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Transcriptome analysis of murine thymic epithelial cells reveals age-associated changes in microRNA expression
Guo Zhibin 1,Chi Feng 2,Song Yan 2,Wei Tianli 2,Zhu Xike 2 *
1.Research Center, The Shenging Hospital of China Medical University, ShenYang 110004
2.Research Center, The Shengjing Hospital of China Medical University
*Correspondence author
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Funding: This work was supported by National Natural Scientific Foundation of China (No.grant number: 30872715), by The Special Research Fund for Doctoral Program of Education Department of China(No.grant number: 20112104110011), by Free Research Program Fund of The Shengjing Hospital(No.grant number: 200805)
Opened online:27 August 2013
Accepted by: none
Citation: Guo Zhibin,Chi Feng,Song Yan.Transcriptome analysis of murine thymic epithelial cells reveals age-associated changes in microRNA expression[OL]. [27 August 2013] http://en.paper.edu.cn/en_releasepaper/content/4556213
 
 
Age-related thymic involution is accompanied by a decrease in thymopoiesis and thus deficiency in T-cell-mediated immunity in the elderly. Many events involved in thymic involution have been discovered; however, it is unclear if they are causes or consequences of thymic involution. These events include the degeneration of T-cell progenitors as well as the deterioration of the thymic stroma, which is a characteristic of thymic epithelial cell loss due to increased apoptosis and decreased cell proliferation. MicroRNA (miRNA) is believed to play important roles in regulating cell death and proliferation in the aging network. The aim of this study is to profile the miRNA expression in thymic epithelial cells and delineate the change in the expression level along with thymic aging. By comparing the expression levels of various miRNAs in thymic epithelial cells and their changes in different age groups, this study provides first-hand information about the changes of miRNA expression in the thymic stroma with aging.
Keywords:Aging; Thymic stroma; Involution; MicroRNA
 
 
 

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