Home > Papers

 
 
Iron status and lipopolysaccharide regulate Ndfip1 by activation of nuclear factor-kappa B
XU Huamin 1 #,CHANG Qing 2,JIA Wenting 3,JIANG Hong 3,SUN Peng 2 #,XIE Junxia 3 *
1.Department of Physiology, Medical College of Qingdao University, ShanDong QingDao 266071
2.The affiliated hospital of Medical College Qingdao University
3.Department of Physiology, Medical College of Qingdao University
*Correspondence author
#Submitted by
Subject:
Funding: Department of Health of Shandong （No.2011QZ006）, Ministry of Education of China（No.20103706120001）, National Program of Basic Research sponsored by the Ministry of Science and Technology of China （No.2011CB504102）, Shandong Provincial Education Department（No.J11LC05）, the National Foundation of Natural Science of China（No.30930036, 81100955）, Department of Science & Technology of Shandong Province （No.BS2010SW009）
Opened online: 6 September 2013
Accepted by: none
Citation: XU Huamin,CHANG Qing,JIA Wenting.Iron status and lipopolysaccharide regulate Ndfip1 by activation of nuclear factor-kappa B[OL]. [ 6 September 2013] http://en.paper.edu.cn/en_releasepaper/content/4557706
 
 
Nedd4 family interacting protein 1 (Ndfip1) is an adaptor protein for the Nedd4 family of ubiquitin ligases that target proteins for degradation. Recent studies confirmed the role of Ndfip1 as a regulator of iron metabolism and pointed out that Ndfip1 was involved in iron homeostasis by regulating the degradation of iron importer divalent metal transporter 1 (DMT1). However, little is known about how Ndfip1 is regulated. The aim of this article was to investigate the regulation of Ndfip1 levels and the possible mechanisms. In this study, we investigated the effect of various stimuli, including iron status and lipopolysaccharide (LPS) on Ndfip1 expression in MES23.5 dopaminergic cell lines. Results showed that Ndfip1 expression in these cells was enhanced by ferrous iron overload, but not ferric iron overload, and decreased after iron deprivation by desferoxamine (DFO). In addition, LPS could significantly increase the expression of Ndfip1. Furthermore, we demonstrated that the regulation of Ndfip1 expression by these various stimuli was achieving by activation of nuclear factor-kappa B. We speculate that iron status and LPS may contribute to the changes of Ndfip1 expression by activation of nuclear factor-kappa B.
Keywords:Ndfip1; iron overload; lipopolysaccharide; desferoxamine
 
 
 

For this paper
  • ● PDF (0B)
  • ● Revision 0 　　
  • ● Print this paper
  • ● Recommend this paper to a friend
  • ● Add to my favorite list

    Saved Papers

    Please enter a name for this paper to be shown in your personalized Saved Papers list

Tags
Add yours

Related Papers
  • Other similar papers

Statistics
PDF Downloaded 192
Bookmarked 0
Recommend 5
Comments Array
Submit your papers