of this study was to explore the association of Fascin-1 and E-cadherin expression level with clinical characteristics and prognosis of patients with laryngeal squamous cell carcinoma. In our study, tumor tissue samples from 150 patients with laryngeal squamous cell carcinoma were determined for Fascin-1 and E-cadherin expression by immunohistochemistry. The statistical analysis was performed to evaluate the association of Fascin-1 and E-cadherin expression with clinical characteristics and patient's prognosis. As a result, Fascin-1 expression was an independent predictive factors for recurrence in patients with laryngeal squamous cell carcinoma (P=0.021) and independently related to disease-free survival(P=0.010). Although E-cadherin expression status was not the independent predictive factors for recurrence (P=0.055) or disease-free survival (P=0.063), the subgroup with Fascin-1 high expression/E-cadherin low expression has the poorest prognosis (P=0.000) using subgroup analysis. In conclusion, Fascin-1 expression could be a potential prognostic predictor for patients with laryngeal squamous cell carcinoma. Simultaneous analysis of Fascin-1 and E-cadherin expression could be more effective to evaluate the prognosis of patients with laryngeal squamous cell carcinoma.
Keywords:Fascin-1; E-cadherin; Laryngeal squamous cell carcinoma; Immunohistochemistry; Recurrence
 
 
 

For this paper

  • PDF (0B)
  • ● Revision 0   
  • ● Print this paper
  • ● Recommend this paper to a friend
  • ● Add to my favorite list

    Saved Papers

    Please enter a name for this paper to be shown in your personalized Saved Papers list

Tags

Add yours

Related Papers

Statistics

PDF Downloaded 245
Bookmarked 0
Recommend 5
Comments Array
Submit your papers