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Immunomodulatory effects of Lactobacillus casei Zhang in a murine model of peanut allergy
Mengsha Hu 1,Qiuxiang Zhang 2,Xiaoming Liu 2,Gang Wang 2,Hao Zhang 2,Wei Chen 2 *
1.School of Food Science and Technology, Jiangnan University, JiangSu WuXi 214122
2.School of Food Science and Technology, Jiangnan University, Wuxi 214122
*Correspondence author
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Subject:
Funding: the National High Technology Research and Development Program of China(No.863 Program No. 2011AA100901, 2011AA100902), the National Basic Research Program of China(No.973 Program No. 2012CB720802), Fundamental Research Funds for the Central Universities(No.JUSRP111A31), the Key projects in the national science & technology pillar program during the twelfth five-year plan period(No.No. 2012BAD12B08, 2012BAD28B07), the National Science Fund of Distinguished Young Scholars(No.No. 31125021), the National Science and Technology Pillar Program (No.No.2010C0070311), the National Natural Science Foundation of China (No.No. 31200691), the Key program of National Natural Science Foundation of China(No.No. 20836003)
Opened online:21 March 2013
Accepted by: none
Citation: Mengsha Hu,Qiuxiang Zhang,Xiaoming Liu.Immunomodulatory effects of Lactobacillus casei Zhang in a murine model of peanut allergy[OL]. [21 March 2013] http://en.paper.edu.cn/en_releasepaper/content/4530123
 
 
Probiotics can modulate systemic and mucosal immune systems, as well as induce immune tolerance in allergic diseases. The aim of this study was to evaluate the immunomodulatory potential of Lactobacillus casei Zhang on prophylactic and therapeutic effects in a mouse model of peanut allergy. Intragastrical administration with L. casei Zhang, prior or after allergic sensitization, led to increased levels of serum allergen-specific IgG2a and mucosal IgA antibodies. Additionally, systemic anaphylactic symptoms and Th2 responses (IgE antibody, histamine release and IL-4 production) were attenuated. L. casei Zhang had less influence on the serum IgG1 antibody and other cytokines (IL-10, IL-12 and IFN-γ). Successful immunomodulation by pre and post-treatment were further demonstrated by an augment of the IFN-γ/IL-4 ratio in vitro and enrichment of CD4+ Foxp3+ Tregs in spleen and mesenteric lymph nodes. These results suggested that L.casei Zhang may play a role in preventing and treating peanut allergy.
Keywords:Food Science; Lactobacillus casei Zhang; peanut allergy; Th1/Th2 balance; regulatory T cells
 
 
 

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